186,805 research outputs found

    Abstracts Book : XXVI - SILAE 2017 Societ√† Italo-Latinoamericana di etnomedicina y IX Congreso colombiano de cromatograf√≠a ‚Äď COCOCRO 2017

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    El presente documento recoge 2 investigaciones realizadas en modo ‚ÄúOral communications‚ÄĚ y 11 en modo ‚ÄúPoster‚ÄĚ presentadas para el congreso XXVI‚Äď SILAE 2017 Societ√† Italo-Latinoamericana di etnomedicina y IX Congreso colombiano de cromatograf√≠a ‚Äď COCOCRO 2017; realizado en Cartagena. Estos res√ļmenes recogen la investigaci√≥n sobre la leishmaniasis y el desarrollo de fitomedicinas basadas en plantas, que permitan tratar la esta condici√≥n y sus manifestaciones como medicinas alternativas, que sean efectivas y a bajo costo. Los trabajos presentados fueron: ‚ÄúOral communications‚ÄĚ: (1) Cytotoxicity and leishmanicidal activity of essential oil from plants present in Colombia and commonly used in traditional medicine; (2) Studies in vitro and in vivo of antileishmanial activity and differential cytotoxicity of Cannabis spp. En modo ‚ÄúPoster‚ÄĚ (1) Phytochemistry and ethnopharmacological research on isla grande, Cartagena; (2) Ethnobotanical study of medicinal plants in Isla Grande, Cartagena Colombia; (3) In vitro evaluation of interaction of anti-inflammatory, wound healing and anti-leishmanial activities. An useful strategy to identify hit compounds for drug development to treat cutaneous leishmaniasis; (4) Chemical composition and evaluation of the biological potential of three vegetable species of the caribbean region; (5) Characterization by means of gas chromatography / mass spectrometry (gc / ms) and evaluation of the antibacterial activity of the essential oil of the bark from Astronium graveolens; (6) Synthesis and trypanocide activity of chloro and bromo l-tyrosine derivatives; (7) Leishmanicidal and citotoxic activity of benzothiopyrans. Structure-activity relationship; (8) Chemical composition, antioxidant activity, antimicrobial and antiprotozoal properties of ethanol propolis extracts of Bolivia; (9) Leishmanicidal activity and cytotoxicity in vitro of styrylquinolines; (10) Antileishmanial activity of rich fractions in alkaloid and flavonoid to design and develop a new low cost topical phytomedicine product from medicinal plants in the northern coast of Colombia; (11) Synthesis, leishmanicidal activity and chiral resolution of 4-oxothiochromane-2-carboxylic acid and its esters and amides derivatives.Departamento Administrativo de Ciencia, Tecnolog√≠a e Innovaci√≥n [CO] Colciencias1107-569-33684Aislamiento y purificaci√≥n de compuestos con potencial actividad antileishmanial a partir de Cordia dentada Poir. y Heliotropium indicum L.n

    Contributors and moderators of quality of life in caregivers of Alzheimer¬īs disease patients

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    Aim and objective: This study aimed to identify the variables that contributed to Quality of Life (QoL) of Alzheimer's Disease (AD) caregivers, taking into consideration the caregiving context, stressors, role strains, and resources.Methods: The sample included 102 caregivers of AD patients who answered the following instruments: Depression, Anxiety and Stress Scale-21; Satisfaction with Social Support Scale; Revised Memory and Behavioral Problems Checklist; Family Communication and Satisfaction Scales; Spiritual and Religious Attitudes in Dealing with Illness; and Quality of Life in Alzheimer's Disease - Caregiver Version.Results: Caregivers who were employed, chose the caregiving role, and received help in caring showed better QoL. Also, being younger, less caregiving daily hours, caring for patients with less memory and behavior problems, lower distress, and family satisfaction predicted better QoL. Finally, spirituality was a moderator between family communication and QoL but not between family satisfaction and QoL.Conclusion: Caregiving-context variables (age, professional status, choosing to care, receiving help in the caregiving role and duration of daily care); role strains (family dissatisfaction); stressors (caregivers' distress and patients' memory and behavioral problems); and resources (spirituality) had an impact on caregivers' QoL emphasizing the adequacy of the Stress Process Model. Intervention should also focus on spirituality given its moderating role

    Optimizations of Autoencoders for Analysis and Classification of Microscopic In Situ Hybridization Images

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    Currently, analysis of microscopic In Situ Hybridization images is done manually by experts. Precise evaluation and classification of such microscopic images can ease experts' work and reveal further insights about the data. In this work, we propose a deep-learning framework to detect and classify areas of microscopic images with similar levels of gene expression. The data we analyze requires an unsupervised learning model for which we employ a type of Artificial Neural Network - Deep Learning Autoencoders. The model's performance is optimized by balancing the latent layers' length and complexity and fine-tuning hyperparameters. The results are validated by adapting the mean-squared error (MSE) metric, and comparison to expert's evaluation.Comment: 9 pages; 9 figure

    Molecular species phylogeny and ortholog sharing.

