2 research outputs found

    Prevalence of Clinical Symptoms of COVID-19 in Pediatrics: A Systematic Review and Meta-Analysis

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    Background & aim: COVID-19 has numerous and diverse clinical symptoms in different groups, which highlights the identification of common symptoms in children as silent carriers and the timely identification of patients to control the spread of this disease. Therefore, the aim of the present study was to determine and investigate the prevalence of clinical symptoms of COVID-19-19 in children. Methods: The present review and meta-analysis study was conducted according to PRISMA guidelines. The prevalence of symptoms as identification factors of children with COVID-19 at the time of arrival to the hospital between January 2020 and April 2022 was investigated. Articles used in international and domestic databases using the keywords "children", "children", "Covid-19", "symptoms", "clinical symptoms", "fever", "diarrhea", "vomiting" ", "shortness of breath", "cough", "headache", "nausea", "shivering", "body pain", "fatigue" and "malaise" were searched. The collected data were evaluated using the Egger test to check the diffusion error and heterogeneity using the I2 test. Results: In order to determine the prevalence of symptoms of covid-19 in children, a total of 261 articles were received, and finally 21 articles were considered in the analysis. In general, 2200 patients were examined in the present study. According to the results, fever with an overall prevalence of 47% and a confidence interval of 95% (38.96-50.50) is the highest symptom and diarrhea with an overall prevalence of 6.69% and a confidence interval (5.42-8.05) is the lowest. Conclusion: According to the results of the present study, fever and cough were two prominent symptoms of the covid-19 disease in children, and considering that these two symptoms are common symptoms in most children's diseases, during the current epidemic, it is necessary to identify sick children or be considered contaminated

    Genetic variations of OprD porin protein in imipenem resistant clinical isolates of Pseudomonas aeruginosa in burn patients

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    Background: Drug resistance is one of the important threats in uncontrolled infections by Pseudomonas aeruginosa, an opportunistic nosocomial pathogen, in burn patients. The presence of OprD porin protein in the bacterial cell wall is one of the mechanisms for resistance against hydrophilic drugs in this bacterium. Objective: The aim of this study was to evaluate genetic sequence rearrangements of OprD gene in imipenem resistant clinical isolates of pseudomonas aeruginosa in burn patients. Methods: This cross sectional study was performed in Ghotbeddin Shirazi Hospital from October 2013 to February 2015. A total of 253 wound samples were evaluated for Pseudomonas aeruginosa. All isolates were evaluated using specific sequencing of the target region. Genetic sequence rearrangements were compared with the sensitivity pattern of the isolates to the imipenem. Findings: Pseudomonas aeruginosa was found in 22% of the samples in Shiraz burn center. More than 90% of the isolates were multi drug resistant while only 25% were sensitive to imipenem. More than 80% of the imipenem resistant isolates had rearrangement in the gene associated with OprD protein. Conclusion: With regards to the results, it seems that Pseudomonas aeruginosa, as a prevalent microorganism in burn wounds, has rearrangement in the gene associated with OprD porin protein. This rearrangement may play a role in drug resistance of the Pseudomonas aeruginosa isolates in hospitalized patients