76 research outputs found

    The Behaviour of the Irons and Copper of the Blood during Regeneration Following Anaemia

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    1. The literature pertaining to iron and copper metabolism has been reviewed. 2. It appears necessary that the serum iron and blood copper remain at, or above, their respective average normal levels for continued haemoglobin regeneration. 3. The present investigation suggests that copper has no effect upon the mobilisation of the stored iron in the body, but assists haemoglobin regeneration by aiding (a) the absorption of ferric iron from the intestine and (b) the conversion of serum iron into haemoglobin. 4. it is suggested that copper acts in the above two instances in the role of a catalyst

    Comparison between echocardiographic and non-ECG-gated CT measurements in dogs

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    The aim of this study was to compare echocardiographic measurements with non-ECG-gated contrast-enhanced cardiac CT measurements in dogs. Fifty-seven dogs were included in the study. The following echocardiographic parameters were measured: M-mode interventricular septum in diastole and systole, left ventricular internal diameter in diastole and systole, left ventricular free wall in diastole and systole, 2D left atrial maximal diameter, 2D left atrium to aorta ratio in diastole, 2D aortic annulus in systole and 2D pulmonary annulus in diastole and systole. CT measurements were obtained from multiplanar reconstruction images, replicating the imaging planes used for 2D measurements on echocardiography. It was not possible to discriminate between systole and diastole. The results showed moderate Lin's concordance correlation coefficients between the left ventricular internal diameter in systole (0.77), the aortic annuli (0.84) and the pulmonary annuli in diastole (0.78) and systole (0.80). Low coefficients were obtained between the other parameters. Bland-Altman plots for the parameters with highest concordance correlation coefficients were calculated. They suggested equivalence between the measurements of the aortic annuli. Equivalence was not seen between the remaining echocardiographic and CT measurements. Therefore, non-ECG-gated CT is not a reliable way of quantitatively assessing cardiac size

    Topological dynamics of an intrinsically disordered N-terminal domain of the human androgen receptor

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    ACKNOWLEDGEMENTS We are thankful to Eugene Shakhnovich (Harvard University) for critical reading of the manuscript, and to Peter Bolhuis and Ioana Ilie (University of Amsterdam) for technical discussions. The research in Mashaghi lab is supported by funding from Muscular Dystrophy Association (USA), Grant Number MDA628071, and Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) through NWA-IDG (NWA.1228.192.309) and Open Competition XS (OCENW.XS.076).Peer reviewedPublisher PD

    A comparison of the clinical effectiveness and cost of specialised individually-delivered parent training for preschool attention-deficit/hyperactivity disorder and a generic, group-based programme: a multi-centre, randomised controlled trial of the New Forest Parenting Programme versus Incredible Years

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    Objective: To compare the efficacy and cost of specialised individually-delivered parent training (PT) for preschool children with attention-deficit/ hyperactivity disorder (ADHD) against generic group-based PT and treatment as usual (TAU). Design: Multi-centre, three-arm parallel group randomised controlled trial. Research Setting: National Health Service Trusts. Participants: Preschool children (33-54 months) fulfilling ADHD research diagnostic criteria. Interventions: New Forest Parenting Programme (NFPP) – 12 week individual, home-delivered ADHD PT programme; Incredible Years (IY) – 12 week group-based, PT programme initially designed for children with behaviour problems. Main outcome measures: Primary outcome - Parent ratings of child’s ADHD symptoms (Swanson, Nolan & Pelham Questionnaire - SNAP-IV). Secondary outcomes - teacher ratings (SNAP-IV) and direct observations of ADHD symptoms and parent/teacher ratings of conduct problems. NFPP, IY and TAU outcomes were measured at baseline (T1) and post-treatment (T2). NFPP and IY outcomes only were measured 6 months post treatment (T3). Researchers, but not therapists or parents, were blind to treatment allocation. Analysis employed mixed effect regression models (multiple imputation). Intervention and other costs were estimated using standardized approaches. Results: NFPP and IY did not differ on parent-rated SNAP-IV, ADHD combined symptoms (mean difference -0.009 95%CI [-0.191, 0.173], p=0.921) or any other measure. Small, non-significant, benefits of NFPP over TAU were seen for parent-rated SNAP-IV, ADHD combined symptoms (-0.189 95%CI [-0.380, 0.003], p=0.053). NFPP significantly reduced parent-rated conduct-problems compared to TAU across scales (p-values.05). The cost per family of providing NFPP in the trial was significantly lower than IY (£1,591 versus £2,103). Conclusions: Although, there were no differences between NFPP and IY with regards clinical effectiveness, individually-delivered NFPP cost less. However, this difference may be reduced when implemented in routine clinical practice. Clinical decisions should take into account parental preferences between delivery approaches. Funding: National Institute of Health Research. Trial Registration: Trial name: COPPI Trial; ISRCTN39288126

    Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping

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