Speculations on a privileged state of cognitive dissonance

This paper examines two commonly held and conflicting cognitions in the modern world, each based on a belief vital to the individual's sense of self, both maintained in what is here considered as a chronic state of dissonance. This psychological inconsistency consists of an inherent practical belief in the goodness of empirical knowledge and a culturally-developed transcendent belief denying, or at least mitigating, empirical evidence about the finite nature of individual life and affirming a counter-empirical belief in supernatural: supra-cause-and-effect forces that influence life. I argue that since both beliefs are highly resistant to change, they lead to an impasse that individuals in diverse cultures have borne and been motivated to maintain. They have borne it, as I hope to show, because the consonant “cure” has proved to be more discomforting than the dissonant condition. \ud \u

On Evolution of God-Seeking Mind: An Inquiry Into Why Natural Selection Would Favor Imagination and Distortion of Sensory Experience

The earliest known products of human imagination appear to express a primordial concern and struggle with thoughts of dying and of death and mortality. I argue that the structures and processes of imagination evolved in that struggle, in response to debilitating anxieties and fearful states that would accompany an incipient awareness of mortality. Imagination evolved to find that which would make the nascent apprehension of death more bearable, to engage in a search for alternative perceptions of death: a search that was beyond the capability of the external senses. I argue that imagination evolved as flight and fight adaptations in response to debilitating fears that paralleled an emerging foreknowledge of death. Imagination, and symbolic language to express its perceptions, would eventually lead to religious behavior and the development of cultural supports. Although highly speculative, my argument draws on recent brain studies, and on anthropology, psychology, and linguistics

Invite your representative to work. Change the world. Here's how.

Today's political climate can seem hostile to science. Alternative facts, climate change denial, and relabeling of actual news as fake news are discouraging phenomena for sure. But these trends make it more important than ever to engage our politicians. Take heart! There is something you can do. You can show your representatives firsthand the amazing things you do, evidence of the economic engine that your activities generate, and the real people behind the discoveries. I did, and it was fun. We invited our congressman to the University of California, Santa Barbara (UCSB), and he accepted! For 2 hours, we explained and demonstrated efforts to cure blindness using stem cells, the medical implications of the discovery that cells can recover from the brink of death, a mosquito lab striving to eliminate insect-borne disease, and an Alzheimer's disease laboratory. Salud Carbajal peered through a microscope and met real scientists. Before his visit, he did not know what a postdoctoral fellow was, much less what stem cells look like. When he left he knew our names, how much money we bring into his district, and how important National Institutes of Health funding and international mobility are to our enterprise. Although I live in the United States, this approach should also apply to other democratic countries. If each of us converts one representative into a science champion, we can change the world

Q&A: Cellular near death experiences-what is anastasis?

Apoptosis is a form of programmed cell death that is carried out by proteolytic enzymes called caspases. Executioner caspase activity causes cells to shrink, bleb, and disintegrate into apoptotic bodies and has been considered a point of no return for apoptotic cells. However, relatively recent work has shown that cells can survive transient apoptotic stimuli, even after executioner caspase activation. This process is called anastasis. In this Q&A, we answer common questions that arise regarding anastasis, including how it is defined, the origin of the name, the potential physiological consequences, molecular mechanisms, and open questions for this new field of study

TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.

Avoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature. These cellular and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature increase. We propose that larvae use low-threshold sensors in the brain to monitor rapid temperature increases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the temperature of the brain rises to dangerous levels

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.

Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool. Here we use quantitative analysis of Wnt, Hh, and Notch signalling reporters and the cell fate markers Eyes Absent (Eya) and Castor (Cas) to study the effects of hyper-activation and loss of niche signals on progenitor development in the Drosophila ovary. Follicle stem cell (FSC) progeny adopt distinct polar, stalk, and main body cell fates. We show that Wnt signalling transiently inhibits expression of the main body cell fate determinant Eya, and Wnt hyperactivity strongly biases cells towards polar and stalk fates. Hh signalling independently controls the proliferation to differentiation transition. Notch is permissive but not instructive for differentiation of multiple cell types. These findings reveal that multiple niche signals coordinate cell fates and differentiation of progenitor cells

Singing The Glory Down: Amateur Gospel Music in South Central Kentucky, 1900-1990

In Singing the Glory Down, William Lynwood Montell contributes to a fuller understanding of twentieth-century American culture by examining the complex relationships between gospel music and the culture of the nineteen-county study area in which this music has flourished for a hundred years. He has recorded the memories and feelings of those who were young while the movement gathered steam and who remember it at its high point, and stories about those who have passed over that river about which they loved to sing. In the early 1900s, a singing school or gospel convention was a major social event that enticed people to walk for miles to learn to sing or to hear someone who already had. The shape-note teachers of those days conducted days or even weeks of nightly practice, which culminated in a performance that confirmed the teacher\u27s skill. Quartet music originated in these settings. Today, some area quartets still sound much like those early groups; others teach themselves to sing by imitating their favorite professional gospel ensembles. They travel every weekend in buses emblazoned with the names of their groups, with tapes and albums to sell. Through all the changes, the four-part southern harmony of Kentucky gospel music has remained the same. In the words of these performers, through letters, diaries, and interviews, Montell details the attitudes and joys of those involved most deeply in the gospel music scene. He also brings the reader into their personal relationships, their professional jealousies, and their struggles to keep alive the music they love. William Lynwood Montell, professor of folk studies at Western Kentucky University, is the author of several books, including The Saga of Coe Ridge and Killings. Provides a much-needed antidote to the stereotype of the modern gospel singer as a slick, money-minded professional whose polyester suits are monuments to bad taste. —Journal of Southern History Ranks as a significant study in the history of American vernacular music. —Oral History Review The story of the rise, decline, and stubborn survival of the shape-note gospel tradition in south central Kentucky. Montell has tirelessly scouted out the many groups and provides a description of them and their musical world. An important study of a folk tradition. —American Musichttps://uknowledge.uky.edu/upk_music/1006/thumbnail.jp

The evolution and comparative neurobiology of endocannabinoid signalling

CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol lipase alpha and acts via presynaptic CB(1)-type cannabinoid receptors to inhibit neurotransmitter release. Electrophysiological studies on lampreys indicate that this retrograde signalling mechanism occurs throughout the vertebrates, whereas system-level studies point to conserved roles for endocannabinoid signalling in neural mechanisms of learning and control of locomotor activity and feeding. CB(1)/CB(2)-type receptors originated in a common ancestor of extant chordates, and in the sea squirt Ciona intestinalis a CB(1)/CB(2)-type receptor is targeted to axons, indicative of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling. Although CB(1)/CB(2)-type receptors are unique to chordates, enzymes involved in biosynthesis/inactivation of endocannabinoids occur throughout the animal kingdom. Accordingly, non-CB(1)/CB(2)-mediated mechanisms of endocannabinoid signalling have been postulated. For example, there is evidence that 2-AG mediates retrograde signalling at synapses in the nervous system of the leech Hirudo medicinalis by activating presynaptic transient receptor potential vanilloid-type ion channels. Thus, postsynaptic synthesis of 2-AG or anandamide may be a phylogenetically widespread phenomenon, and a variety of proteins may have evolved as presynaptic (or postsynaptic) receptors for endocannabinoids