Alien Registration- Slonina, Juliana M. (Winthrop, Kennebec County)

https://digitalmaine.com/alien_docs/17078/thumbnail.jp

Territorial study of the site for the hospital, Hodonín

Import 13/01/2017Cílem diplomové práce je navrhnout prostorové a funkční využití lokality Za nemocnicí v Hodoníně Diplomová práce je vypracovaná v rozsahu územní studie s urbanistickým řešením zástavby ve variantách. Pro zvolenou variantu byly zpracovány návrhy vedení inženýrských sítí a navrženo dopravní řešení. Využití pozemku bylo upraveno podmínkami a regulacemi obsaženými v textové části a podrobně prostorově popsáno, včetně jednotlivých budov. Na závěr byl provedený typologický návrh objemové studie navrženého bytového domu spolu s vizualizacemi varianty.The aim of this diploma thesis is a design the planning and functional usage of territorial studies of the site for hospital, Hodonin. This thesis is elaborated in the range of territorial studies with urban solution in the variants. For the selected variant were processed proposals of technical designed and transport solutions. Territorial determining regulations has been modified terms and conditions contained in the text part of the thesis described, including design individual buildings. At the end of thesis was made typological proposal studies designed apartment building along with visualization of variant.222 - Katedra městského inženýrstvívelmi dobř

What can we learn from inactivation studies? Lessons from auditory cortex

Wide variation in the outcome of auditory cortex inactivation has been an impediment to clear conclusions regarding the roles of the auditory cortex in behaviour. Inactivation methods differ in their efficacy and specificity. The likelihood of observing a behavioural deficit is additionally influenced by factors such as the species being used, task design and reward. A synthesis of previous results suggests that auditory cortex involvement is critical for tasks that require integrating across multiple stimulus features, and less likely to be critical for simple feature discriminations. New methods of neural silencing provide opportunities for spatially and temporally precise manipulation of activity, allowing perturbation of individual subfields and specific circuits

Moravian Ostrava - typological design of a multifunctional building in a gap Šubertova x Hollarova Streets

Import 23/07/2015Předmětem této práce je návrh polyfunkčního domu v proluce nároží ulic Hollarovy a Šubertovy v Moravské Ostravě. Práce je řešena v rozsahu objemové studie, která řeší typologický návrh, statickou dopravu a zohledňuje požadavky na bezbariérové užívání staveb. Daná práce se snaží vyřešit problémy vyplívající z polohy řešené lokality v městské památkové zóně, omezení zásadami platné územně plánovací dokumentace, návaznost na stávající zástavbu, problematiku parkování a další úskalí. Nedílnou součástí práce je orientační propočet navrhovaného řešení.The subject of this thesis is to develop of a multifunctional building in the corner of a vacant of Hollarova and Šubertova streets in Moravian Ostrava. This thesis is in the range of volume study that solved typological design, static traffic and takes into account the requirements for barrier-free use of buildings. Given work trying to solve problems revenues resulting from a position designed sites in the municipal preservation area, restrictions applicable principles of planning documentation, lines up to existing buildings, parking issues and other problems. An integral part of the thesis is the approximate calculation of the proposed solution.222 - Katedra městského inženýrstvívelmi dobř

