1,059 research outputs found

    The structure of colloidosomes with tunable particle density: simulation vs experiment

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    Colloidosomes are created in the laboratory from a Pickering emulsion of water droplets in oil. The colloidosomes have approximately the same diameter and by choosing (hairy) particles of different diameters it is possible to control the particle density on the droplets. The experiment is performed at room temperature. The radial distribution function of the assembly of (primary) particles on the water droplet is measured in the laboratory and in a computer experiment of a fluid model of particles with pairwise interactions on the surface of a sphere.Comment: 16 pages, 2 tables, 7 figure

    Copolymerization of Styrene and Methyl Methacrylate in Ternary Oil-in-Water Microemulsions: Comments on a Paper by Gan et al

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    Exptl. data presented by L.M. Gan et al. are reinterpreted with the use of the error-in-variables method. The recalcd. reactivity ratios in microemulsion hardly deviate from earlier reported bulk copolymn. values. Furthermore it is shown that monomer sequence distribution as a function of copolymer compn. is equally well described by bulk reactivity ratios as it is by microemulsion reactivity ratios. This can easily be explained from the fact that the relation between monomer sequence distribution and copolymer compn. is governed by the reactivity ratio product, rather than by the sep. reactivity ratios. It is found that the reactivity ratio product in microemulsion does not significantly deviate from that in bul

    Sunday Driver links axonal transport to damage signaling

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    Neurons transmit long-range biochemical signals between cell bodies and distant axonal sites or termini. To test the hypothesis that signaling molecules are hitchhikers on axonal vesicles, we focused on the c-Jun NH2-terminal kinase (JNK) scaffolding protein Sunday Driver (syd), which has been proposed to link the molecular motor protein kinesin-1 to axonal vesicles. We found that syd and JNK3 are present on vesicular structures in axons, are transported in both the anterograde and retrograde axonal transport pathways, and interact with kinesin-I and the dynactin complex. Nerve injury induces local activation of JNK, primarily within axons, and activated JNK and syd are then transported primarily retrogradely. In axons, syd and activated JNK colocalize with p150Glued, a subunit of the dynactin complex, and with dynein. Finally, we found that injury induces an enhanced interaction between syd and dynactin. Thus, a mobile axonal JNK–syd complex may generate a transport-dependent axonal damage surveillance system

    A dynamical system approach to higher order gravity

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    The dynamical system approach has recently acquired great importance in the investigation on higher order theories of gravity. In this talk I review the main results and I give brief comments on the perspectives for further developments.Comment: 6 pages, 1 figure, 2 tables, talk given at IRGAC 2006, July 200

    Membrane binding proteins of coronaviruses

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    Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of severities. Their members include zoonotic viruses with pandemic potential where therapeutic options are currently limited. Despite this diversity CoVs share some common features including the production, in infected cells, of elaborate membrane structures. Membranes represent both an obstacle and aid to CoV replication – and in consequence – virus-encoded structural and nonstructural proteins have membrane-binding properties. The structural proteins encounter cellular membranes at both entry and exit of the virus while the nonstructural proteins reorganize cellular membranes to benefit virus replication. Here, the role of each protein in membrane binding is described to provide a comprehensive picture of their role in the CoV replication cycle
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