A statistical method for revealing form-function relations in biological networks

Over the past decade, a number of researchers in systems biology have sought to relate the function of biological systems to their network-level descriptions -- lists of the most important players and the pairwise interactions between them. Both for large networks (in which statistical analysis is often framed in terms of the abundance of repeated small subgraphs) and for small networks which can be analyzed in greater detail (or even synthesized in vivo and subjected to experiment), revealing the relationship between the topology of small subgraphs and their biological function has been a central goal. We here seek to pose this revelation as a statistical task, illustrated using a particular setup which has been constructed experimentally and for which parameterized models of transcriptional regulation have been studied extensively. The question "how does function follow form" is here mathematized by identifying which topological attributes correlate with the diverse possible information-processing tasks which a transcriptional regulatory network can realize. The resulting method reveals one form-function relationship which had earlier been predicted based on analytic results, and reveals a second for which we can provide an analytic interpretation. Resulting source code is distributed via http://formfunction.sourceforge.net.Comment: To appear in Proc. Natl. Acad. Sci. USA. 17 pages, 9 figures, 2 table

The 2010 Census—What Your Community Needs To Know

This presentation features: The Magnitude of the 2010 Census; Nebraska Effort; 2010 Census Key Dates; The Questionnaire; Questionnaire Content; Type of Enumeration; Nebraska Type of Enumeration; Participation Rate Feedback Program; State/Local Participation Rates; Partnership Activities; 2010 Census --Why It Matters; The Use of Census Bureau Data is About…; Census Data and Federal Funding; 2010 Census Data Can Help Your Community Answer Questions Like…; Brief Data Overview; 2010 Census Geography; Small Area Hierarchy Census Tracts, Block Groups, Blocks; 2010 Census Data Products; 2010 Census Data Release Schedule; Redistricting Data File; Demographic Profile; American Factfinder Data Retrieval System; ACS and 2010 Census; American Community Survey: What is it?; ACS Characteristics; ACS Data Products; Compass Products—How Can I Access ACS Data; Population Estimates; Nebraska Places, 2009; Major Surveys Conducted by the Census Bureau; How the Data are used; Percent moving in 5 years by ZIP; Transportation planning; Bike/Walk modeling; Estimating travel characteristics; School districts; Political/Statistical Geographic Hierarchy; Percent of Children Under 18 Years Below Poverty Level in the Past 12 Months; Grand Island Public Schools, School Enrollment: 2006-08; Faith-Based; Community organizations; Percent over 25 with college TM-P042. Percent of Persons 25 with college degrees by Zip; Noise pollution; Environmental justice; Growth impacts; Business – Gauge the Competition, Market Share and Site Location; Workers in UN-O zipcode; Percent over 65 with disability by block group; Business - Labor force; Percent of workers in Production, Transportation and Material Moving by block group; Transportation industry average monthly wages, 1999- 2009; and Partnership and Data Services Program