34,616 research outputs found

    Unknotting the Heart: Unemployment and Therapeutic Governance

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    [Excerpt] Since the mid-1990s, as China has downsized and privatized its state-owned enterprises, severe unemployment has created a new class of urban poor and widespread social and psychological disorders. In Unknotting the Heart, Jie Yang examines this understudied group of workers and their experiences of being laid off, counseled, and then reoriented to the market economy. Using fieldwork from reemployment programs, community psychosocial work, and psychotherapy training sessions in Beijing between 2002 and 2013, Yang highlights the role of psychology in state-led interventions to alleviate the effects of mass unemployment. She pays particular attention to those programs that train laid-off workers in basic psychology and then reemploy them as informal “counselors” in their capacity as housemaids and taxi drivers. These laid-off workers are filling a niche market created by both economic restructuring and the shortage of professional counselors in China, helping the government to defuse intensified class tension and present itself as a nurturing and kindly power. In reality, Yang argues, this process creates both new political complicity and new conflicts, often along gender lines. Women are forced to use the moral virtues and work ethics valued under the former socialist system, as well as their experiences of overcoming depression and suffering, as resources for their new psychological care work. Yang focuses on how the emotions, potentials, and “hearts” of these women have become sites of regulation, market expansion, and political imagination

    Optimal Actuator Location of the Minimum Norm Controls for Stochastic Heat Equations

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    In this paper, we study the approximate controllability for the stochastic heat equation over measurable sets, and the optimal actuator location of the minimum norm controls. We formulate a relaxed optimization problem for both actuator location and its corresponding minimum norm control into a two-person zero sum game problem and develop a sufficient and necessary condition for the optimal solution via Nash equilibrium. At last, we prove that the relaxed optimal solution is an optimal actuator location for the classical problem

    D-optimal Factorial Designs under Generalized Linear Models

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    Generalized linear models (GLMs) have been used widely for modelling the mean response both for discrete and continuous random variables with an emphasis on categorical response. Recently Yang, Mandal and Majumdar (2013) considered full factorial and fractional factorial locally D-optimal designs for binary response and two-level experimental factors. In this paper, we extend their results to a general setup with response belonging to a single-parameter exponential family and for multi-level predictors.Comment: 16 pages, 1 figur

    High temperature sensitivity is intrinsic to voltage-gated potassium channels.

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    Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous voltage-gated potassium (Kv) channels also exhibit high temperature sensitivity comparable to that of TRPV1, which is detectable under specific conditions when the voltage sensor is functionally decoupled from the activation gate through either intrinsic mechanisms or mutations. Interestingly, mutations could tune Shaker channel to be either heat-activated or heat-deactivated. Therefore, high temperature sensitivity is intrinsic to both TRP and Kv channels. Our findings suggest important physiological roles of heat-induced variation in Kv channel activities. Mechanistically our findings indicate that temperature-sensing TRP channels may not contain a specialized heat-sensor domain; instead, non-obligatory allosteric gating permits the intrinsic heat sensitivity to drive channel activation, allowing temperature-sensitive TRP channels to function as polymodal nociceptors

    Anomalous optical coupling between two silicon wires of a slot waveguide in epsilon-near-zero metamaterials

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    Anomalous optical coupling properties between two silicon wires in a silicon slot waveguide embedded in epsilon-near-zero (ENZ) metamaterials are proposed and demonstrated. The dependences of optical field enhancement in the slot region and transverse optical force on the slot size and the permittivity of surrounding material are studied in details. It is demonstrated that the optical field in the slot region is significantly enhanced due to the giant index contrast at the slot interface between silicon wires and ENZ metamaterials, but the optical mode coupling between silicon wires is greatly reduced so that the transverse optical force is suppressed into almost zero. Moreover, metal-dielectric multilayer structures are designed to realize ENZ metamaterials in the slot region for achieving the electric field enhancement.Comment: 14 pages, 5 figure

    Understand spiciness: mechanism of TRPV1 channel activation by capsaicin.

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    Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety of experimental techniques including mutagenesis, patch-clamp recording, crystallography, cryo-electron microscopy, computational docking and molecular dynamic simulation. A framework of how capsaicin binds and activates TRPV1 has started to merge: capsaicin binds to a pocket formed by the channel's transmembrane segments, where it takes a "tail-up, head-down" configuration. Binding is mediated by both hydrogen bonds and van der Waals interactions. Upon binding, capsaicin stabilizes the open state of TRPV1 by "pull-and-contact" with the S4-S5 linker. Understanding the ligand-host interaction will greatly facilitate pharmaceutical efforts to develop novel analgesics targeting TRPV1
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