26. Chromosomal damage and survival of keratinocytes and fibroblasts after irradiation with 200 kV or 25 kV X-rays

A relative biological effectiveness of 1 is accepted for soft X-rays (25–30 kV), which are applied in diagnostic radiology (mammography). However, it has been shown that soft X-rays can be more effective in cell killing and chromosomal damage. The present study was initiated to define biological effects of low-energy X-rays in vitro. Experiments were performed with 25 kV X-rays and 200 kV reference X-rays on neonatal human keratinocytes (HEKn), and NIH/3T3 mouse fibroblasts. Cell survival was studied with graded doses in a clonogenic assay, chromosomal damage in a micronucleus (MN) assay. The surviving fraction at 2 Gy for keratinocytes was 46±5% after 200 kV and 33±11% after 25 kV X-rays. Linear-quadratic cell survival analysis yielded α=0.305±0.033 Gy-1 and β=0.048±0.011 Gy-2 for 200 kV and α=0.399±0.103 Gy-1 and β=0.048±0.054 Gy-2 for 25 kV. For 3T3 fibroblasts an SF2 of 53±3% after 200 kV and 61±18% after 25 kV was observed. Values of α=0.24±0.02 Gy-1 and β=0.022±0.002 Gy-2 for 200 kV and α=0.10±0.05 Gy-1 and β=0.070±0.010 Gy-2 for 25 kV were derived. In conclusion, keratinocyte survival was similar for both radiation qualities. For fibroblasts, a reduction in survival at higher doses was observed. Results from MN studies will be presented

15.Radiation survival and colony size of human epidermal keratinocytes in the presence of keratinocyte growth factor (rhKGF)

The capacity of recombinant human keratinocyte growth factor (rhKGF) to ameliorate the radiation response of mouse oral mucosa and other epithelial tissues was recently reported. However, the exact mechanisms of action of KGF remain unclear. The aim of the present study was to investigate the effect of rhKGF on survival and colony size of normal human epidermal keratinocytes in vitro. Primary human neonatal keratinocytes (HEKn) were irradiated with doses of 0 Gy and 2 Gy (200 kV X-rays) and incubated in the presence or absence of 100ng/ml rhKGF. Plating efficiency (PE) and surviving fraction (SF2) were determined in a clonogenic assay. In cell cultures without rhKGF the mean PE was 4.6%. Irradiation with 2 Gy resulted in a SF2 of 51%. In cell cultures with rhKGF, the mean PE was identical (4.6%). After irradiation with 2 Gy, a similar SF2 of 54% was observed, indicating that KGF did not change the survival characteristics of HEKn keratinocytes. Individual colony size, however, in all cultures incubated with rhKGF was significantly increased compared to incubation without rhKGF. The number of extremely large colonies (□2 mm) was clearly higher (p=0.0000) with rhKGF-containing culture medium. In conclusion, rhKGF does not affect keratinocyte survival after irradiation, but stimulates proliferation of surviving cells

On the HU Aquarii planetary system hypothesis

In this work, we investigate the eclipse timing of the polar binary HU Aquarii that has been observed for almost two decades. Recently, Qian et al. attributed large (O-C) deviations between the eclipse ephemeris and observations to a compact system of two massive jovian companions. We improve the Keplerian, kinematic model of the Light Travel Time (LTT) effect and re-analyse the whole currently available data set. We add almost 60 new, yet unpublished, mostly precision light curves obtained using the time high-resolution photo-polarimeter OPTIMA, as well as photometric observations performed at the MONET/N, PIRATE and TCS telescopes. We determine new mid--egress times with a mean uncertainty at the level of 1 second or better. We claim that because the observations that currently exist in the literature are non-homogeneous with respect to spectral windows (ultraviolet, X-ray, visual, polarimetric mode) and the reported mid--egress measurements errors, they may introduce systematics that affect orbital fits. Indeed, we find that the published data, when taken literally, cannot be explained by any unique solution. Many qualitatively different and best-fit 2-planet configurations, including self-consistent, Newtonian N-body solutions may be able to explain the data. However, using high resolution, precision OPTIMA light curves, we find that the (O-C) deviations are best explained by the presence of a single circumbinary companion orbiting at a distance of ~4.5 AU with a small eccentricity and having ~7 Jupiter-masses. This object could be the next circumbinary planet detected from the ground, similar to the announced companions around close binaries HW Vir, NN Ser, UZ For, DP Leo or SZ Her, and planets of this type around Kepler-16, Kepler-34 and Kepler-35.Comment: 20 pages, 18 figures, accepted to Monthly Notices of the Royal Astronomical Society (MNRAS