59 research outputs found


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    This thesis compares Bar-Gera's Method and Aashtiani's Method for solving the static traffic assignment problem with fixed demand. Specifically, it compares the computational time spent by their corresponding algorithms in thirteen networks based on real cities. It also verifies whether the assumptions made by both methods and the data used allowed such a comparison. To implement Aashtiani's algorithm, a computer code was appropriately designed. To implement Bar-Gera's algorithm, a non-open source application was used. Numerical results showed mixed results but still showed the following trends: (1) Aashtiani's algorithm seems to be faster when solving complex networks, (2) Bar-Gera's algorithm is almost always faster for very high levels of accuracy while Aashtiani's algorithm is faster for lower levels of accuracy, and (3) Bar-Gera's algorithm almost always increases its speed consistently as more accuracy is demanded. Numerical results also showed that for small networks (specifically, when the number of arcs times the number of links is less than 1.0E+7), both algorithms spent practically no more than one second, rending these networks not recommendable for carrying out future comparisons. As expected, Bar-Gera's method required less memory. This thesis also presents a unified terminology for both methods and adapted Aashtiani's formulation to this specific problem

    Pertinencia jur√≠dica del convenio Interadministrativo No. 16 de 2009 celebrado entre el municipio de Carmen de Chucur√≠ y la empresa de acueducto, alcantarillado y aseo ‚ÄďACUASAN

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    Este trabajo de investigaci√≥n busca analizar la pertinencia del convenio interadministrativo No 16 del 13 de noviembre de 2009 celebrado entre el municipio de Carmen de Chucuri y la empresa de acueducto, alcantarillado y aseo ‚ÄďACUASAN-: un an√°lisis jur√≠dico-constitucional a partir de las reglas de la contrataci√≥n directa y de los principios de econom√≠a, transparencia y el deber de selecci√≥n objetiva. Para ello, se precisar√° el marco legal, jurisprudencial y te√≥rico de la contrataci√≥n directa, enfatizando en la modalidad de Convenio Interadministrativo. A partir de lo anterior, se describir√° el marco normativo, jurisprudencial y te√≥rico de los principios de la contrataci√≥n estatal, de econom√≠a, transparencia y deber de selecci√≥n objetiva. Por √ļltimo, se har√° un parang√≥n entre el sentido de los principios mencionados y el referido convenio interadministrativo, esto en aras de determinar su congruencia, concordancia y pertinencia jur√≠dico-constitucional.Universidad Libre Seccional Socorro -- Facultad de derecho, ciencias pol√≠ticas y sociales -- Maestr√≠a en derecho administrativoThis research work seeks to establish the relevance of inter-administrative agreement No. 16 of November 13, 2009, between the municipality of Carmen de Chucuri and the aqueduct, sewage and sanitation company -ACUASAN-: a legal-constitutional analysis based on the rules of direct contracting and the principles of economy and transparency and the duty of objective selection. For this, the legal, jurisprudential and theoretical framework of direct contracting will be specified, emphasizing the Inter-administrative Agreement modality. Based on the above, the regulatory, jurisprudential and theoretical framework of the principles of state contracting of economy, transparency and duty of objective selection will be described. Finally, a comparison will be made between the meaning of the principles of state contracting and the aforementioned inter-administrative agreement, in order to determine its consistency, concordance and legal-constitutional relevance

    Density Models and Safety Analysis for Rural Unsignalised Restricted Crossing U-turn Intersections

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    AbstractThe first objective of this study was to provide designers with a model that would help them assess the suitability of implementing an unsignalized restricted crossing U-turn (RCUT) based on the traffic volume arriving to a given rural intersection. Specifically, this study identified the zones that were most susceptible to bottlenecks and provided regression models that calculate the traffic density as a function of the traffic volume. In addition, the second objective of this study was to look at how the number of traffic conflicts varied with the traffic volume. Two geometric design cases were studied: four-lane and six-lane arterials using 1000 foot long (305 m long) weaving sections. VISSIM traffic simulations were used to identify the critical zones, and calculate the traffic density for different traffic flows. Volumes and densities allowed the development of regression models. Two critical zones were identified: where vehicles coming from the minor road merge to enter the U-turn and where vehicles exiting the U-turn merge to the multilane arterial. Also, based on the classification given by this study to the traffic volumes, a sensitivity analysis determined which of them had the greatest impact on the level of service. For the number of traffic conflicts from simulation, the Surrogate Safety Analysis Model was applied to measure them. This study found that at certain traffic volumes, traffic conflicts rise sharply. © 2011 Published by Elsevier Ltd

    Inducible Slc7a7 Knockout Mouse Model Recapitulates Lysinuric Protein Intolerance Disease

