12 research outputs found

    Asia Pacific Society of Human Genetics (APSHG) from conception to 2019: 13 years of collaboration to tackle congenital malformation and genetic disorders in Asia

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    Putting together the reports in this issue that come from a representation of the different countries in Asia presents an opportunity to share the unique story of the Asia Pacific Society of Human Genetics (APSHG), which has provided the authors of many of these articles. This paper, authored by the Past Presidents of the Society, shares glimpses of how medical genetics activities were first organized in the Asia Pacific region and provides interesting corollaries on how under-developed and developing countries in this part of the world had developed a unique network for exchange and sharing of expertise and resources. Although APSHG was formally registered as a Society in Singapore in 2006, the Society has its origins as far back as in the 1990s with members from different countries meeting informally, exchanging ideas, and collaborating. This treatise documents the story of the experiences of the Society and hopes it will provide inspiration on how members of a genetics community can foster and build a thriving environment to promote this field. © 2019 Wiley Periodicals, Inc

    Health utility weight of IEM patients.

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    <p>PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency</p><p>Health utility weight of IEM patients.</p

    Means and standard error (SE) of cost parameters presented in 2013 Thai Baht.

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    <p><sup>a</sup>Calculated at patient weight 1 kilogram.</p><p>NSCO = Neonatal Screening Operation Centre; PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency</p><p>1 I$ = 17.79 THB.</p

    Acceptability curve.

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    <p>The graph shows the probabilities of each strategy being cost-effective at a given ceiling ratio. The dashed lines represent the willingness to pay thresholds for the adoption of health interventions in Thailand.</p

    Mean and standard error (SE) of transitional probabilities used in the model.

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    <p><sup>a</sup> See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134782#pone.0134782.s001" target="_blank">S1 Table</a> for death from other causes.</p><p>PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency; RR = Relative risk of early-diagnosed patients compared with clinical diagnosed patients</p><p>Mean and standard error (SE) of transitional probabilities used in the model.</p

    Markov model.

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    <p>Health states transition of selected IEM. (A) represents PKU, IVA, MSUD and MCD; (B) represents MMA; and (C) represents PA. PKU = phenylketonuria; IVA = isovaleric acidemia; MMA = methylmalonic acidemia; PA = propionic acidemia; MSUD = maple syrup urine disease; MCD = multiple carboxylase deficiency.</p

    One-way sensitivity analysis.

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    <p>Tornado graph showing results of one-way sensitivity analysis derived from probabilistic method. These figures indicating parameters which have the largest effect on incremental cost effectiveness ratio or ICER (THB per QALY gained) when they are varied individually. IPD = cost of inpatient care; OPD = cost of outpatient care.</p
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