632 research outputs found

    Data File.xlsx

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    The data set consists of raw data used for data analysis. The questionnaire consists of measurement items used to collect data from respondents.</p

    Are Nonalcoholic Fatty Liver Disease and Bone Mineral Density Associated? — A Cross‐Sectional Study Using Liver Biopsy and Dual‐Energy X‐Ray Absorptiometry

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    ABSTRACT There is controversy regarding the association between nonalcoholic fatty liver disease (NAFLD) and osteoporosis. Our study aim was to assess bone mineral density (BMD) in patients with biopsy‐proven NAFLD and examine if the severity of NAFLD affects BMD. A total of 147 adult women (n = 108) and men (n = 39) aged 18–76 years (mean ± standard deviation [SD] age 45.3 ± 12.5) were recruited in this cross‐sectional study and underwent a liver biopsy and dual‐energy X‐ray absorptiometry (DXA). NAFLD activity score (NAS) based on the degree of steatosis, lobular inflammation and hepatocellular ballooning was used to assess NAFLD severity. The majority of subjects, 53%, had steatosis, 25% had nonalcoholic steatohepatitis (NASH) whereas 23% served as control subjects with no evidence of NAFLD. There were no significant differences in the lumbar spine (1.09 ± 0.12, 1.11 ± 0.18, and 1.12 ± 0.15 g/cm2, p = 0.69, in controls, steatosis, and NASH, respectively) or hip BMD (1.10 ± 0.15, 1.12 ± 0.13, and 1.09 ± 0.13 g/cm2, p = 0.48, in controls, steatosis, and NASH, respectively) between the groups. Adjusting for age, gender, body mass index, and diabetes in multiple regression models did not alter the results. There was no correlation between NAS and neither lumbar spine BMD (r = 0.06, p = 0.471), nor hip BMD (r = −0.03, p = 0.716). In conclusion, BMD was similar across the spectrum of NAFLD in both genders and not related to the severity of the underlying histological lesions, suggesting that neither steatosis nor NASH exerts a detrimental effect on BMD in these relatively young patients. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research

    Data File.xlsx

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    The data file consists of demographic details of respondents and also responses pertaining to specific questions</p

    CoVE: Towards Confidential Computing on RISC-V Platforms

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    Multi-tenant computing platforms are typically comprised of several software and hardware components including platform firmware, host operating system kernel, virtualization monitor, and the actual tenant payloads that run on them (typically in a virtual machine, container, or application). This model is well established in large scale commercial deployment, but the downside is that all platform components and operators are in the Trusted Computing Base (TCB) of the tenant. This aspect is ill-suited for privacy-oriented workloads that aim to minimize the TCB footprint. Confidential computing presents a good stepping-stone towards providing a quantifiable TCB for computing. Confidential computing [1] requires the use of a HW-attested Trusted Execution Environments for data-in-use protection. The RISC-V architecture presents a strong foundation for meeting the requirements for Confidential Computing and other security paradigms in a clean slate manner. This paper describes a reference architecture and discusses ISA, non-ISA and system-on-chip (SoC) requirements for confidential computing on RISC-V Platforms. It discusses proposed ISA and non-ISA Extension for Confidential Virtual Machine for RISC-V platforms, referred to as CoVE

    Nalanda: a socio-technical graph platform for building software analytics tools at enterprise scale

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    Software development is information-dense knowledge work that requires collaboration with other developers and awareness of artifacts such as work items, pull requests, and file changes. With the speed of development increasing, information overload and information discovery are challenges for people developing and maintaining these systems. Finding information about similar code changes and experts is difficult for software engineers, especially when they work in large software systems or have just recently joined a project. In this paper, we build a large scale data platform named Nalanda platform to address the challenges of information overload and discovery. Nalanda contains two subsystems: (1) a large scale socio-technical graph system, named Nalanda graph system, and (2) a large scale index system, named Nalanda index system that aims at satisfying the information needs of software developers. To show the versatility of the Nalanda platform, we built two applications: (1) a software analytics application with a news feed named MyNalanda that has Daily Active Users (DAU) of 290 and Monthly Active Users (MAU) of 590, and (2) a recommendation system for related work items and pull requests that accomplished similar tasks (artifact recommendation) and a recommendation system for subject matter experts (expert recommendation), augmented by the Nalanda socio-technical graph. Initial studies of the two applications found that developers and engineering managers are favorable toward continued use of the news feed application for information discovery. The studies also found that developers agreed that a system like Nalanda artifact and expert recommendation application could reduce the time spent and the number of places needed to visit to find information. Publisher Copyright: © 2022 ACM.Software Technolog

    Nalanda: a socio-technical graph platform for building software analytics tools at enterprise scale

