10 research outputs found

    Altered cell cycle distribution and replication fork progression in ORC1 knockdown cells.

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    <p>(A) DNA samples from log phase cultures were subjected to neutral-neutral 2D gel analysis following digestion with <i>HindIII</i> and enrichment for RIs on BND cellulose. Left panels: blots were probed with the rDNA 5′ NTS probe (wild type (WT) and ORC1 knockdown (ORC1-KD) strains. Right panel, schematic of the palindromic <i>HindIII</i> fragment spanning the two inverted copies of the 5′ NTS, promoter (pro) and replication origins (D1 and D2). (B) Representative images for DNA fibers sequentially labeled with IdU and CldU. Inter-origin distance and fork velocity were measured in log phase CU428 and ORC1-KD cells (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004875#s4" target="_blank">Materials and Methods</a> for details).</p

    Associations between exposure quartiles for log-transformed concentrations of MEHHP and ∑All monoesters and body fat distribution indices with significant continuous regression coefficients in 8-10yrs boys of China, corrected for puberty onset, socio-economic level, physical activity and dietary nutriment intake.

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    <p>(Blue rhombus: regression coefficient; Error bar: 95% confidence interval; log-transformed indices including subscapular skinfold thickness, triceps skinfold thickness and BF ratio; BMI, BMI z-score, waist circumference, hip circumference, and BSA were normally distributed data)</p

    BMI z-score in relation to urinary phthalate metabolite concentrations, by median (ppb) quartiles for ∑All in 8-10yrs boys (A), MBP and ∑LMP in 11-13yrs boys (B), and ∑MEHP in 8-10yrs girls (C).

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    <p>Obesity and normal weight children were stratified by age- and gender-specific weight distribution based on the national survey in Chinese school children, normal weight children (<80th %) and obesity children (≥90th%), National Puberty Timing and Health Effects in Chinese Children (PTHEC) study, Shanghai 2010-2012.</p

    Associations between exposure quartiles for log-transformed concentrations of MBP and ∑LMP and body fat distribution indices with significant continuous regression coefficients in 11-13yrs boys of China, corrected for puberty onset, socio-economic level, physical activity and dietary nutriment intake.

    No full text
    <p>(Blue rhombus: regression coefficient; Error bar: 95% confidence interval; log-transformed indices including subscapular skinfold thickness, triceps skinfold thickness and BF ratio; BMI, BMI z-score, waist circumference, hip circumference, and BSA were normally distributed data)</p
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