5 research outputs found

    TYT Curve : Pilot Study on Alternatives Standards of Reference to Determine Intrauterine Growth in Low Resource Setting In Indonesia

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    Objective: To develop a new intrauterine growth curve based on local population for accurate intrauterine growth retardation (IUGR) infant identification. Methods: An observational analytic method was applied to develop Tina-Yessika-Tetty (TYT) curve derived from 13,405 neonatal anthropometric measurements taken from the medical record database of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The infants included in this study were born during the period of January 1st, 2005 to December 31st, 2009. The new curve was then compared to the Lubchenco and Alisjahbana curves. Only 6,814 data met the inclusion and exclusion criteria.    Results: The mean birth weight in this study was lower compared to that of the Lubchenco and Alisjahbana studies. Comparison of the three curves showed that there was a significant difference among the three curves (R=0.998, R2=0.996, p<0.001), which indicates a probability for a newborn classification.Conclusions: TYT curve may be used as an alternative to identify IUGR immediately after birth, especially when detection during pregnancy is not available in low resource setting. A prospective study with a larger population is needed; However, this study has provided an evidence to support the need for timely evaluation for such growth chart as they change over time.    Keywords: Alisjahbana curve, intrauterine growth, Lubchenco curve, TYT curveDOI: 10.15850/ijihs.v2n1.27

    TYT CURVE : PILOT STUDY ON ALTERNATIVES STANDARDS OF REFERENCE TO DETERMINE INTRAUTERINE GROWTH IN LOW RESOURCE SETTING IN INDONESIA

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    Objective: To develop a new intrauterine growth curve based on local population for accurate intrauterine growth retardation (IUGR) infant identification. Methods: An observational analytic method was applied to develop Tina-Yessika-Tetty (TYT) curve derived from 13,405 neonatal anthropometric measurements taken from the medical record database of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The infants included in this study were born during the period of January 1st, 2005 to December 31st, 2009. The new curve was then compared to the Lubchenco and Alisjahbana curves. Only 6,814 data met the inclusion and exclusion criteria. Results: The mean birth weight in this study was lower compared to that of the Lubchenco and Alisjahbana studies. Comparison of the three curves showed that there was a significant difference among the three curves (R=0.998, R2=0.996, p<0.001), which indicates a probability for a new newborn classification. Conclusions: TYT curve may be used as an alternative to identify IUGR immediately after birth, especially when detection during pregnancy is not available in low resource setting. A prospective study with a larger population is needed; However, this study has provided an evidence to support the need for timely evaluation for such growth chart as they change over time

    Validitas Skoring Hematologi Rodwell Untuk Deteksi Dini Sepsis Neonatorum Awitan Dini

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    Latar belakang. Sepsis neonatorum awitan dini adalah sindrom klinis dengan gejala infeksi sistemik yang merupakan penyebab utama kesakitan dan kematian pada neonatus. Diagnosis sepsis neonatorum seringkali sulit karena gejala klinisnya tidak khas. Pemeriksaan biakan darah sebagai baku emas, memerlukan waktu 48-72 jam. Sistem skoring hematologi (SSH) Rodwell dapat digunakan sebagai alat bantu deteksi dini sepsis neonatorum awitan dini. Tujuan. Menentukan nilai sensitivitas dan spesifisitas SSH Rodwell dalam mendeteksi sepsis neonatorum awitan dini. Metode. Penelitian deskriptif dengan rancangan potong lintang dilakukan di RSUP dr. Hasan Sadikin Bandung antara bulan September sampai November 2013. Subjek penelitian adalah neonatus berumur kurang atau sama dengan 5 hari dengan faktor risiko sepsis neonatorum. Hasil. Pada neonatus ditemukan hasil biakan darah positif 45 (40,9%) subjek. Sistem skoring hematologi Rodwell memiliki sensitivitas 100% dan spesifisitas 66% untuk mendeteksi sepsis neonatorum awitan dini. Kesimpulan. Pemeriksaan SSH Rodwell memiliki nilai sensitivitas tinggi dan nilai spesifisitas sedang dalam menegakkan diagnosis sepsis neonatorum awitan dini

    Impact of Bifidobacterium lactis supplementation on fecal microbiota in infants delivered vaginally compared to Caesarean section

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    Background It has been reported that infants born by Caesarean section have altered gut microbiota, with lower n umbers of bifidobacteria and Bacteroides, compared to that of infants who were delivered vaginally. Probiotic supplementation has been reported to have beneficial effects on the immune response, generally in relation to allergies. Objective To assess the effect of Bifidobacterium lactis (B. lactis) supplementation on the presence of B. lactis and bifidobacteria counts in stool of infants during the first 2 months of life . Methods We conducted an observational study of 122 healthy, breast-fed infants delivered vaginally or by Caesarean section. Infants assigned to the test group received breast milk and formula supplemented with the B. lactis probiotics. Infants in the control group received breast milk and formula without probiotics. The presence of B. lactis and stool bifidobacteria counts were determined at 1 month and 2 months of age. Growth, morbidity, serum immune markers, and stool immunoglobulin (lg) A were also assessed. Results B. lactis was more frequently detected in the stool of infants who received breast milk and probiotic-supplemented formula than in stool of infants who received breast milk and non-supplemented formula, both at 1 month and 2 months of age (OR 1,263; 95%Cl 11 to 15 1,030; P=0.003) . Of infants who received probiotic-supplemented formula, B. lactis was detected in 80% of those delivered by Caesarean section and in 3 8% of those delivered vaginally, at the 1-month mark. In infants delivered by Caesarean section, the mean stool bifidobacteria level at 1 month was significantly higher in the probiotic-supplemented group compared to that of the non-supplemented group (P=0.021) . Conclusion Early bifidobacteria supplementation of infants, particularly those delivered by Caesarean section, is associated with higher levels of stool bifidobacteria. Anthropometric data suggests beneficial effect s of bifidobacteria supplementation on infant growth, though most are not statistically significant
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