Effect of Scorbic acid on Hyperlipidemia

هیپرلیپیدمی یکی از مهم ترین ریسک فاکتورهای آترواسکروزیس می باشد که عامل مهمی در بروز بیماریهای قلبی و سکته مغزی است. اگر چه داروهای مفیدی برای کاهش چربی های خون وارد بازار شده ولی تلاش برای یافتن مواد موثرتر و کم عارضه تر همچنان ادامه دارد. با توجه به گزارشات پراکنده مبنی بر احتمال تـأثیر مثبت مصرف ویتامین C بر کاهش چـربی های خون در این تحـقیق تاثیر این ویتامین بر تری گلیـسرید، کلستـرول، لیپو پروتئین با چـگالی پائین (LDL) و لیپو پروتئین با چگالی بالا (HDL)، در بیماران مصرف کننده لیپیدمی ، مورد بررسی قرار گرفت. در یک کارآزمایی بالینی دو سوکور دو گروه 31 نفره از بیماران مبتلا به هیپرلیپیدمی مصرف کننده لواستاتین انتخاب و پس از انجام آزمایشات مربوط به چربی خون، به گروه مورد روزانه 1000 میلی گرم ویتامین C و به گروه شاهد پلاسبو اضافه شد. پس از 10 هفته مجدداً خون بیماران مورد آزمایش قرار گرفت. نتایج مطالعه نشان داد در هیچ یک از فاکتورهای تری گلیسرید، کلسترول و LDL از نظر آماری تغییر حاصل نشده، ولی میزان HDL بیماران تحت درمان با ویتامین C در مقایسه با گروهی که پلاسبو دریافت کرده بودند افزایش پیدا کرده بود (05/0

Medicinal plants for renal injury prevention.

It has been estimated that about 20% of men and 25% of women between the ages of 65 and 74 have some degrees of chronic kidney. This complication is attributed to oxidative stress. Oxidative stress is an important factor contributing to kidney damage by increasing production of oxidants, particularly insufficiency of endogenous antioxidant defense system. Medicinal plants antioxidants are able to ameliorate oxidative induced kidney damage by reduction of lipid peroxidation and enhancement of scavenging ability of antioxidant defense system. Supplementation of medicinal plants antioxidants might be considered important remedies to abrogate pathology of oxidative stress induced kidney damage, however, single antioxidants do not act the same and might not be beneficial

Plants antioxidants: From laboratory to clinic

Implication for health policy/practice/research/medical education: Eating whole vegetables, fruits and grains, which all are rich in antioxidants, provides protection against most of oxidative stress induced diseases, however, this does not mean that antioxidants will prevent or fix the problem, especially not when they are taken out of their natural context. It should be noted that although the results of the studies are inconclusive, but most of the studies conducted till now have had limitations due to their relatively short duration and conducting on patients with existing diseases. © 2013, Society of Diabetic Nephropathy Prevention. All rights reserved

Serum lipoprotein (a) and atherosclerotic changes in hemodialysis patients.

INTRODUCTION Lipoprotein (a) [Lp(a)] is considered as a risk factor for coronary atherosclerotic disorder and an increase in plasma Lp(a) concentration is usually seen in patients with kidney failure. OBJECTIVES We aimed in this study to evaluate the impact of plasma Lp(a) level on early changes of atherosclerotic vessels in stable hemodialysis (HD) patients. PATIENTS AND METHODS In this clinical study 61 patients (50 non-diabetic (F=20 M=30) and 11 diabetic HD patients), receiving maintenance hemodialysis were included and serum Lp(a) was measured. B-mode ultrasonography of carotid intima-media thickness (cIMT) was also determined. RESULTS The mean ±SD of patients Lp(a) was 58.5±19 mg/dL. The mean ±SD of diabetic patients' Lp(a) was 62±12mg/dL and for nondiabetic ones was 57.7± 20mg/dL. In this study the thickening of Intima-media complex in diabetic group was more than non-diabetics, and no significant difference was found of Lp(a) between diabetic and non diabetic HD patients. There was a significant positive association between serum Lp(a) and cIMT. CONCLUSION Accelerated atherosclerosis seen in diabetic hemodialysis patients. Lp(a) might have an important role in progression of atherosclerosis to accelerate progressive atherosclerosis in these patients

Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice

Background: Crocus sativus, known as saffron crocus, is best known for the spice saffron. Saffron use spans more than 3500 years, however, its toxicity on neonates during lactation has not yet evaluated. Objectives: This study was aimed to examine the acute toxicity of saffron on adult mice and its nephrotoxicity and hepatotoxicity on neonates of lactating mothers that used saffron during lactation. Materials and Methods: In this experimental study, following acute toxicity evaluation, 32 pregnant mice were randomly designated into four equal groups. Following delivery, the mothers of groups 1 to 4 were administered orally (by gavage) normal saline (control group), 500, 1000 or 2000 mg/kg/day of saffron for three weeks, respectively. The newborns’ kidney and liver parameters were assessed at the end of the study for possible nephrotoxicity and hepatotoxicity evaluation. The kidney and liver tissue samples of newborns were histopathologically studied after staining with Hematoxylin & Eosin. Data were analyzed using ANOVA and Scheffe’s tests Results: The LD50 value of saffron was calculated to be 4120±556 mg/kg in mice. To evaluate lactating toxicity, saffron was administered orally to the mothers once daily for 21 days, after delivery, during lactating period. Saffron increased serum urea nitrogen (p< 0.05). Histological studies indicated that saffron did not have any toxic effect on liver, however, histopathology changes were seen in the kidney of neonates. Conclusions: From the results of present study, it might be concluded that saffron is a nearly safe spice, however, nursing mothers should avoid high doses of this spice. © 2014, Society of Diabetic Nephropathy Prevention. All rights reserved