1,214 research outputs found

    Fake-news-free evidence-based communication for proper vein-lymphatic disease management

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    Published scientific evidence demonstrate the current spread of healthcare misinformation in the most popular social networks and unofficial communication channels. Up to 40% of the medical websites were identified reporting inappropriate information, moreover being shared more than 450,000 times in a 5-year-time frame. The phenomenon is particularly spread in infective diseases medicine, oncology and cardiovascular medicine. The present document is the result of a scientific and educational endeavor by a worldwide group of top experts who selected and analyzed the major issues and related evidence-based facts on vein and lymphatic management. A section of this work is entirely dedicated to the patients and therefore written in layman terms, with the aim of improving public vein-lymphatic awareness. The part dedicated to the medical professionals includes a revision of the current literature, summing up the statements that are fully evidence-based in venous and lymphatic disease management, and suggesting future lines of research to fulfill the still unmet needs. The document has been written following an intense digital interaction among dedicated working groups, leading to an institutional project presentation during the Universal Expo in Dubai, in the occasion of the v-WINter 2022 meeting

    Fake-news-free evidence-based communication for proper vein-lymphatic disease management

    No full text
    Published scientific evidence demonstrate the current spread of healthcare misinformation in the most popular social networks and unofficial communication channels. Up to 40% of the medical websites were identified reporting inappropriate information, moreover being shared more than 450,000 times in a 5-year-time frame. The phenomenon is particularly spread in infective diseases medicine, oncology and cardiovascular medicine. The present document is the result of a scientific and educational endeavor by a worldwide group of top experts who selected and analyzed the major issues and related evidence-based facts on vein and lymphatic management. A section of this work is entirely dedicated to the patients and therefore written in layman terms, with the aim of improving public vein-lymphatic awareness. The part dedicated to the medical professionals includes a revision of the current literature, summing up the statements that are fully evidence-based in venous and lymphatic disease management, and suggesting future lines of research to fulfill the still unmet needs. The document has been written following an intense digital interaction among dedicated working groups, leading to an institutional project presentation during the Universal Expo in Dubai, in the occasion of the v-WINter 2022 meeting.</p

    Is Weak Supplementation analytic?

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    Mereological principles are often controversial; perhaps the most stark contrast is between those who claim that Weak Supplementation is analytic—constitutive of our notion of proper parthood—and those who argue that the principle is simply false, and subject to many counterexamples. The aim of this paper is to diagnose the source of this dispute. I’ll suggest that the dispute has arisen by participants failing to be sensitive to two different conceptions of proper parthood: the outstripping conception and the non-identity conception. I’ll argue that the outstripping conception (together with a specific set of definitions for other mereological notions), can deliver the analyticity of Weak Supplementation on at least one sense of ‘analyticity’. I’ll also suggest that the non-identity conception cannot do so independently of considerations to do with mereological extensionality

    A plant cyclin B2 is degraded early in mitosis and its ectopic expression shortens G2-phase and alleviates the DNA-damage checkpoint

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    Mitotic progression is timely regulated by the accumulation and degradation of A- and B-type cyclins. In plants, there are three classes of A-, and two classes of B-type cyclins, but their specific roles are not known. We have generated transgenic tobacco plants in which the ectopic expression of a plant cyclin B2 gene is under the control of a tetracycline-inducible promoter. We show that the induction of cyclin B2 expression in cultured cells during G2 phase accelerates the entry into mitosis and allows cells to override the replication checkpoint induced by hydroxyurea in the simultaneous presence of caffeine or okadaic acid, drugs that are known to alleviate checkpoint control. These results indicate that in plants, a B2-type cyclin is a rate-limiting regulator for the entry into mitosis and a cyclin B2-CDK complex might be a target for checkpoint control pathways. The cyclin B2 localization and the timing of its degradation during mitosis corroborate these conclusions: cyclin B2 protein is confined to the nucleus and during mitosis it is only present during a short time window until mid prophase, but it is effectively degraded from this timepoint onwards. Although cyclin B2 is not present in cells arrested by the spindle checkpoint in metaphase, cyclin B1 is accumulating in these cells. Ectopic expression of cyclin B2 in developing plants interferes with differentiation events and specifically blocks root regeneration, indicating the importance of control mechanisms at the G2- to M-phase transition during plant developmental processes.M.W. was supported by a PhD fellowship from the Austrian Academy of Sciences. This work was supported by an Austrian Förderung der Wissenschaftlichen Forschung grant to E.H.-B.; by European Union Framework V project ECCO Grant QLRT-1999-00454 to E.H.-B., L.B. and P.B.; by a Biotechnology and Biological Science Research Council grant (111/P133340) to L.B.; by grant LN00A081 from the Czech Ministry of Education; by a collaborative Wellcome Trust grant to P.B. and L.B.; and by a Spanish Ministerio de Ciencia y Tecnologia grant (BMC2001-2195) to C.T. Moreover, we thank Gireg Weingartner for his patience and Giovanna Vinti, among others, for taking care of him

