1,009 research outputs found

    Proposal of a VHEE Linac for FLASH radiotherapy

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    Translation of electron FLASH radiotherapy in clinical practice requires the use of high energy accelerators to treat deep tumours and Very High Electron Energy (VHEE) could represent a valid technique to achieve this goal. In this scenario, a VHEE FLASH linac is under study at the University La Sapienza of Rome (Italy) in collaboration with the Italian Institute for Nuclear Research (INFN) and the Institut Curie (France). Here we present the preliminary results of a compact C-band system aiming to reach an high accelerating gradient and an high pulse current necessary to deliver high dose per pulse and ultra-high dose rate required for FLASH effect. We propose a system composed of a low energy high current injector linac followed by a modular section of high accelerating gradient structures. CST code is used to define the required LINAC’s RF parameters and beam dynamics simulations are performed using TSTEP and ASTR

    Harmonic Distortion Aspects in Upper Limb Swings during Gait in Parkinson's Disease

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    Parkinson's disease (PD) is responsible for a broad spectrum of signs and symptoms, including relevant motor impairments generally rated by clinical experts. In recent years, motor measurements gathered by technology-based systems have been used more and more to provide objective data. In particular, wearable devices have been adopted to evidence differences in the gait capabilities between PD patients and healthy people. Within this frame, despite the key role that the upper limbs' swing plays during walking, no studies have been focused on their harmonic content, to which this work is devoted. To this end, we measured, by means of IMU sensors, the walking capabilities of groups of PD patients (both de novo and under-chronic-dopaminergic-treatment patients when in an off-therapy state) and their healthy counterparts. The collected data were FFT transformed, and the frequency content was analyzed. According to the results obtained, PD determines upper limb rigidity objectively evidenced and correlated to lower harmonic contents

    Harmonic Distortion Aspects in Upper Limb Swings during Gait in Parkinson’s Disease

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    Parkinson’s disease (PD) is responsible for a broad spectrum of signs and symptoms, including relevant motor impairments generally rated by clinical experts. In recent years, motor measurements gathered by technology-based systems have been used more and more to provide objective data. In particular, wearable devices have been adopted to evidence differences in the gait capabilities between PD patients and healthy people. Within this frame, despite the key role that the upper limbs’ swing plays during walking, no studies have been focused on their harmonic content, to which this work is devoted. To this end, we measured, by means of IMU sensors, the walking capabilities of groups of PD patients (both de novo and under-chronic-dopaminergic-treatment patients when in an off-therapy state) and their healthy counterparts. The collected data were FFT transformed, and the frequency content was analyzed. According to the results obtained, PD determines upper limb rigidity objectively evidenced and correlated to lower harmonic contents

    The fragmentation trigger of the FOOT experiment

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    FOOT is a fixed target nuclear physics experiment in which O, C and He beams are shot on H enriched targets to study the projectile fragmentations; the measured cross sections will be used in medical physics and radioprotection in space applications. Beam fragmentation happens only on ‚Čą 10% of the cases so it is convenient to develop a sophisticated trigger procedure to veto most of non-fragmented primaries passing through the detector. In this paper we present the developed trigger algorithm operated on a WaveDAQ TDAQ system which is used also as DAQ for three of the FOOT detectors

    A Viscoelastic Model to Evidence Reduced Upper-Limb-Swing Capabilities during Gait for Parkinson’s Disease-Affected Subjects

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    Parkinson’s disease (PD) is a chronic neurodegenerative disorder with high worldwide prevalence that manifests with muscle rigidity, tremor, postural instability, and slowness of movement. These motor symptoms are mainly evaluated by clinicians via direct observations of patients and, as such, can potentially be influenced by personal biases and inter- and intra-rater differences. In order to provide more objective assessments, researchers have been developing technology-based systems aimed at objective measurements of motor symptoms, among which are the reduced and/or trembling swings of the lower limbs during gait tests, resulting in data that are potentially prone to more objective evaluations. Within this frame, although the swings of the upper limbs during walking are likewise important, no efforts have been made to reveal their support significance. To fill this lack, this work concerns a technology-based assessment of the forearm-swing capabilities of PD patients with respect to their healthy counterparts. This was obtained by adopting a viscoelastic model validated via measurements during gait tests tackled as an inverse dynamic problem aimed at determining the torque forces acting on the forearms. The obtained results evidence differences in the forearm movements during gait tests of healthy subjects and PD patients with different pathology levels, and, in particular, we evidenced how the worsening of the disease can cause the worsening of the mechanical support offered by the forearm’s swing to the walking process

