98 research outputs found

    Plan estrat茅gico para Bell Corporation Inc. 2023-2027

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    El presente trabajo desarrolla una propuesta de plan estrat茅gico para la empresa Bell Corporation Inc., la cual se dedica a la fabricaci贸n y la comercializaci贸n de dispositivos m贸viles para las empresas de telecomunicaciones que operan en las regiones de China, Europa y Estados Unidos. Para el desarrollo de la estrategia se revisaron los aspectos que ayuden a Bell Corporation Inc. A incrementar su participaci贸n de mercado y beneficios para sus accionistas. Para esto, se realiz贸 el an谩lisis interno, an谩lisis externo y an谩lisis de mercado, con el fin de estimar correctamente la demanda e identificar el mercado potencial, objetivo y meta para los pr贸ximos 5 a帽os. Se desarrollaron los planes funcionales integrados por el plan de Marketing, el plan de Operaciones, el plan de Recursos Humanos, el plan de Responsabilidad Social y el plan de Finanzas; estos planes describen la estrategia para lograr los objetivos de diferenciaci贸n y rentabilidad en el negocio, sobre la base de la inversi贸n en investigaci贸n y desarrollo acompa帽ado de una configuraci贸n organizacional 鈥渁dhocr谩tica鈥 para el lanzamiento de dispositivos m贸viles para deportistas con tecnolog铆a 5G. Este plan con enfoque en estrategia de diferenciaci贸n permite satisfacer tanto la demanda del mercado y el posicionamiento de Bell Corporation Inc. en el mercado asi谩tico

    La Ant谩rtida en la geopol铆tica ambiental de Estados Unidos

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    En este cap铆tulo se analiza la pol铆tica estadounidense ant谩rtica determinada por sus intereses de seguridad nacional y que explica su actual sistema de gobernanza junto con proyectar un escenarioglobal altamente conflictivo que influir谩 en el derrotero de su situaci贸n geopol铆tica. La generaci贸n de conocimiento sobre este tema tiene un sentido estrat茅gico para pa铆ses del Cono Sur, como Chile yArgentina que, si bien tienen importantes e hist贸ricos intereses en la Ant谩rtida, juegan un papel perif茅rico en la pol铆tica mundial.Fil: Estenssoro Saavedra, Fernando. Universidad de Santiago de Chile; ChileFil: Zuniga, Javier. Universidad de Santiago de Chile; ChileFil: Lorenzo, Cristian A.. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Austral de Investigaciones Cient铆ficas; Argentina. Universidad Nacional de Tierra del Fuego. Instituto de Ciencias Polares, Recursos Naturales y Ambiente; Argentin

    Introduction

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    Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.

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    Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18鈥924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score鈥搈atched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9鈥3.6], 4.0 [95% CI, 3.6鈥4.5], and 5.5 [95% CI, 5.0鈥6.1] events per 100 patient-years in strata 35鈥<50, and 鈮35 mg/dL, respectively). Compared with propensity score鈥搈atched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non鈥揾igh-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non鈥揾igh-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as 鈮35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.gov; Unique identifier: NCT01663402.URL: https://www

    The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

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    International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

    Testing Phylogeographic Hypotheses in Mepraia (Hemiptera: Reduviidae) Suggests a Complex Spatio-Temporal Colonization in the Coastal Atacama Desert

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    Simple Summary Mepraia is a blood-sucking bug endemic to Chile and a vector of the parasite that causes Chagas disease. Different colonization routes have been suggested for this bug; therefore, we tested different colonization routes using DNA sequences and bioinformatics approaches to select the most probable route. Our results suggest that, after the split of Triatoma, Mepraia divided into two main groups similar to 2.1 Mya. The northern group would have speciated between 1.7-1.4 Mya, giving rise to M. parapatrica, M. gajardoi and to a new, still undescribed lineage (Mepraia sp.). The southern group formed M. spinolai similar to 1.68 Mya. We suggest that Mepraia originated from the north-central Andes due to the last Andes uplift and hyperaridity. The hyperarid cycle would have separated the southern and northern groups. Then, within the northern group, colonization would have occurred from the centre to the north and south through corridors influenced by Pleistocene climatic changes. The habitat colonized by the southern clade led to only one species (M. spinolai). Fluctuations in climatic changes probably influenced speciation strongly in this kissing bug in the Atacama Desert. Mepraia is a genus (Triatominae) endemic to Chile and a vector of Trypanosoma cruzi. Alternative phylogeographic hypotheses have been suggested for Mepraia. We tested different colonization routes hypothesized using mitochondrial sequences and phylogeographic approaches to select the best-supported hypothesis. Our results suggest that, after the split from the sister genus Triatoma at similar to 4.3 Mya, Mepraia formed two main clades at similar to 2.1 Mya. The northern clade diverged from Mepraia sp. similar to 1.7 Mya, giving rise to M. parapatrica and M. gajardoi about similar to 1.4 Mya. The southern clade originated M. spinolai similar to 1.68 Mya. We suggest that Mepraia had an origin in the north-central Andes along with orogenic processes, reinforced by hyperaridity during the Pliocene. The hyperarid cycle would have separated the southern and northern clades. Then, in the northern clade, dispersal occurred north and south from the centre through corridors during the Pleistocene Climatic Oscillations. Climate changes may have induced a major speciation process in the Atacama Desert, while the more homogeneous habitat colonized by the southern clade led to only one, but structured, species

    Applicative morphology : neglected syntactic and non-syntactic functions

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    This book is about recurrent functions of applicative morphology not included in typologically-oriented definitions. Based on substantial cross-linguistic evidence, it challenges received wisdom on applicatives in several ways. First, in many of the surveyed languages, applicatives are the sole means to introduce a non-Actor semantic role into a clause. When there is an alternative way of expression, the applicative counterpart often has no valence-increasing effect on the targeted root. Second, applicative morphology can introduce constituents which are not syntactic objects and/or co-occur with obliques. Third, functions such as conveying aspectual nuances to the predicate (intensity, repetition, habituality) or its arguments (partitive P, highly individuated P), narrow-focusing constituents, and functioning as category-changing devices are attested in geographically distant and genetically unrelated languages. Further, this volume reveals that spatial-related morphology is prone to developing applicative functions in disparate languages and phyla. Finally, several contributions discuss the diachrony of applicative constructions and their (non-syntactic) attested functions, including a case of applicatives-in-the-making

    Introduction

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    The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies