5,642 research outputs found

    Math biology and quantum chaos highlight sixth annual meeting of SIAM's UKIE section

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    The sixth annual meeting of the UKIE Section of SIAM, held at Leeds University on January 11, provided a taste of the diversity of industrial and applied mathematics activity in the UK and the Republic of Ireland. Organised by the section officers---David Parker (president), Ivan Graham (vice-president), and Peter Jimack (secretary/treasurer)-the meeting brought together more than 50 people to hear talks on subjects ranging from mathematical biology to quantum chaos

    Genetics Crime and Justice

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    This review is unashamedly from the perspective of English law because busy United Kingdom criminal law solicitors and barristers mostly wish to know what the law states, which case is a precedent case and whether the author has provided up-to-date legal information. This is because legal practitioners deal with real and urgent cases. The English Income Tax Act gained Royal Assent in 1799 the first government attempt to stop early tax avoidance. Later, tax avoidance schemes (which in English Law were deemed a legitimate method of minimising one payment of taxation) became de rigueur all over the world and often involved creation of Deeds of Covenant and Trusts, notably Discretionary Trusts under civil law. Manā€™s ingenuity knows no bounds and this applies to manā€™s characteristic of criminality as it does to scholarship, enterprise and innovation. Despite protestations by some countries police agencies, contrary to the rise of crime, the fact is that that crime is increasing exponentially worldwide, but the number of people committing crime is not increasing because many crimes are repeated crimes committed by persons with habitual criminal behaviour, ie hard-core criminals

    Introduction: The difference that makes a difference

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    This article introduces TripleCā€™s Special Issue on The Difference That Makes a Difference, containing papers arising from a workshop of the same name that ran in Milton Keynes in September 2011. The background to the workshop is explained, workshop sessions are summarised, and the content of the papers introduced. Finally, some provisional outcomes from the workshop and the Special Issue are described

    Systems Thinkers

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    Systems Thinkers presents a biographical history of the field of systems thinking, by examining the life and work of thirty of its major thinkers. It discusses each thinker's key contributions, the way this contribution was expressed in practice and the relationship between their life and ideas. This discussion is supported by an extract from the thinker's own writing, to give a flavour of their work and to give readers a sense of which thinkers are most relevant to their own interests. \ud Systems thinking is necessarily interdisciplinary, so that the thinkers selected come from a wide range of areas - biology, management, physiology, anthropology, chemistry, public policy, sociology and environmental studies among others. Some are core innovators in systems ideas; some have been primarily practitioners who also advanced and popularised systems ideas; others are well-known figures who drew heavily upon systems thinking although it was not their primary discipline. A significant aim of the book is to broaden and deepen the reader's interest in systems writers, providing an appetising "taster" for each of the 30 thinkers, so that the reader is encouraged to go on to study the published works of the thinkers themselves

    Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris

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    The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection

    Local stability and a renormalized Newton Method for equilibrium liquid crystal director modeling

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    We consider the nonlinear systems of equations that result from discretizations of a prototype variational model for the equilibrium director field characterizing the orientational properties of a liquid crystal material. In the presence of pointwise unit-vector constraints and coupled electric fields, the numerical solution of such equations by Lagrange-Newton methods leads to problems with a double saddle-point form, for which we have previously proposed a preconditioned nullspace method as an effective solver [A. Ramage and E. C. Gartland, Jr., submitted]. The characterization of local stability of solutions is complicated by the double saddle-point structure, and here we develop efficiently computable criteria in terms of minimum eigenvalues of certain projected Schur complements. We also propose a modified outer iteration (ā€œRenormalized Newton Methodā€) in which the orientation variables are normalized onto the constraint manifold at each iterative step. This scheme takes advantage of the special structure of these problems, and we prove that it is locally quadratically convergent. The Renormalized Newton Method bears some resemblance to the Truncated Newton Method of computational micromagnetics, and we compare and contrast the two
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