    No full text
    Software development is information-dense knowledge work that requires collaboration with other developers and awareness of artifacts such as work items, pull requests, and file changes. With the speed of development increasing, information overload and information discovery are challenges for people developing and maintaining these systems. Finding information about similar code changes and experts is difficult for software engineers, especially when they work in large software systems or have just recently joined a project. In this paper, we build a large scale data platform named Nalanda platform to address the challenges of information overload and discovery. Nalanda contains two subsystems: (1) a large scale socio-technical graph system, named Nalanda graph system, and (2) a large scale index system, named Nalanda index system that aims at satisfying the information needs of software developers. To show the versatility of the Nalanda platform, we built two applications: (1) a software analytics application with a news feed named MyNalanda that has Daily Active Users (DAU) of 290 and Monthly Active Users (MAU) of 590, and (2) a recommendation system for related work items and pull requests that accomplished similar tasks (artifact recommendation) and a recommendation system for subject matter experts (expert recommendation), augmented by the Nalanda socio-technical graph. Initial studies of the two applications found that developers and engineering managers are favorable toward continued use of the news feed application for information discovery. The studies also found that developers agreed that a system like Nalanda artifact and expert recommendation application could reduce the time spent and the number of places needed to visit to find information. </p

    A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment

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    The implementation of immunotherapy has radically changed the treatment of oncological patients. Currently, immunotherapy is indicated in the treatment of patients with head and neck tumors, melanoma, lung cancer, bladder tumors, colon cancer, cervical cancer, breast cancer, Merkel cell carcinoma, liver cancer, leukemia and lymphomas. However, its efficacy is restricted to a limited number of cases. The challenge is, therefore, to identify which subset of patients would benefit from immunotherapy. To this end, the establishment of immunotherapy response criteria and predictive and prognostic biomarkers is of paramount interest. In this report, a group of experts of the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Medical Radiology (SERAM), and Spanish Society of Nuclear Medicine and Molecular Imaging (SEMNIM) provide an up-to-date review and a consensus guide on these issues

    Impact of a Centrebody On the Unsteady Flow Dynamics of a Swirl Nozzle: Intermittency of PVC Oscillations

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    Abstract The precessing vortex core (PVC) is a self-excited flow oscillation state occurring in swirl nozzles. This is caused by the presence of a marginally unstable hydrodynamic helical mode that induces precession of the vortex breakdown bubble (VBB) around the flow axis. The PVC can impact emissions and thermoacoustic stability characteristics of combustors in various ways, as several prior studies have shown. In this paper, we examine the impact of centerbody diameter (Dc) on the PVC in a nonreacting flow in a single nozzle swirl combustor. Time-resolved high-speed stereoscopic PIV measurements are performed for combinations of two swirl numbers, S = 0.67 and 1.17 and Dc = 9.5 mm, 4.73 mm, and 0 (i.e., no centerbody). The bulk flow velocity at the nozzle exit plane is kept constant as Ub = 8 m/s for all cases (Re∼20,000). The centerbody end face lies in the nozzle exit plane. A new modal decomposition technique based on wavelet filtering and proper orthogonal decomposition provides insight into flow dynamics in terms of global modes extracted from the data. The results show that without a centerbody, a coherent PVC is present in the flow as expected. The introduction of a centerbody makes the PVC oscillations intermittent. These results suggest two routes to intermittency as follows. For S = 0.67, the VBB and centerbody wake recirculation zone regions are nominally distinct. Intermittent separation and merger due to turbulence result in PVC oscillations due to the destabilization of the hydrodynamic VBB precession mode of the flow. In the S = 1.17 case, the time averaged VBB position causes it to engulf the centerbody. In this case, the emergence of intermittent PVC oscillations is a result of the response of the flow to broadband stochastic forcing imposed on the time averaged vorticity field due to turbulence.</jats:p

    Wounded Attachments to Disaster Recovery : Gendered Structural Violence and Everyday life, Indian Experiences Explored

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    In this paper, we suggest that theorising on gendered structural violence and inequalities in disaster recovery would benefit from the in-depth focus on intersections of social relations and processes as they manifest in everyday lives. Drawing from the theorising on neoliberal states, we propose a new theoretical approach of "wounded attachments to disaster recovery". This theoretical position is informed by the lives of three women survivors from three diverse disasters in India. Five perspectives on gendered disaster recovery experience is then presented: firstly, how the recovery beneficiary categories are an extension of the neoliberal subject position; secondly, how recovery reinforces gendered responsibilities as "building oneself back better", a respectable mother and provider; thirdly, how recovery causes pain, suffering, and ressentiment; fourthly, how complex inequalities and social relations are lived through and negotiated in the aftermath of disasters; and finally, how women narrate counter cultural everydayness to disaster recovery in their life histories. We suggest that an understanding of intersectionality, or interlocking systems of oppression, as a form of injury, allows to understand power and structures of disaster recovery. Reiterations of such injuries suggest that instead of reducing vulnerability, and injustice, recovery efforts reiterate these very structures of inequality. The failure to operationalize and capture the complexities of structural inequality and injustice in the context of disaster recovery could be overcome by drawing on the work of scholars who recognise the limits of the concept of intersectionality and engage in alternate conceptualizations, such as pain, suffering, trauma and wounded attachments.Peer reviewe
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