78 research outputs found

    Project of playul and automatized assessment of motor function in patients with NMD: MFM-Digital study

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    International audienceThe Motor Function Measure (MFM) is a validated and sensitive tool composed of 32 items, applicable to ambulant and non ambulant patients with neuromuscular disorders (NMD). It is currently used as outcome measure in clinical studies.By using digital technologies, we want to create an automatized MFM assessment. The objectives are to improve the MFM reliability and its acceptability by including the assessment in a serious game.Feasibility studies assessing the relevance of digital systems to capture postures and motions during a MFM test have shown that on 32 items of the MFM, 14 could be captured by the Kinect and 3 by a digital tablet. Here we present studies to the conception of the assessment with digital tools

    Data from: Changes in the chlorophyll content of grape leaves could provide a physiological index for responses and adaptation to UV-C radiation

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    Stilbenes are a group of phytoalexins that play an important role in grapevine (Vitis) basal immunity and can be induced by biotic and abiotic stresses. The levels of chlorophylls, the main pigments in plant cells, can also indicate the tolerance of plants to various stresses. Here, the response of different grapevine genotypes to UV-C radiation treatment was tested and the abundance of chlorophyll in the Hoe29 and Ke53 genotypes was observed to increase significantly within 6 h of UV-C treatment. Conversely, chlorophyll levels decreased markedly in the Augster Weiss and MĂŒller-Thurgau genotypes. Furthermore, stilbene abundance increased substantially in the Hoe29, Ke53, Ke83 and Pinot Blanc genotypes, but increased only slightly in Augster Weiss and MĂŒller-Thurgau. The expression of RESVERATROL SYNTHASE, which encodes a key enzyme in the stilbene synthesis pathway, increased in Hoe29, Ke53, Ke83 and Pinot Blanc following UV-C treatment, in a manner consistent with stilbene accumulation. In addition, we observed that reactive oxygen species (ROS) provide a key trigger in physiological responses and changes in secondary metabolite contents. In summary, the results from this study support a link between ROS, chlorophyll levels and genetic diversity for stilbene abundance in different grape genotypes, providing insights into mechanisms for plant physiological and biochemical responses and adaptations to stress

    The double control and its consistency with the double contingency principle

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    International audienceThe double contingency principle is implemented in French nuclear research and developmentfacilities. Regarding nuclear criticality safety in the CEA's Cadarache centre, the double controlprinciple was initiated in the LECA-STAR facility in the early 2000's and generalized to theother (approx. 20) nuclear installations since then.This paper presents the operational experience gathered from the beginning until now. Somesimple statistics are used to illustrate the reliability of the double control principle as appliedin the CEA/Cadarache facilities. The significant events registered at the ASN (AutoritĂ© de SĂ»retĂ©NuclĂ©aire – Nuclear Safety Authority) are analysed to demonstrate that defence in depthprevails and the failures that have occurred were detected and corrected by appropriatemeasure

    Automatized assessment of motor function in patients with NMD: MFM-Digital Study

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    International audienceGiven the progress of research and management in Spinal Muscular Atrophy (SMA), validated tools are needed to assess patients’ motor function. The Motor Function Measure assessment (MFM) is known as principal outcome measure of the motor function with an international recognition. It is a validated tool and sensitive to the change applicable in SMA.Clinicians from the Neuromuscular Diseases Department (Hospices Civils de Lyon, France) are developing the MFM-digital, an automated system to assess SMA patients’ motor function based on MFM. By using a Microsoft Kinect and a digital tablet, the objective is to improve reliability and acceptability of the MFM by lowering the measure’s subjectivity linked to heteroevaluation and by creating a hybrid serious-game.The feasibility study assesses the relevance of the system to capture postures and motions during a MFM test. Due to technological limits of capture by the Kinect sensor, 14 on 32 items may be recognized by the Kinect and 3 items by a tablet. In each case, the therapist scores items in live by referring to the MFM manual. Based on digital data coming from Kinect and tablet records, the principal investigator informs a blind score. The good correlation between items scoring by a therapist and items scoring on captured digital data show the possibility to use an algorithm to propose an automatic score.21 records of MFM were collected with Kinect and Tablet sensors. The first results are encouraging, showing a good concordance between the scores with tracks of improvements of the system in particular concerning the capture for weaker patients. The data supplied by the MFM-digital system bring additional data, in particular the duration of the items’ exercises and kinematic parameters.One interest of this work consists in creating an automatic measurement tool, based on the MFM-items, which has already shown its validity

    Automatic assessment of motor function in patients with Spinal Muscular Atrophy: MFM-digital study.

