196 research outputs found

    Introducing the MiniPONS: A Short Multichannel Version of the Profile of Nonverbal Sensitivity (PONS)

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    Despite extensive research activity on the recognition of emotional expression, there are only few validated tests of individual differences in this competence (generally considered as part of nonverbal sensitivity and emotional intelligence). This paper reports the development of a short, multichannel, version (MiniPONS) of the established Profile of Nonverbal Sensitivity (PONS) test. The full test has been extensively validated in many different cultures, showing substantial correlations with a large range of outcome variables. The short multichannel version (64 items) described here correlates very highly with the full version and shows reasonable construct validity through significant correlations with other tests of emotion recognition ability. Based on these results, the role of nonverbal sensitivity as part of a latent trait of emotional competence is discussed and the MiniPONS is suggested as a convenient method to perform a rapid screening of this central socioemotional competenc

    Gesellschaftliche Integrität der Forschung: Wissenschaftsforschung Jahrbuch 2005

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    Gesellschaftliche Integrität von Forschung bezieht sich nach Hippokrates vor allem auf das Methodische bei der Problembearbeitung: ein forschender Arzt ist verpflichtet, sich nur solcher Methoden zu bedienen, die dem Patienten nutzen, auf keinen Fall aber schaden dürfen. In diesem Sinne wird auch in unserer Zeit auf Unangemessenheiten in der Art naturwissenschaftlicher Wissensproduktion hingewiesen. „Unangemessenheit“ ist dabei als relationaler Begriff zu verstehen. Vor jeder Wertung stellt sie zunächst nur ein Verhältnis zwischen Eigenschaften der Wissenschaft und Eigenschaften des makrosystemischen Kontextes dar. Ändern sich die Systeme, die zu den Umwelten der Wissenschaften gehören, dann können sich die Bedingungen und Bestimmungen gesellschaftlicher Integrität von Forschung ebenfalls verschieben. Dieses Problem stellt sich in analoger Weise für jedes andere System. Auch die Politik, die Ökonomie und gegebenfalls auch andere Systeme sind gezwungen, die Implikationen von Informationen aus der Wissenschaftsentwicklung für die Funktionsabläufe und Ziele des eigenen Systems zu überprüfen (eine Übersetzung der fremdsystemischen Information in den Eigencode des Systems anzufertigen) und gegebenenfalls zu handeln. Dabei gibt es nicht selten Friktionen. Nicht immer zeigt sich zum Beispiel die Politik offen für die Berücksichtigung der neuen Erkenntnisse. Es gibt Fälle, in denen sie sowohl die Gewinnung als auch die Ausnutzung neuer wissenschaftlicher Ansätze zu blockieren versucht – aus welchen Gründen auch immer. Für die Wissenschaftsforschung steht vor allem die gesellschaftliche Integrität der Forschung selbst zur Diskussion. Die Gesellschaft für Wissenschaftsforschung hat sich dieser Fragestellung angenommen und sie im Rahmen ihrer Jahrestagung im Wissenschaftszentrum Berlin für Sozialforschung am 18. März 2005 unter dem Thema „Die gesellschaftliche Integrität der Forschung“ analysiert und diskutiert. Dabei ist es gelungen, theoretische Überlegungen mit historischen und aktuellen Fakten zu verbinden. Die Ergebnisse dieser Tagung werden in diesem Jahrbuch der Gesellschaft für Wissenschaftsforschung dem interessierten Leser vorgestellt.Peer Reviewe

    Quantal Two-Centre Coulomb Problem treated by means of the Phase-Integral Method I. General Theory

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    The present paper concerns the derivation of phase-integral quantization conditions for the two-centre Coulomb problem under the assumption that the two Coulomb centres are fixed. With this restriction we treat the general two-centre Coulomb problem according to the phase-integral method, in which one uses an {\it a priori} unspecified {\it base function}. We consider base functions containing three unspecified parameters C,C~C, \tilde C and Λ\Lambda. When the absolute value of the magnetic quantum number mm is not too small, it is most appropriate to choose Λ=∣m∣≠0\Lambda=|m|\ne 0. When, on the other hand, ∣m∣|m| is sufficiently small, it is most appropriate to choose Λ=0\Lambda = 0. Arbitrary-order phase-integral quantization conditions are obtained for these choices of Λ\Lambda. The parameters CC and C~\tilde C are determined from the requirement that the results of the first and the third order of the phase-integral approximation coincide, which makes the first-order approximation as good as possible. In order to make the paper to some extent self-contained, a short review of the phase-integral method is given in the Appendix.Comment: 23 pages, RevTeX, 4 EPS figures, submitted to J. Math. Phy

