4,161 research outputs found

    The Significance of the Haymarket Tragedy Then and Now

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    An example of spectral phase transition phenomenon in a class of Jacobi matrices with periodically modulated weights

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    We consider self-adjoint unbounded Jacobi matrices with diagonal q_n=n and weights \lambda_n=c_n n, where c_n is a 2-periodical sequence of real numbers. The parameter space is decomposed into several separate regions, where the spectrum is either purely absolutely continuous or discrete. This constitutes an example of the spectral phase transition of the first order. We study the lines where the spectral phase transition occurs, obtaining the following main result: either the interval (-\infty;1/2) or the interval (1/2;+\infty) is covered by the absolutely continuous spectrum, the remainder of the spectrum being pure point. The proof is based on finding asymptotics of generalized eigenvectors via the Birkhoff-Adams Theorem. We also consider the degenerate case, which constitutes yet another example of the spectral phase transition

    Mechanisms of RNA loading into exosomes

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    AbstractUpon fusion of multivesicular bodies (MVBs) with the plasma membrane, intraluminal vesicles (ILVs) are released into the extracellular space as exosomes. Since the lipid composition of the exosomal membrane resembles that of raft microdomains, the inward budding process involves the raft-like region of the MVB limiting membrane. Although published research suggests that cellular RNAs may be selectively sorted into exosomes, the molecular mechanisms remain elusive. In this review, we suggest that there is a continuous interaction of cellular RNAs with the outer (cytoplasmic) surface of MVBs and that the selection for incorporation of these RNAs into ILVs is based on their affinity to the raft-like region in the outer layer of the MVB membrane

    Local approximation of observables and commutator bounds

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    We discuss conditional expectations that can be used as generalizations of the partial trace for quantum systems with an infinite-dimensional Hilbert space of states

    Specific RNA binding to ordered phospholipid bilayers

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    We have studied RNA binding to vesicles bounded by ordered and disordered phospholipid membranes. A positive correlation exists between bilayer order and RNA affinity. In particular, structure-dependent RNA binding appears for rafted (liquid-ordered) domains in sphingomyelin-cholesterol-1,2-dioleoyl-sn-glycero-3-phosphocholine vesicles. Binding to more highly ordered gel phase membranes is stronger, but much less RNA structure-dependent. All modes of RNA-membrane association seem to be electrostatic and headgroup directed. Fluorometry on 1,2-dimyristoyl-sn-glycero-3-phosphocholine liposomes indicates that bound RNA broadens the gel-fluid melting transition, and reduces lipid headgroup order, as detected via fluorometric measurement of intramembrane electric fields. RNA preference for rafted lipid was visualized and confirmed using multiple fluorophores that allow fluorescence and fluorescence resonance energy transfer microscopy on RNA molecules closely associated with ordered lipid patches within giant vesicles. Accordingly, both RNA structure and membrane order could modulate biological RNA–membrane interactions
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