Occupational Nature of Social Participation for Adolescent Males with Learning Disorders

OBJECTIVE. This study explored the effects of community team sports on social participation and life habit development for males ages 12-17 with a documented learning disorder. METHOD. A causal/comparative design compared two groups. A convenient sample of 24 participants completed Life Habits Questionnaire and Community Integration Questionnaire. Chi-square and T-test analysis were used. RESULTS. Results indicated social integration (t=4.56, p=.00) for boys who played a community sport was significantly higher than boys who did not play a community sport. The number and performance level of life habits was also significantly higher for boys who played a community team sport (t=3.23, p=.00). CONCLUSION. Community team sports positively influence both social participation and life habits associated with social responsibilities for adolescent boys with learning disorders. Occupational therapists should promote involvement in team sports as an adjunct to therapy or consider community team sport involvement as treatment improving social participation outcomes

In the Flesh and the Gothic Pharmacology of Everyday Life; or Into and Out of the Gothic

One of the key questions facing Gothic Studies today is that of its migration into and out of its once familiar generic or symbolic modes of representation. The BBC series In the Flesh addresses these concerns against the background of a neoliberal medical culture in which pharmaceutical treatments have become powerful tools of socio-economic normalization, either through inducing passivity or in heightening productivity, generating chemically adapted biomachines tuned to think and produce. But the pharmakon has always been a risky form of normalization, its poisonous mechanisms threatening to undo its helpful patterns by stealth. This essay discusses the pharmacological and medical contexts of the series in which zombies are subjected to medical management and normalized as “PDS sufferers,” thereby locating In the Flesh in terms of an already gothicized neoliberal pharmacology of everyday life. It also enquires how the proximity of the symbolic pharmacology of the series to neoliberal medical discourses and practices actually challenges traditional representational patterns of the Gothic and whether the Gothic can still have a role as an alternative cure to society’s ills

Legal Impediments to Service: Women in the Military and the Rule of Law

Some of those who served did so by disguising themselves as men.6 A number of women had served as spies, as was the case of Rose O\u27Neal Greenhow, who was arrested and imprisoned for supplying the Confederate Army with information, and Pauline Cushman, who was sentenced to be executed as a Union spy during the War Between the States.7 The first woman to receive the Congressional Medal of Honor, Dr. Mary Walker, provided her services as a doctor free of charge to Union forces in Virginia and Tennessee.8 She had asked the Union Army to hire her as a doctor, but it refused.9 Despite its refusal to hire her, Dr. Walker continued to provide medical services to Union soldiers.10 Eventually, she was captured by Confederate soldiers.11 After her release from Confederate prison as part of a prisoner exchange, she was given an official position of Acting Assistant Surgeon, the first woman to be given such a title.12 Dr. Walker received the Congressional Medal of Honor after the war.13 In 1917, however, the U.S. Congress attempted to remove the honor from her, stating that only those who fought in combat were entitled to the award.14 When the Congress decided that the Medal had been awarded in error, Walker refused to return the medal.15 Even after her death, Dr Walker\u27s family continued to battle to resolve her status as a Medal of Honor recipient. [...] women were not afforded the right to vote in any state in any election before achieving the right to vote in school board elections in Kentucky in 1838.18 Passage of the Nineteenth Amendment in 1920 gave women the right to vote in national elections across the country.19 Similarly, women were not entitled to administer estates, own property, or enter into contract in their personal capacity.\n Perhaps it is unsurprising that, more than forty years after the Civil Rights Act of 1964, members of the legislative branch, as well as those in positions to engender policy for and within the U.S. military, continue to limit opportunities for women in fields in which they have a proven competence

Improving urban public schools: suggestions for teacher union leaders

In an earlier session of this conference, one participant asked the panelists what advice they would give to an audience of union leaders representing teachers from urban public schools. In response to that question, I offer seven suggestions. Following my explanations of those suggestions, I conclude with slightly different versions that I believe serve as relevant advice to local and state educational policymakers.Education

Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro.

Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies. There is limited understanding if this response to an inhaled stimulus is adverse or adaptive, and additionally if it is a transient or irreversible process. The aim of this study was to evaluate whether high content image analysis could distinguish between different drug-induced foamy macrophage phenotypes and to determine the extent of the reversibility of the foamy phenotypes by assessing morphological changes over time. Alveolar-like macrophages derived from the human monocyte cell line U937 were exposed for 24 h to compounds known to induce a foamy macrophage phenotype (amiodarone, staurosporine) and control compounds that are not known to cause a foamy macrophage phenotype in vitro (fluticasone and salbutamol). Following drug stimulation, the cells were rested in drug-free media for the subsequent 24 or 48 h. Cell morphometric parameters (cellular and nuclear area, vacuoles numbers and size) and phospholipid content were determined using high content image analysis. The foamy macrophage recovery was dependent on the mechanism of action of the inducer compound. Amiodarone toxicity was associated with phospholipid accumulation and morphometric changes were reversed when the stimulus was removed from culture environment. Conversely cells were unable to recover from exposure to staurosporine which initiates the apoptosis pathway. This study shows that high content analysis can discriminate between different phenotypes of foamy macrophages and may contribute to better decision making in the process of new drug development.Peer reviewedFinal Published versio

Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines

Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. As a first step towards this investigation, “clean” lactose, with removed fines, was produced via wet decantation. Ethanol and isopropyl alcohol have been used in wet decantation, successfully removing lactose fines from the surface of the coarse particles. Differential Scanning Calorimetry (DSC) was employed to show that the powders maintained their crystalline character. Scanning Electron Microscopy (SEM) showed tomahawk-shaped particles in all the powders and some surface alteration occurring after decantation. An airflow titration method using laser diffraction (LDA) allowed the estimation of the removal of fines as well as the particle size distributions, while the non-polar and the polar components of the surface energy of the powders were calculated via Inverse Gas Chromatography-Surface Energy Analysis (iGC-SEA). As both solvents successfully removed fines, we propose the addition of isopropyl alcohol in the list of organic solvents suitable for this purpose.Peer reviewe

Standards, information, and the demand for student achievement

Higher student achievement, say the authors, has been severely hampered by a lack of good information comparing achievement levels with today's labor market requirements. They argue that by obtaining this information--in the form of academic standards and assessments--parents can more accurately evaluate the quality of their children's education.Education

‘Great ease and simplicity of action’: Dr Nelson’s Inhaler and the origins of modern inhalation therapy

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Unveiled at the conclusion of a meeting of the Royal Medical and Chirurgical Society in 1861,[1] ‘Dr Nelson’s Improved Inhaler’ was one of the most important milestones in the genesis of reliable treatment of respiratory ailments in the modern era. Affordable and suitable for self-medication, the Dr Nelson’s Inhaler offered simple and reliable relief for patients with respiratory and pulmonary ailments. Conspicuous for its modesty and simplicity, it was one of the most widely produced, reproduced, and used inhalation devices in the final third of the nineteenth century. By reconstructing the ‘biography’ of the Nelson Inhaler, this article will attempt to sketch a network of medical and commercial interests and expertise in London which aligned in the 1860s to help establish inhalation as a popular, inexpensive, and trusted form of medical therapy for pulmonary ailments. This article will look at what connects physicians, apothecaries, and patients in the era: the medicines and technologies that were prescribed, made, bought, and which caused wellness, side-effects, and even death. This approach allows us to develop a narrative of respiratory illness as it was experienced by practitioners and patients alike.Peer reviewe

Improving the Performance of the Education Sector: The Valuable, Challenging, and Limited Role of Random Assignment Evaluations

In an attempt to improve the quality of educational research, the U.S. Department of Education%u2019s Institute of Education Sciences has provided funding for 65 randomized controlled trials of educational interventions. We argue that this research methodology is more effective in providing guidance to extremely troubled schools about how to make some progress than guidance to schools trying to move from making some progress to becoming high performance organizations. We also argue that the conventional view of medical research -- discoveries made in specialized laboratories that are then tested using randomized control trials -- is an inaccurate description of the sources of advances in medical practice. Moreover, this conventional view of the sources of advances in medical practice leads to incorrect inferences about how to improve educational research. We illustrate this argument using evidence from the history of medical research on the treatment of cystic fibrosis.