22 research outputs found

    Comparison of the number of segments having PSS (left) and the average value of PSS (right) between HOCM patients before and half a year after septal ablation.

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    <p>Comparison of the number of segments having PSS (left) and the average value of PSS (right) between HOCM patients before and half a year after septal ablation.</p

    Clinical characteristics of study participants.

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    <p>HOCM, hypertrophic obstructive cardiomyopathy; HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; NYHA, New York Heart Association.</p

    The relationship between the reductions in the average value of PSS and the changes in the E-to-Ea ratio in HOCM patients at half a year after a PTSMA procedure.

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    <p>The relationship between the reductions in the average value of PSS and the changes in the E-to-Ea ratio in HOCM patients at half a year after a PTSMA procedure.</p

    Conventional echocardiographic characteristics of healthy controls and HOCM patients at baseline and half a year after PTSMA.

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    <p>*, P value of comparing between control subjects and HOCM patients at baseline; &, P value of comparing between HOCM patients at baseline and HOCM patients at half a year after PTSMA; HOCM, hypertrophic obstructive cardiomyopathy; LVPW, left ventricular posterior wall; maxLVT,maximal left ventricular thickness;LAV, left atrial volume; LVEF, left ventricular ejection fraction; LVOT, left ventricular outflow tract; DT, E deceleration time; IVRT, isovolumic relaxation time.</p

    Strain curves from the apical 4-chamber view at baseline (A) and half a year after successful septal ablation (B) in a HOCM patient.

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    <p>The number of segments having PSS was significantly reduced at half a year after PTSMA. <b><i>Arrows</i></b>, Strain curves showing postsystolic shortening (PSS).</p

    Table_1_Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy.DOCX

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    BackgroundThis study aimed to explore the effect of sex on left atrial (LA) remodeling and its relationship with myocardial fibrosis in patients with hypertrophic obstructive cardiomyopathy (HOCM).Methods and resultsA total of 85 patients with HOCM were enrolled. Myocardial fibrosis was quantified by the collagen volume fraction (CVF) in myocardial samples. The early atrial peak of emptying rate (PER-E) was assessed by LA volume/time (V/t) curves derived from cardiac magnetic resonance (CMR) imaging analysis. The PER-E index was PER-E normalized by left ventricular (LV) filling volume. Patients with HOCM showed a lower PER-E index than healthy controls (P = 0.027). Compared with men, the PER-E (P 0.05). The CVF was correlated with the PER-E and PER-E indexes in both sexes (all P-values were ConclusionPatients with HOCM presented LA reverse remodeling. Impaired LA function was more common in female patients with HOCM due to their susceptibility to myocardial fibrosis.</p

    Predictive Values of N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin I for Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy

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    <div><p>Background</p><p>Both high-sensitivity cardiac troponin T and B-type natriuretic peptide are useful in detecting myocardial fibrosis, as determined by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR), in patients with non-obstructive hypertrophic cardiomyopathy. However, their values to predict myocardial fibrosis in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. We investigated the role of N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and cardiac troponin I (cTnI) to identify LGE-CMR in patients with HOCM.</p><p>Methods</p><p>Peripheral concentrations of NT-proBNP and cTnI were determined in patients with HOCM (n = 163; age = 47.2 ± 10.8 years; 38.7% females). Contrast-enhanced CMR was performed to identify and quantify myocardial fibrosis.</p><p>Results</p><p>LGE was detected in 120 of 163 patients (73.6%). Patients with LGE had significantly higher levels of NT-proBNP and cTnI than those without LGE (1386.2 [904.6–2340.8] vs. 866.6 [707.2–1875.2] pmol/L, P = 0.003; 0.024 [0.010–0.049] vs. 0.010 [0.005–0.021] ng/ml, P <0.001, respectively). The extent of LGE was positively correlated with log cTnI (r = 0.371, P <0.001) and log NT-proBNP (r = 0.211, P = 0.007). On multivariable analysis, both log cTnI and maximum wall thickness (MWT) were independent predictors of the presence of LGE (OR = 3.193, P = 0.033; OR = 1.410, P < 0.001, respectively), whereas log NT-proBNP was not. According to the ROC curve analysis, combined measurements of MWT ≥21 mm and/or cTnI ≥0.025ng/ml indicated good diagnostic performance for the presence of LGE, with specificity of 95% or sensitivity of 88%.</p><p>Conclusions</p><p>Serum cTnI is an independent predictor useful for identifying myocardial fibrosis, while plasma NT-proBNP is only associated with myocardial fibrosis on univariate analysis. Combined measurements of serum cTnI with MWT further improve its value in detecting myocardial fibrosis in patients with HOCM.</p></div

    Expression profiles of plasma miR-122, -140-3p, -720, -2861, and -3149 in ACS and non-ACS patients in the training data set.

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    <p>A total of 539 plasma samples were used for the training data set in deriving the miRNA panel for use in the classification of ACS and non-ACS. The expression levels of miR-122, -140-3p, -720, -2861, and -3149 were dramatically elevated in the ACS (UA + AMI) group compared with the non-ACS (non-CHD + SA) group (A to E). The determination values of these five plasma miRNAs were analyzed by ROC curves (F). Abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125430#pone.0125430.g001" target="_blank">Fig 1</a>.</p
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