1,281 research outputs found

    Using Shabby Chic Style in Contemporary Clothing Accessories to Achieve the Principles of Sustainable Development

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    The research team is keen to provide a new thinking approach characterized by creativity and innovation to achieve the principles of sustainable development, both environmentally and economically. Thus, the team thought about how to preserve the environment by using worn-out clothes and accessories that are not usable again or through recycling instead of disposing of them permanently in a way that harms the environment while emphasizing the economic aspect and reducing the cost. The research team invented artworks with an antique touch as accessories to contemporary clothes, based on the Shabby Chic style, which is one of the economical styles that reuses old worn-out items and mixes them with simple modern ones to create an atmosphere of simplicity and elegance. It is a method used in interior design that combines elements of old furniture with simple design, soft colors, and classic touches that give the house a comfortable and attractive atmosphere. This is the reason why the research team applied the rules of this style with clothes and their accessories attempting to provide inexpensive and creative solutions to be the basis of a small successful project that goes with the new trend of entrepreneurship, in line with the events that the whole world is witnessing nowadays; and this is the most prominent goal of the research. The research followed the descriptive approach with analysis and application. It included a questionnaire to measure the opinions of experts about the suggested designs, and a questionnaire to identify the opinions of consumers about the suggested designs as well. The findings suggest that Shabby Chic Style could be used to create contemporary designs for clothing accessories that meet the principles of sustainable development and entrepreneurship

    Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12

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    The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca2+) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP sensitivity to the TPC complex. We investigated whether and how the NAADP-binding proteins Jupiter microtubule-associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12) contributed to NAADP-TPC-Ca2+ signaling in human cells. Biochemical and functional analyses revealed that recombinant JPT2 and LSM12 both bound to NAADP with high affinity and that endogenous JPT2 and LSM12 independently associated with TPC1 and TPC2. On the basis of knockout and rescue analyses, both NAADP-binding proteins were required to support NAADP-evoked Ca2+ signaling and contributed to endolysosomal trafficking of pseudotyped coronavirus particles. These data reveal that the NAADP-binding proteins JPT2 and LSM12 convergently regulate NAADP-evoked Ca2+ release and function through TPCs

    Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study

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    BACKGROUND: Fine particulate matter (PM 2:5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM 2:5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM 2:5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N 2 MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM 2:5 mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OP DTT v (0:89 nmol=min=m 3) was associated with a decrease in functional residual capacity (FRC) measured by N 2 MBW [b = − 2:26 mL; 95% confidence interval (CI): −4:68, 0.15]. Associations with PM 2:5 showed similar patterns in comparison with OP DTT v but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs 7-19) from AOS tended to be associated with higher OP DTT

    Key messages and partnerships to raise awareness and improve outcomes for people with asthma and COPD in low- and middle-income countries.

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    This is the author accepted manuscript. The final version is available from the International Union Against Tuberculosis and Lung Disease via the DOI in this record

    Structural accreditation of healthcare facilities: comparison of the requirements by Italian Presidential Decree 14/01/1997 and regional regulations. A proposal for updating the minimum environmental units at national level A proposal for updating the minimum environmental units at national level

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    Background and aim. The Decree of the President of the Italian Republic 14/01/1997 is the reference norm related to the accreditation of public and private healthcare structures. This guideline establishes the minimum structural, technological and organizational requirements that each structure operating in the Italian territory must comply with. Methods. In occasion of the project work for the postgraduate training course in healthcare management by ALTEMS School, a team of researchers conducted a survey on the state of updating of the minimum structural requirements indicated in the norm-in particular those relating to hospital facilities- with those adopted by the individual regions through the analysis of the most up-to-date regional regulations. Results. Precisely starting from the comparison of regional references and from the regulations on the subject of structural accreditation which suggest strategic environmental units and which address some key-aspects relating to the contemporary design of healing environments (i.e. semi-intensive care units, hybrid operating theatres, etc.), the outcome of the project work is to define a proposal to update the national reference document, also in the light of the currently changing needs in terms of hospital design. Conclusions. The research aims to become a starting milestone for future investigations. The team investigated – in this first phase – the functional areas listed in the norm, and the next step aims to extend the analysis also to the innovative functions (i.e. buffer spaces, hybrid operating theatres, sub-intensive care units, etc.) and/or introduced only the last years which have only been regulated in some regions

