10 research outputs found

    Vaginal atrophy in breast cancer survivors: attitude and approaches among oncologists

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    Abstract Background Vulvovaginal atrophy (VVA) is a relevant problem for breast cancer survivors (BCSs), in particular for those who receive aromatase inhibitors (AIs). We conducted a survey, to assess the attitude of oncologists toward the diagnosis and treatment of VVA in BCSs. Materials and Methods In 2015, 120 computer-assisted Web interviews were performed among breast oncologists. Results According to oncologists' perceptions, 60% of postmenopausal BCSs and 39.4% of premenopausal BCSs will suffer from VVA. Despite that none of the physicians considered VVA as a transient event or a secondary problem in BCSs, only half of the oncologists (48%) directly illustrated VVA to the patients as a possible consequence. Forty-one percent of the oncologists refer BCSs to gynaecologist to define VVA treatment, whereas 35.1% manages it alone. Nonhormonal treatments are preferred by most oncologists (71%). The main reason not to prescribe vaginal estrogen therapy in BCSs is the fear of increased cancer recurrence, the possible interference with tamoxifen, or AIs and the fear of medical litigation. Conclusion VVA is a relevant problem for BCSs. Great effort should be done to correctly inform health care providers about VVA problems and on the different possible available treatments

    The ABC130 barrel module prototyping programme for the ATLAS strip tracker

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    For the Phase-II Upgrade of the ATLAS Detector, its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100 % silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-25) and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.Comment: 82 pages, 66 figure

    Can physical and cognitive training based on episodic memory be combined in a new protocol for daily training?

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    Background: Cognitive training (CT) is defined as guided practice on a set of standard tasks designed to stimulate particular cognitive functions. Recent studies have shown that physical exercise is beneficial for cognitive activity in older adults and patients with degenerative diseases. Aims: The main objective of the present study is to create a new cognitive tool able to provide training for cognitive functions that take advantage of the physical activity involved in the execution of the task. A study concerning the application of a new CT tool for episodic memory is presented and divided in two parts. The first one aims at developing a new sensorized device, called SmartTapestry, for physical and cognitive training. The second part aims at understanding its technical viability and level of sensitivity in stimulating the same cognitive domain covered by the standardized tests, despite the introduction of the physical activity variable. Methods: The SmartTapestry device was tested with a total of 53 subjects, 29 healthy subjects and 24 subjects suffering from mild cognitive impairment. Results and discussions: The results show a good correlation between the two approaches (p < 0.005), suggesting that SmartTapestry can stimulate the same cognitive functions of traditional cognitive tasks, with the addition of physical exercise. Conclusions: The results of this study may be useful in designing ecological and combined cognitive-physical tools, which can be used daily at home, reducing the presence of clinical staff, to train at the same time the brain and the body so as to improve the cognitive treatments efficacy

    VALUTAZIONE DELL\u27IMPATTO DEL RUMORE AEROPORTUALE SULLA SALUTE DELLA POPOLAZIONE RESIDENTE NELLEVICINANZE DI SEI AEROPORTI ITALIANI

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    .Introduzione Nell\u27ultima decade il grande successo dei voli low-cost ha aumentato il traffico aereo in molti aeroportiitaliani, esponendo la popolazione residente ad un aumento dei livelli di rumore e di inquinamento atmosferico. Obiettivi Nell\u27ambito del progetto SERA Italia (Studio sugli Effetti del Rumore Aeroportuale) ? stata condotta una Valutazione d\u27Impatto Sanitario del rumore aeroportuale tra i residenti in prossimit? degli aeroporti di Ciampino (Roma), Linate e Malpensa (Milano), SanGiusto (Pisa), Caselle (Torino) e Tessera (Venezia) con l\u27obiettivo di fornire metodologie e strumenti operativi per l\u27avvio di sistemi di sorveglianza, in materia di inquinamento acustico ed atmosferico,della popolazione residente nei pressi dei principali aeroporti italiani. Metodi I registri anagrafici dei comuni interessati hanno fornito gli indirizzi di tutti i residenti al 31/12/2010. L\u27impatto acustico al 2011 di ciascun aeroporto ? stato stimato utilizzando il modello Integrated Noise Model. Tutti gli indirizzi di residenza sono stati geocodificati e ad ogni soggetto ? stata attribuita l\u27esposizione a diversi indicatori d\u27impatto acustico: Lden (<55, 55-60, 60-65, 65-70 dB), Lnight, Leq diurno e notturno. Sono state utilizzate le funzioni concentrazionerisposta disponibili dalla letteratura per stimare il numero di casi attribuibili al rumore aeroportuale. Sono state considerate le seguenti condizioni: ipertensione, infarto miocardico acuto (IMA), annoyance e disturbi del sonno. Risultati Sono stati considerati 73.272 residenti esposti a rumore aeroportuale superiore a 55 dB, di cui 55.915 (76,3%) a 55-60 dB, 16.562 (22,6%) a 60-65 dB e 795 (1,2%) a 65-70 dB. Le stime risultanti dalle funzioni concentrazionerisposta indicano che in un anno l\u27esposizione a livelli di rumore aeroportuale maggiori di 55 dB ha causato nella popolazione studiata 1.595 (95%IC: 0-3.435) casi addizionali di ipertensione, 3,4 (95%IC: 0-10,7) casi di IMA, annoyance in 9.789 persone (95%IC:6.895-11.962) e disturbi del sonno in 5.084 soggetti (95%IC: 1.894-10.509). Conclusioni Lo studio SERA evidenzia un impatto rilevante del rumore aeroportuale sulla salute dei residenti nei pressi dei sei aeroporti italiani. Sono opportune la valutazione epidemiologica continua e urgenti misure di mitigazione del rumore per tutelare la salute dei residenti

    The ABC130 barrel module prototyping programme for the ATLAS strip tracker

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    For the Phase-II Upgrade of the ATLAS Detector [1], its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100% silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-250) [2,2] and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests

    Search for dark matter in association with an energetic photon in pp collisions at s = 13 TeV with the ATLAS detector

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    Abstract: A search for dark matter is conducted in final states containing a photon and missing transverse momentum in proton-proton collisions at s = 13 TeV. The data, collected during 2015‚Äď2018 by the ATLAS experiment at the CERN LHC, correspond to an integrated luminosity of 139 fb‚ąí1. No deviations from the predictions of the Standard Model are observed and 95% confidence-level upper limits between 2.45 fb and 0.5 fb are set on the visible cross section for contributions from physics beyond the Standard Model, in different ranges of the missing transverse momentum. The results are interpreted as 95% confidence-level limits in models where weakly interacting dark-matter candidates are pair-produced via an s-channel axial-vector or vector mediator. Dark-matter candidates with masses up to 415 (580) GeV are excluded for axial-vector (vector) mediators, while the maximum excluded mass of the mediator is 1460 (1470) GeV. In addition, the results are expressed in terms of 95% confidence-level limits on the parameters of a model with an axion-like particle produced in association with a photon, and are used to constrain the coupling gaZő≥ of an axion-like particle to the electroweak gauge bosons

    Observation of WWW Production in pp Collisions at ‚ąös = 13 TeV with the ATLAS Detector