    Cruise Event Logs from 15 vessels for 116 U.S. GLOBEC cruises from 1997-2004 in the Northeast Pacific and Gulf of Alaska areas (NEP program)

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    Dataset: eventlogsCruise Event Logs from 15 vessels for 116 U.S. GLOBEC cruises from 1997-2004 in the Northeast Pacific and Gulf of Alaska areas For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/2341NSF Division of Ocean Sciences (NSF OCE) OCE-0000733, NSF Division of Ocean Sciences (NSF OCE) OCE-9732386, National Oceanic and Atmospheric Administration (NOAA) NA67RJ0151 (NEP), National Oceanic and Atmospheric Administration (NOAA) NA86OP0589 (NEP

    Biomass burning aerosols in most climate models are too absorbing

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    Uncertainty in the representation of biomass burning (BB) aerosol composition and optical properties in climate models contributes to a range in modeled aerosol effects on incoming solar radiation. Depending on the model, the top-of-the-atmosphere BB aerosol effect can range from cooling to warming. By relating aerosol absorption relative to extinction and carbonaceous aerosol composition from observational datasets to nine state-of-the-art Earth System Models/Chemical Transport Models,we identify varying degrees of overestimation in BB aerosol absorptivity by these models. Modifications to BB aerosol refractive index, size, and mixing state improve the Community Atmosphere Model version 5 (CAM5) agreement with observations, leading to a global change in BB direct radiative effect of -0.07 W m-2,and regional changes of -2 W m-2(Africa) and -0.5 W m-2(South America/Temperate). Our findings suggest that current modeled BB contributes less to warming than previously thought, largely due to treatments of aerosol mixing state

    Vertical distribution of aerosol particles and NOx close to a motorway, Atmos

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    Abstract In May 2001, the large-scale field project BAB II was performed at the highly frequented motorway BAB (Bundesautobahn) A656 with two traffic lanes in each direction between the German cities Heidelberg and Mannheim. Extensive measurements of air pollutants were carried out on both sides of the motorway. In a distance of 60 m (north side) and 84 m (south side) to the traffic lanes, two 52-m-high towers were installed, at which electrically powered elevators were fixed. In these elevators, two NO x analysers, an Electrical Low Pressure Impactor (ELPI; measurement of the particle number size distribution in the diameter range D between 30 nm and 10 mm) and a Diffusion Charger (DC; measuring the particle surface area concentration), were operated to record continuous vertical profiles from 5 to 50 m above the earth&apos;s surface. On the upwind side, particle number and surface area concentration as well as NO x values were constant over the entire height profile. On the downwind side, increased concentrations appeared in the near-ground range: in the forenoon, a monotonous decrease in pollutant concentrations with increasing height was found, while around noon the concentration maximum of the particles was slightly shifted to 10 m above ground. This height dependence was found for two different size ranges, i.e., for particles with Do300 nm (consisting of soot particles and nucleation mode particles formed by condensation as a result of cooling of the exhaust gas after emission), and for coarse particles (D41 mm; abrasion and resuspension products). In the size range between 300 and 700 nm, no height dependence was found, corroborating the fact that motor traffic emits only few particles in this size range. On the downwind side of the motorway, only background concentrations were measured above 25 m. The results of the profile measurements were confirmed by stationary measurements of particle size distributions with Scanning Mobility Particle Sizers (SMPS) at various heights. A good correlation between particle surface area and NO x concentration was observed. Vehicle emission factors were determined for the particle surface area, number and volume of several size ranges.

    Older people and creativity: What can a social pedagogical perspective add to this work?

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    While for some older people longevity is a blessing, for others it is a curse. This article draws on the author’s experience of working through the National Lottery Fund’s Ageing Better programme with groups of older people in Leicester, many of whom are marginalised in terms both of society and under-represented in research. Four psychosocial challenges are identified from this experience: handling change; chronic loneliness; meaninglessness; and loss of a social role. The article explores the significance of creativity whether linked to the participatory arts or creative thinking and problem solving in addressing these challenges. It acknowledges the value of the participatory arts but highlights problems of accessibility and sustainability. The article explores briefly the concept of ‘everyday creativity’ and touches on the underexplored areas of how creativity can link to freeing up some rigidities in mindset and opening older people up to new possibilities. Finally, it examines the principles and practices of social pedagogy. Despite there being very few examples of practice with older people in the UK named as social pedagogy, it is suggested that the perspective is highly relevant to this area of work. Not only do the values and skills match what is needed, but adopting a social pedagogical perspective across the sector might enhance the self-confidence of staff and volunteers, the quality of the work, and provide a much-needed common language. Psychosocial knowledge and skills could, with benefit, be integrated
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