    Paratesticular leiomyoma: A case report of a rare entity

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    Paratesticular leiomyoma is an extremely rare benign tumour. It is often asymptomatic. It is sometimes difficult to distinguish leiomyomas from malignant testicular tumours, which leads to radical orchidectomy, despite its benign nature. Magnetic resonance imaging can be helpful to make conservative management of this lesion

    The Effectiveness of a Suggested E-learning Program Using Keeler’s Strategy to Build a Basic Model for a Girl’s Dress in an Innovative Way

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    The process of preparing patterns is considered one of the most accurate and important jobs on which the ready-made garment industry relies, as the success of the design and production depends entirely on it. Children’s patterns are among the most important types of patterns, whose control and method of construction affects the comfort of the child, which calls on researchers to continuously develop ways to build these patterns. It is characterized by exactness and ease of construction and learning, and after many studies have proven the effectiveness of electronic educational and training programs with appropriate education strategies in learning to prepare patterns. The pattern, and the use of Keelers strategy to master his learning, and the research followed the descriptive approach, and the applied approach. The child achieves excellent control over the body for all sizes, according to the opinions of the arbitrators, where The value of the quality coefficient for adjusting sizes ranged between (94.13) to (95.07), which represents a high degree of acceptance (excellent), and the value of the quality coefficient for adjusting (front, side, back, sleeve) for different sizes ranged between (93.94) to (94.74), which represents A high degree of acceptance (excellent), and the evaluation of the proposed program achieved an excellent evaluation according to the opinions, achieving the arithmetic mean (4.93), and the relative weight (98.67). Finally, the training program achieved a significant impact on the level of knowledge and skill achievement of the trainees

    A juxtaglomerular cell tumor revealed by a hemorrhagic stroke. A case report

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    With about 110 cases reported in literature, juxtaglomerular cell tumors are rare. We report a 25 years old patient who was admitted in neurology for a hemorrhagic stroke secondary to a cerebral aneurysm rupture due to high blood pressure. Etiological investigations showed a solid mass of the left kidney. A radical nephrectomy was realized and pathological examination and immunohistochemical profile concluded to juxtaglomerular cell tumor. The originality of this observation is based on the mode of presentation of a rare renal tumor by a malignant high blood pressure

    A synchrotron transmission X-ray microscopy study on precipitate evolution during solid-state thermal cycling of a stainless steel

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    International audienceDuring additive manufacturing of stainless steels, sub-micron sized oxide (i.e., MnSiO3 , SiO2 , and CrMn2O4) and non-oxide (i.e., sulfide, in particular MnS, and possibly carbides, phosphides and nitrides) precipitates form during solidification. But do they evolve during the subsequent solid-state thermal cycling (SSTC) until the end of the printing process? A recent study on subjecting thin-film lamellae extracted from an additively manufactured stainless steel to heating-cooling treatments inside a transmission electron microscope (TEM) confirmed that precipitate composition can indeed evolve during SSTC. However, that study could not provide any conclusive evidence on precipitate volume fraction, density, and size evolution. In this work, we have quantified these changes using a novel experimental procedure combining (i) micropillar extraction from an additively manufactured stainless steel, (ii) subjecting them to different SSTC (including annealing) inside a TEM, (iii) performing synchrotron transmission X-ray microscopy to identify precipitates, and (iv) using a machine learning model to segment precipitates and quantify precipitate volume fraction, density, and size. Comparing these quantities before and after each SSTC/annealing sequence reveals that new oxides nucleated during rapid SSTC with high maximum temperature. However, during slow SSTC with high maximum temperature and annealing, precipitates dissolve because of oxygen evaporation during SSTC inside the TEM. A new empirical relationship correlating precipitate sizes and cooling rates is proposed. It is in good agreement with data collected from conventional casting, directed energy deposition, and powder bed fusion processes