302 research outputs found

    Success Outcome Markers in Extension (SOME): Evaluating the Effects of Transformational Learning Programs

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    Success outcome markers (SOMs), and the process of creating them, offer Extension a new approach to plan, monitor, and evaluate programs. Generating success outcome markers helps to carefully determine all partners (including beneficiaries) who may need to change to accomplish program goals and identifies steps to continuously track incremental successes. Hard-to-measure human behaviors become more concrete when success outcome markers are listed. To successfully use SOMs, one must (a) create a vivid and compelling vision, (b) list your WHOs, (c) write an outcome challenge for each WHO, and (d) determine SOMs. Then decide how to monitor and report on each SOM

    Étude comparative du conte de Charles Perrault, « Le petit Chaperon rouge », en français et de deux traductions en espagnol. Problèmes de traduction et tendances constatées

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    La complejidad es seguramente lo que mejor define la traducción literaria en general y la traducción de la literatura infantil en concreto, de ahí la aparición de diversos trabajos de búsqueda sobre la teoría y la práctica de la traducción, que incluso han llevado al nacimiento de una nueva ciencia, la traductología. El cuento de Charles Perrault, “Le petit Chaperon rouge” (La Caperucita Roja), es el ejemplo mismo de una obra literaria para niños que ha dado la vuelta al mundo. Un análisis detallado de este cuento demuestra que es más complejo de lo que parece, tanto en la extensión de sus significados posibles, como en su expresión artística. La comparación del texto inicial de Charles Perrault publicado en 1697 con dos traducciones en español realizadas por Terodoro Baró en 1883 y por Leonardo Domingo en 2003 pondrá en evidencia las modificaciones realizadas que pueden explicarse especialmente por el contexto histórico o lingüístico de cada traductor. Comprobaremos asimismo que, si bien globalmente el relato de La Caperucita Roja es respectado, se pierde una parte de la complejidad del cuento por razones que debemos intentar explicar

    Biosynthesis of mycobacterial arabinogalactan: identification of a novel (13)arabinofuranosyltransferase

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    The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several anti-tubercular drugs. For instance, ethambutol targets arabinogalactan biosynthesis through inhibition of the arabinofuranosyltransferases Mt-EmbA and Mt-EmbB. A bioinformatics approach identified putative integral membrane proteins, MSMEG2785 in Mycobacterium smegmatis, Rv2673 in Mycobacterium tuberculosis and NCgl1822 in Corynebacterium glutamicum, with 10 predicted transmembrane domains and a glycosyltransferase motif (DDX), features that are common to the GT-C superfamily of glycosyltransferases. Deletion of M. smegmatis MSMEG2785 resulted in altered growth and glycosyl linkage analysis revealed the absence of AG (13)-linked arabinofuranosyl (Araf) residues. Complementation of the M. smegmatis deletion mutant was fully restored to a wild type phenotype by MSMEG2785 and Rv2673, and as a result, we have now termed this previously uncharacterized open reading frame, arabinofuranosyltransferase C (aftC). Enzyme assays using the sugar donor -D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) and a newly synthesized linear (15)-linked Ara5 neoglycolipid acceptor together with chemical identification of products formed, clearly identified AftC as a branching (13) arabinofuranosyltransferase. This newly discovered glycosyltransferase sheds further light on the complexities of Mycobacterium cell wall biosynthesis, such as in M. tuberculosis and related species and represents a potential new drug target

    Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant

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    Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM). Herein, we show by quantitative sugar and glycosyl linkage analysis that C. glutamicum possesses a much smaller LAM version, Cg-LAM, characterised by single t-Araf residues linked to th

    NF04-590 What is Guardianship?

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    This NebFact, the first in a series, discusses legal guardianship

    NF05-620 Guardianship/Conservatorship Financial Responsibilities

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    This NebFact, the fifth in a series, discusses legal guardianship and related financial responsibilities

    NF05-620 Guardianship/Conservatorship Financial Responsibilities

    Get PDF
    This NebFact, the fifth in a series, discusses legal guardianship and related financial responsibilities

    NF04-590 What is Guardianship?

    Get PDF
    This NebFact, the first in a series, discusses legal guardianship
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