    Nuclear physics midterm plan at LNS

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    International audienceThe next years will see the completion of several new facilities at Istituto Nazionale di Fisica Nucleare ‚Äď Laboratori Nazionali del Sud (LNS) opening up new possibilities in the fields of nuclear structure, nuclear dynamics, nuclear astrophysics and applications. These include a new line for high-intensity cyclotron beams, a new facility for in-flight production of radioactive ion beams, the PANDORA plasma trap for multidisciplinary studies and a high-power laser for basic science and applied physics. The nuclear physics community has organized a workshop to discuss the new physics opportunities that will be possible in the middle term (5‚Äď7 years) by employing state-of-the-art detection systems. A detailed discussion of the outcome from the workshop is presented in this report

    New national and regional Annex I Habitat records: from #60 to #82

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    New Italian data on the distribution of the Annex I Habitats are reported in this contribution. Specifically, 8 new occurrences in Natura 2000 sites are presented and 49 new cells are added in the EEA 10 km √ó 10 km reference grid. The new data refer to the Italian administrative regions of Campania, Calabria, Marche, Piedmont, Sardinia, Sicily, Tuscany and Umbria. ReleveŐĀs and figures are provided as Supplementary material respectively 1 and 2. Copyright Antonio Morabito et al

    Nuclear physics midterm plan at LNS

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    TOPS fast timing plastic scintillators: time and light output performances

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    Organic plastic scintillators are largely exploited for fast timing detectors thanks to their short scintillation time with respect to inorganic crystals. Plastic scintillators are cheap to produce, light and easy to manipulate (any standard mechanical workshop can handle the cutting, polishing, etc.). Nowadays, fastest plastic scintillators available on the market are EJ-232 (Eljen Technology) and BC-422 (Saint Gobain) with a rise time of 350 ps, a decay time of 1.6 ns and a pulse width of 1.3 ns. Foreseen the performance improvement of timing detectors based on plastic scintillators, the development of faster scintillators can give a crucial contribution. TOPS is a project focused on the development of a new class of organic scintillators producing several liquid and solid samples. Comparing the light output and the timing properties of the samples exploiting minimum ionising particles, a selection of the highly performing TOPS scintillators has been investigated and characterised. The performance achieved with TOPS samples are extremely promising: a time resolution improvement from 10 up to 35% with respect to the EJ-232 has been demonstrated. In addition, an increase of light output has been obtained for all samples with a consequent potential improvement in energy resolution measurements of a factor up to 35%

    Elemental fragmentation cross sections for a O-16 beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT Delta E-TOF detectors

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    The study of nuclear fragmentation plays a central role in many important applications: from the study of Particle Therapy (PT) up to radiation protection for space (RPS) missions and the design of shielding for nuclear reactors. The FragmentatiOn Of Target (FOOT) collaboration aims to study the nuclear reactions that describe the interactions with matter of different light ions (like H-1, He-4, C-12, O-16) of interest for such applications, performing double differential fragmentation cross section measurements in the energy range of interest for PT and RPS. In this manuscript, we present the analysis of the data collected in the interactions of an oxygen ion beam of 400 MeV/u with a graphite target using a partial FOOT setup, at the GSI Helmholtz Center for Heavy Ion Research facility in Darmstadt. During the data taking the magnets, the silicon trackers and the calorimeter foreseen in the final FOOT setup were not yet available, and hence precise measurements of the fragments kinetic energy, momentum and mass were not possible. However, using the FOOT scintillator detectors for the time of flight (TOF) and energy loss (Delta E) measurements together with a drift chamber, used as beam monitor, it was possible to measure the elemental fragmentation cross sections. The reduced detector set-up and the limited available statistics allowed anyway to obtain relevant results, providing statistically significant measurements of cross sections eagerly needed for PT and RPS applications. Whenever possible the obtained results have been compared with existing measurements helping in discriminating between conflicting results in the literature and demonstrating at the same time the proper functioning of the FOOT Delta E-TOF system. Finally, the obtained fragmentation cross sections are compared to the Monte Carlo predictions obtained with the FLUKA software
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