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    Lysinuric protein intolerance (LPI) is a rare autosomal disease caused by defective cationic amino acid (CAA) transport due to mutations in SLC7A7, which encodes for the y+LAT1 transporter. LPI patients suffer from a wide variety of symptoms, which range from failure to thrive, hyperammonemia, and nephropathy to pulmonar alveolar proteinosis (PAP), a potentially life-threatening complication. Hyperammonemia is currently prevented by citrulline supplementation. However, the full impact of this treatment is not completely understood. In contrast, there is no defined therapy for the multiple reported complications of LPI, including PAP, for which bronchoalveolar lavages do not prevent progression of the disease. The lack of a viable LPI model prompted us to generate a tamoxifen-inducible Slc7a7 knockout mouse (Slc7a7-/-). The Slc7a7-/- model resembles the human LPI phenotype, including malabsorption and impaired reabsorption of CAA, hypoargininemia and hyperammonemia. Interestingly, the Slc7a7-/- mice also develops PAP and neurological impairment. We observed that citrulline treatment improves the metabolic derangement and survival. On the basis of our findings, the Slc7a7-/- model emerges as a promising tool to further study the complexity of LPI, including its immune-like complications, and to design evidence-based therapies to halt its progression

    Relationship between perceived stress and sleep quality in night-shift and rotating nurses

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    Objective: To determine if there is a relationship between perceived stress and sleep quality in nurses in the night and rotating shifts of the social enterprise of the State Hospital San Rafael of Facatativ√°. Methodology: cross-sectional study with a correlational scope where the perceived stress was assessed through the Perceived Stress Scale, Version 14, and sleep quality using the Pittsburg Sleep Quality Index, Colombian Version, in a sample of 98 nurses who met the inclusion criteria. Results: a prevalence of 72.45% of perceived stress and 79.59% of poor sleep quality were perceived; there was a low correlation between these two variables (r= 0.258; p=0.010). It can be ensured with 95% of confidence that when one variable increases, the other one does the same; this means that higher stress level in the perceived stress scale implies a higher score in the Pittsburgh Sleep Quality Index, which suggests that stress level is a factor that has direct proportionality with sleep; so, higher stress level is equal to worse sleep quality. Conclusions: It is concluded that there is a relationship between perceived stress and sleep quality, showing that, the greater the stress in the nurses, the worse the quality of sleep, and conversely, the worse the quality of sleep, the greater the stress.Introduction: Stress and poor quality of sleep are companions to the workday and life in general, stress being a modifier of the quantity and quality of sleep and, in turn, the quality of sleep modulating levels of stress. Objective: To determine the relationship between perceived stress and quality of sleep in nurses in the night and rotating shifts of the E.S.E. San Rafael de Facatativ√° Hospital. Methodology: Study with quantitative approach, cross-sectional and correlational scope where the perceived stress was assessed through the Perceived Stress Scale, Version 14 (EEP-14) and sleep quality using the Pittsburg Sleep Quality Index, Version Colombian (ICSP-VC) in a sample of 98 nurses who met the inclusion criteria. Results: A prevalence of 72.45% of perceived stress and 79.59% of poor sleep quality was evidenced. Regarding the relationship between variables, it was found that they have a significant correlation (r = 0.258; p = 0.010) and can be assured with 95% confidence, that while one variable increases, the other also does, that is, The more score on the perceived stress scale which indicates higher stress, the higher the Pittsburgh sleep quality index, indicating worse quality. Conclusions: It is concluded that the perceived stress and the quality of sleep are factors that have a bidirectional relationship, pointing out that, the greater the stress in the nurses, the worse the quality of sleep, as well as the worse the quality of sleep, the greater the stress

    Efecto de la radiación ultravioleta B sobre mohos patógenos de setas cultivadas

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    Es conocido el efecto fungicida de la radiaci√≥n UV-C (100-280nm de longitud de onda), pero suaplicabilidad para el control de mohos pat√≥genos de setas cultivadas resulta condicionada porsu efecto sobre el hu√©sped y por los riesgos inherentes a su manipulaci√≥n. Como alternativa, seha estudiado el efecto de la radiaci√≥n UV-B (280-315nm) sobre los principales mohos pat√≥genosde los cultivos de setas causantes de lesiones conocidas como telara√Īa o pelo (Cladobotryummycophilum), mole seca (Lecanicillium fungicola), moho verde (Trichoderma aggressivum) ymole h√ļmeda (Mycogone perniciosa). Los mohos estudiados se sembraron (por triplicado) sobreplacas de agar Czapek que se irradiaron con l√°mparas de radiaci√≥n UV-B (300nm) situadas a 25cmde altura, obteniendo una irradiancia de 16 Wm-2. Se aplicaron diferentes tiempos de exposici√≥n(0, 1, 3, 6, 12 y 24 horas) sobre dos series de placas. Una de las series se protegi√≥ de la radiaci√≥nmediante filtros de radiaci√≥n UV y actu√≥ de control. Tras la exposici√≥n, las placas fueron incubadasa 20¬ļC en oscuridad, valorando el grado de desarrollo de los mohos a lo largo de dos semanas. Laradiaci√≥n UV-B caus√≥ un claro efecto inhibidor, proporcional a la dosis de irradiaci√≥n recibida, enel desarrollo de los mohos estudiados. Aunque en ning√ļn caso se observ√≥ la muerte del moho, elretraso en el crecimiento respecto a su control lleg√≥ a alcanzar los 8-12 d√≠as seg√ļn especie. Paracomprobar si la radiaci√≥n aplicada afectaba al desarrollo de la seta cultivada, se inocularon placasde Agar Compost con Agaricus bisporus y se expusieron a radiaci√≥n UV-B (0, 6, 12 y 24 h). No seobservaron diferencias entre el desarrollo de champi√Ī√≥n en las placas irradiadas y su control. Esteresultado permitir√≠a utilizar la radiaci√≥n UV-B en el control de mohos micopat√≥genos sin afectar alas setas cultivadas