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    (A) The quantitative maximum likelihood species phylogeny computed from the concatenated superalignment of 1,627 orthologous protein-coding genes places the sand flies (Psychodomorpha) as a sister group to the mosquitoes (Culicomorpha) rather than the flies (Muscomorpha), with all branches showing 100% bootstrap support. The Culicomorpha are represented by four Anopheles mosquito species and Culex quinquefasciatus and the Muscomorpha include four Drosophila fruit fly species and the tsetse fly, G. morsitans. Outgroup species represent Lepidoptera (Bombyx mori), Coleoptera (T. castaneum), Hymenoptera (Apis mellifera), and the phylogeny is rooted with the phthirapteran human body louse, Pe. humanus. The inset boxplots show that single-copy (1:1) and multi-copy (X:X) ortholog amino acid percent identity is higher between each sand fly (Ll, Lu. longipalpis; Pp, Ph. papatasi) and An. gambiae (Ag) than D. melanogaster (Dm). Boxplots show median values with boxes extending to the first and third quartiles of the distributions. (B) The Venn diagram summarizes the numbers of orthologous groups and mean number of genes per species (in parentheses) shared among the two sand flies (L. lon., Lu. longipalpis; P. pap., Ph. papatasi) and/or the Culicomorpha and/or the Muscomorpha. Analysis of ortholog sharing shows that the sand flies share more than three times as many orthologous groups exclusively with the Culicomorpha (Anopheles and Culex) compared to the Muscomorpha (Drosophila, Glossina) (subsets highlighted with thin and thick dashed lines). Numbers of unique genes are in italics. Colors in panel A and panel B match species and sets of species analyzed.</p

    Heat shock and hypoxia gene family annotation.

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    Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites.</div

    Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

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    Summary: Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results in a more favorable iWAT structural phenotype. Using biochemical, imaging, and multi-omics analyses, we find that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation. We identify adipose stem cells as one of the main contributors to training-induced ECM remodeling, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Moreover, we find that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism

    Data by Schneider et al. (2023) Remote sensing-based forest modeling reveals positive effects of functional diversity on productivity at local spatial scale

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    Datasets from the scientific article by Schneider, et al. (2023).  Remote sensing-based forest modeling reveals positive effects of functional diversity on productivity at local spatial scale. Please cite: Schneider, F. D., Longo, M., Paul-Limoges, E., Scholl, V. M., Schmid, B., Morsdorf, F., Pavlick, R. P., Schimel, D. S., Schaepman, M. E. & Moorcroft, P. R. (2023). Remote sensing-based forest modeling reveals positive effects of functional diversity on productivity at local spatial scale. JGR Biogeosciences.</p

    Influence of the downwash airflow in Hexacopter Drone on the spray distribution pattern of boom sprayer

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    The spray characteristics of drone sprayers are significantly influenced by the downwash airflow produced by Drone multi-rotors. The present study aimed to study the influence of downwash airflow and the operational parameters of Drone sprayer, viz., flight height, travel speed, rotor configuration, payload and wind velocity on the spray distribution pattern for boom sprayer attachment to Drone. The boom type sprayer consisted of four numbers of flat fan nozzles placed at three different spacing viz., 30, 45 and 60 cm between each nozzle. The spray distribution pattern of the Hexacopter Drone was studied at three different operating pressures, viz., 3.0, 4.0 and 5.0 kg cm-2. A spray patternator of 5 m x 5 m was developed per the Bureau of Indian Standards (BIS) standard to study the spray uniformity of volume distribution pattern. The best spray uniformity was found as 0.37 % CV value at 60 cm nozzle spacing and 4 kg cm-2 operating pressure. The optimised parameters viz., 60 cm of nozzle spacing and 4 kg cm-2 operating pressure, the influence of downwash airflow on the spray volume distribution of hexacopter Drone with boom spray attachment were studied. The Drone hovered at three different heights, viz., 1.0, 2.0 and 3.0 m from the top of the patternator and spray operating pressure was maintained at 4 kg cm-2. It was observed that less volume of spray was collected at the middle portion when the Unmanned Aerial Vehicle (UAV) was hovered at 1.0 m height due to the direct impact of downwash airflow of rotors. The uniform spray volume distribution pattern was observed when Drone hovered from 1.0 m to 3.0 m height. A round vertex pattern of spray pattern was generated with boom type nozzles configuration due to the direct impact of downwash airflow of rotors. This study will be helpful in the configuration of nozzles attached to the drone sprayers, optimization of spray operational parameters, and revealing spray volume distribution pattern

    TOI-969: a late-K dwarf with a hot mini-Neptune in the desert and an eccentric cold Jupiter

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    Context. The current architecture of a given multi-planetary system is a key fingerprint of its past formation and dynamical evolution history. Long-term follow-up observations are key to complete their picture. Aims. In this paper, we focus on the confirmation and characterization of the components of the TOI-969 planetary system, where TESS detected a Neptune-size planet candidate in a very close-in orbit around a late K-dwarf star. Methods. We use a set of precise radial velocity observations from HARPS, PFS, and CORALIE instruments covering more than two years in combination with the TESS photometric light curve and other ground-based follow-up observations to confirm and characterize the components of this planetary system. Results. We find that TOI-969 b is a transiting close-in (Pb ‚ąľ 1.82 days) mini-Neptune planet (Formula Presented), placing it on the lower boundary of the hot-Neptune desert (Teq,b = 941 \ub1 31 K). The analysis of its internal structure shows that TOI-969 b is a volatile-rich planet, suggesting it underwent an inward migration. The radial velocity model also favors the presence of a second massive body in the system, TOI-969 c, with a long period of (Formula Presented) days, a minimum mass of (Formula Presented), and a highly eccentric orbit of (Formula Presented). Conclusions. The TOI-969 planetary system is one of the few around K-dwarfs known to have this extended configuration going from a very close-in planet to a wide-separation gaseous giant. TOI-969 b has a transmission spectroscopy metric of 93 and orbits a moderately bright (G = 11.3 mag) star, making it an excellent target for atmospheric studies. The architecture of this planetary system can also provide valuable information about migration and formation of planetary systems
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