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    International audienceResults are encouraging to support the development of an automatized MFM. Additional work is needed to improve Kinect capture for weaker patient and to resolve interference problems. In study 2, MFM-Kinect protocol was included in a long list of tests during NatHis-SMA, witch could explain result differences between studies. The MFM-tablet results place the tablet in the assessment tools of the upper limb. The children showed a greater interest for the tablet application. The data supplied by the system MFM-digital bring additional data, in particular the timing of items' exercises and kinematic parameters which could refined the sensibility of MFM. We explore avenues of improvement of the system, in particular concerning the capture for weaker patients. The next step will be to use algorithms providing automatic scorings based on digital data and we are still looking for new digital technologies able to capture additional items.-Patients with Spinal Muscular Atrophy (SMA) type 2 or 3 (study1: 10 from the Escale department and study2: 14 from the NatHis-SMA study-NCT02391831) were included in the MFM-Kinect study. 14 items were scored by a therapist through standard MFM completion and from a blind scoring based on digital data coming from Kinect.-Patients with a NMD from 5 neuromuscular disorder departments were included in the MFM-Tablet study. Items 18, 19 and 22 were scored by a therapist through standard MFM completion on paper or using a digital tablet application. The Motor Function Measure (MFM), a validated and sensitive tool applicable to ambulant and non ambulant patients with neuromuscular disorders (NMD), is currently used as outcome measure in clinical studies. By using digital technologies, we want to create an automatized assessment based on MFM. The objectives are to improve the MFM reliability and its acceptability by turning the assessment into a serious game. Feasibility studies assessing the relevance of digital systems to capture postures and motions during a MFM test have shown that on 32 items of the MFM, 14 could be recognized by the Kinect and 3 by a digital tablet. Here we present preliminary studies to the conception of automated scoring systems. 119/140 records were interpretable. Some digital data were not analyzed because of capture problems with distortion skeleton, for example for patient with small amplitude movements or sitting on a wheelchair. On interpretable records, a great agreement between items scoring by a therapist and items blind scoring on captured digital data were found (75.6%). Differences between both studies concern as well concordance than interpretable capture. RESULTS MFM-DIGITAL TABLET 37 patients were included in the MFM-tablet (with inclusion still ongoing), with 11 DMD, 7 neuropathies, 6 SMA and 13 others. Median age of patients were 15.8 year [IQR: 9.4-43.8] and median of % MFM total score were 81.2 % [IQR: 59.4-87.5]. The agreement between scoring on paper vs tablet is excellent (Îș> 0.81) for items 18 and 22, good (Îș =0.61-0.8) for item 19. [1] BĂ©rard C. et al. A Motor Function Measure for Neuromuscular Diseases. Construction and validation Study. Neuromuscul Disord NMD. juill 2005;15(7):463-70. [2] www.mfm-nmd.org. Interface mods KiMe2 a software developed by the G-SCOP laboratory to record Kinect data and analyze items. Kinect data recorded are converted into biomechanical observables on kinematic graphs and 3D reconstruction allowing the item scoring using different data (angles, distances
) ANALYSIS PROCESS MFM-KINECT e.g. item 15: Place both hands on the head Microsoft Kinect is able to identify a silhouette and its articulations in a 3D space (digital skeleton) without any markers ITEMS STUDIED IN THE MFM-TABLET MFM-Kinect results Study 1 Study 2 Kinect records (N) 83 57 Error of capture (%): impossible analysis 7.2 26.3 Identical scoring (%): therapist vs digital data analysis 81.8 64.3 Patients' characteristic Study 1 Study 2 MFM test records (N) 10 14 Age (year)-median [IQR*] 10.7[10-11.5] 20.7[8.2-23.5] SMA Ambulant/non ambulant 5/5 2/12 MFM total score (%)-median [IQR] 58.3[28.9-78.6] 58.3[46.6-62] % identical score between paper vs digital tablet Weighted Kappa Coefficient ITEM 1

    Automatized assessment of motor function in patients with NMD: MFM-Digital Study

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    International audienceGiven the progress of research and management in Spinal Muscular Atrophy (SMA), validated tools are needed to assess patients’ motor function. The Motor Function Measure assessment (MFM) is known as principal outcome measure of the motor function with an international recognition. It is a validated tool and sensitive to the change applicable in SMA.Clinicians from the Neuromuscular Diseases Department (Hospices Civils de Lyon, France) are developing the MFM-digital, an automated system to assess SMA patients’ motor function based on MFM. By using a Microsoft Kinect and a digital tablet, the objective is to improve reliability and acceptability of the MFM by lowering the measure’s subjectivity linked to heteroevaluation and by creating a hybrid serious-game.The feasibility study assesses the relevance of the system to capture postures and motions during a MFM test. Due to technological limits of capture by the Kinect sensor, 14 on 32 items may be recognized by the Kinect and 3 items by a tablet. In each case, the therapist scores items in live by referring to the MFM manual. Based on digital data coming from Kinect and tablet records, the principal investigator informs a blind score. The good correlation between items scoring by a therapist and items scoring on captured digital data show the possibility to use an algorithm to propose an automatic score.21 records of MFM were collected with Kinect and Tablet sensors. The first results are encouraging, showing a good concordance between the scores with tracks of improvements of the system in particular concerning the capture for weaker patients. The data supplied by the MFM-digital system bring additional data, in particular the duration of the items’ exercises and kinematic parameters.One interest of this work consists in creating an automatic measurement tool, based on the MFM-items, which has already shown its validity
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