    Social influences on formula intake via suckling in 7 to 14-week-old-infants

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    To investigate social influences on human suckling behavior, 25 healthy, full term, 7 to 14-week-old infants were each bottle-fed their own formula twice by their mother and once in each of four experimental conditions: (a) held, provided social interaction; (b) held, without interaction; (c) not held, provided interaction; (d) not held, without interaction. Volume intake (VI), Total Sucks, infant gaze direction, and time elapsed since the last feeding were determined. There were three major findings: (1) social interaction increased VI; (2) VI was linearly related to the time since the last feeding in held infants; (3) Total Sucks and VI were both highly correlated with privation length when infants did not look at the feeder and when fed by the mother. Thus, social influences exert strong immediate impacts on suckling. Accordingly, suckling functions to obtain both nutrition from and social information about the feeder. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 351–361, 2007.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55993/1/20221_ftp.pd

    Mouse Resource Browser--a database of mouse databases.

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    The laboratory mouse has become the organism of choice for discovering gene function and unravelling pathogenetic mechanisms of human diseases through the application of various functional genomic approaches. The resulting deluge of data has led to the deployment of numerous online resources and the concomitant need for formalized experimental descriptions, data standardization, database interoperability and integration, a need that has yet to be met. We present here the Mouse Resource Browser (MRB), a database of mouse databases that indexes 217 publicly available mouse resources under 22 categories and uses a standardised database description framework (the CASIMIR DDF) to provide information on their controlled vocabularies (ontologies and minimum information standards), and technical information on programmatic access and data availability. Focusing on interoperability and integration, MRB offers automatic generation of downloadable and re-distributable SOAP application-programming interfaces for resources that provide direct database access. MRB aims to provide useful information to both bench scientists, who can easily navigate and find all mouse related resources in one place, and bioinformaticians, who will be provided with interoperable resources containing data which can be mined and integrated. Database URL: http://bioit.fleming.gr/mrb

    Grape Seed Proanthocyanidins Inhibit the Invasiveness of Human HNSCC Cells by Targeting EGFR and Reversing the Epithelial-To-Mesenchymal Transition

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    Head and neck squamous cell carcinoma (HNSCC) is responsible for approximately 20,000 deaths per year in the United States. Most of the deaths are due to the metastases. To develop more effective strategies for the prevention of metastasis of HNSCC cells, we have determined the effect of grape seed proanthocyanidins (GSPs) on the invasive potential of HNSCC cell and the mechanisms underlying these effects using OSC19 cells as an in vitro model. Using cell invasion assays, we established that treatment of the OSC19 cells with GSPs resulted in a dose-dependent inhibition of cell invasion. EGFR is over-expressed in 90% of HNSCCs and the EGFR inhibitors, erlotinib and gefitinib, are being explored as therapies for this disease. We found that GSPs treatment reduced the levels of expression of EGFR in the OSC19 cells as well as reducing the activation of NF-κB/p65, a downstream target of EGFR, and the expression of NF-κB-responsive proteins. GSPs treatment also reduced the activity of ERK1/2, an upstream regulator of NF-κB and treatment of the cells with caffeic acid phenethyl ester, an inhibitor of NF-κB, inhibited cell invasion. Overexpression of EGFR and high NF-κB activity play a key role in the epithelial-to-mesenchymal transition, which is of critical importance in the processes underlying metastasis, and we found treatment with GSPs enhanced the levels of epithelial (E-cadherin, cytokeratins and desmoglein-2) and reduced the levels of mesenchymal (vimentin, fibronectin, N-cadherin and Slug) biomarkers in the OSC19 cells. These results indicate that GSPs have the ability to inhibit HNSCC cell invasion, and do so by targeting the expression of EGFR and activation of NF-κB as well as inhibiting the epithelial-to-mesenchymal transition

    Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

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    This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
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