    Análisis de los factores satisfacción, apropiación y pertenencia, asociados al desarrollo de la identidad en las trabajadoras de la empresa EFICACIA S.A, línea lice

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    Este artículo tiene como objetivo analizar los factores que se encuentran asociados a la Identidad como satisfacción, apropiación y pertenencia de las trabajadoras de EFICACIA S.A, línea Lice. La metodología utilizada en la investigación es de naturaleza descriptiva e interpretativa, con un enfoque cualitativo y cuantitativo, permitiendo conocer la percepción que tienen las trabajadoras de la línea Lice sobre la organización

    Oral insulin-mimetic compounds that act independently of insulin

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    The hallmarks of insulin action are the stimulation and suppression of anabolic and catabolic responses, respectively. These responses are orchestrated by the insulin pathway and are initiated by the binding of insulin to the insulin receptor, which leads to activation of the receptor's intrinsic tyrosine kinase. Severe defects in the insulin pathway, such as in types A and B and advanced type 1 and 2 diabetes lead to severe insulin resistance, resulting in a partial or complete absence of response to exogenous insulin and other known classes of antidiabetes therapies. We have characterized a novel class of arylalkylamine vanadium salts that exert potent insulin-mimetic effects downstream of the insulin receptor in adipocytes. These compounds trigger insulin signaling, which is characterized by rapid activation of insulin receptor substrate-1, Akt, and glycogen synthase kinase-3 independent of insulin receptor phosphorylation. Administration of these compounds to animal models of diabetes lowered glycemia and normalized the plasma lipid profile. Arylalkylamine vanadium compounds also showed antidiabetic effects in severely diabetic rats with undetectable circulating insulin. These results demonstrate the feasibility of insulin-like regulation in the complete absence of insulin and downstream of the insulin receptor. This represents a novel therapeutic approach for diabetic patients with severe insulin resistance

    Global, regional, and national estimates of tuberculosis incidence and case detection among incarcerated individuals from 2000 to 2019: a systematic analysis.

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    People who are incarcerated are at high risk of developing tuberculosis. We aimed to estimate the annual global, regional, and national incidence of tuberculosis among incarcerated populations from 2000 to 2019. We collected and aggregated data for tuberculosis incidence and prevalence estimates among incarcerated individuals in published and unpublished literature, annual tuberculosis notifications among incarcerated individuals at the country level, and the annual number of incarcerated individuals at the country level. We developed a joint hierarchical Bayesian meta-regression framework to simultaneously model tuberculosis incidence, notifications, and prevalence from 2000 to 2019. Using this model, we estimated trends in absolute tuberculosis incidence and notifications, the incidence and notification rates, and the case detection ratio by year, country, region, and globally. In 2019, we estimated a total of 125‚Äą105 (95% credible interval [CrI] 93‚Äą736-165‚Äą318) incident tuberculosis cases among incarcerated individuals globally. The estimated incidence rate per 100‚Äą000 person-years overall was 1148 (95% CrI 860-1517) but varied greatly by WHO region, from 793 (95% CrI 430-1342) in the Eastern Mediterranean region to 2242 (1515-3216) in the African region. Global incidence per 100‚Äą000 person-years between 2000 and 2012 among incarcerated individuals decreased from 1884 (95% CrI 1394-2616) to 1205 (910-1615); however, from 2013 onwards, tuberculosis incidence per 100‚Äą000 person-years was stable, from 1183 (95% CrI 876-1596) in 2013 to 1148 (860-1517) in 2019. In 2019, the global case detection ratio was estimated to be 53% (95% CrI 42-64), the lowest over the study period. Our estimates suggest a high tuberculosis incidence rate among incarcerated individuals globally with large gaps in tuberculosis case detection. Tuberculosis in incarcerated populations must be addressed with interventions specifically tailored to improve diagnoses and prevent transmission as a part of the broader global tuberculosis control effort. National Institutes of Health. [Abstract copyright: This is an Open Access article published under the CC BY 3.0 IGO license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.
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