16 research outputs found

    Determining Bulk Factors for Three Subsoils Used in Forest Engineering in Slovenia

    Get PDF
    In Slovenia, torrent areas and forest roads are being regulated and built mostly in steep, erosion-prone areas. In addition to the geometry of extrapolated works, calculating bulk factors is key for estimating haulage masses. We have determined bulk factors for compact carbonate rock, mixed soil, and carbonate deposits. Each construction site was recorded with an unmanned aerial vehicle (UAV) before the excavation and after every 4Ā±2 m3 of excavated material. The average point cloud density was 9535 points/m2. We processed the point clouds from each construction site and determined the difference in volume between the volume of excavated area and the volume of deposited material. The average bulk factor for compact carbonate rock is 1.42, 1.20 for mixed soil and 1.15 for carbonate deposits (calculated for fully loaded eight-wheeled truck). The calculated bulk factors for soils and carbonate deposits match with the already established values, while the factor for compact rock is 20% lower than the factor currently in use by the Slovenian forest engineers

    Biomarkers for Huntingtonā€™s Disease

    Get PDF

    Distonija kao manifestacija korea-akantocitoze

    Get PDF
    The aim of this article is to present two Slovenian chorea-acanthocytosis (ChAc) siblings with an unusual predominantly dystonic ChAc phenotype. For diagnostic purposes, the genomic DNA was screened for VPS13A mutations. Movement disorder was evaluated and scored according to the Dystonia Movement and Disability Scale (DMDS) in order to evaluate the effects of L-dopa on dystonia. Brain imaging was performed with the use of magnetic resonance imaging scan and 99m Tc-ethyl cysteinate dimmer single photon emission computed tomography (Tc-ECD SPECT). Clinical neurological examination disclosed gait dystonia. Marked swallowing difficulty due to tongue and feeding dystonia was observed. Both siblings were found to be heterozygous for a substitution in exon 22 (c.2191C>T) and for a deletion in exon 35 (c.3995_3996delinsA) leading to mutation in VPS13A. After being administered L-dopa for three months, both subjects showed significant symptomatic improvement documented by reduced DMDS scores. It is concluded that VPS13A mutation testing may improve diagnosis of dystonia and recognition of atypical ChAc phenotypes. It seems that L-dopa could be effective in the treatment of dystonia due to VPS13A mutations.Prikazuje se dvoje slovenskih bolesnika, brat i sestra, s koreom-akantocitozom, s neuobičajenim pretežito distoničnim fenotipom korea-akantocitoze. Proveden je dijagnostički probir genomske DNA na mutacije VPS13A. Poremećaj kretanja procijenjen je i ocijenjen prema Dystonia Movement and Disability Scale (DMDS) kako bi se procijenili učinci L-dopa na distoniju. Slikovni prikazi mozga napravljeni su pomoću magnetske rezonance i Tc-ECD SPECT (99m Tc-ethyl cysteinate dimmer single photon emission computed tomography). Klinički neuroloÅ”ki pregled otkrio je distoniju hoda. Zapažene su znatne teÅ”koće pri gutanju zbog distonije jezika i distonija hranjenja. I brat i sestra bili su heterozigotni za supstituciju u eksonu 22 (c.2191C>T) i za deleciju u eksonu 35 (c.3995_3996delinsA), koje uzrokuju mutaciju u VPS13A. Nakon davanja L-dopa kroz tri mjeseca oboje je pokazalo značajno poboljÅ”anje simptoma, Å”to je dokumentirano sniženim zbirom na DMDS. Zaključuje se da testiranje na mutaciju VPS13A može pomoći u dijagnosticiranju distonije i prepoznavanju atipičnih fenotipova korea-akantocitoze. Čini se da bi L-dopa mogla biti učinkovita u liječenju distonije uzrokovane mutacijama VPS13A

    COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT

    Get PDF
    Background: In Huntington disease (HD) patients receiving rivastigmine treatment improvement of behavioral symptoms and of cognitive function (assessed with screening diagnostic instruments) has been reported. The aim of the present study was to verify such improvement in cognitive function by cognitive function assessment with a detailed neuropsychological battery covering all relevant cognitive systems expected to be impaired in early phase HD. Subjects and methods: Eighteen (18) HD patients entered the study and were randomly allocated to the rivastigmine and placebo group. All subjects underwent neuropsychological assessment at baseline. Follow-up neuropsychological assessment was applied after 6 months of rivastigmine or placebo treatment. Eighteen (18) healthy controls entered the study to control for practice effect and underwent neuropsychological assessment at baseline and after 6 months, without treatment. The neuropsychological battery consisted of assessment tools that are sensitive to cognitive impairment seen in early phase HD: CTMT, SDMT, Stroop (attention and information control), RFFT, TOL, Verbal fluency (executive functioning), CVLT-II, RCFT (learning and memory). Effect of rivastigmine and possible effect of practice was assessed using the mixed ANOVA model. Results: No statistically significant effect of rivastigmine treatment on cognitive function in HD patients was detected. There was no evidence for practice or placebo effect. Conclusions: Detailed neuropsychological assessment did not confirm previously reported effect of rivastigmine treatment on cognitive function in HD patients. The limitations of our study are, in particular, small sample size and the lack of a single measure of relevant cognitive functioning in HD patients. Instead of focusing solely on statistical significance, a clinical relevance study is proposed to clarify the issue of rivastigmine effects in HD

    Aging affects the phase coherence between spontaneous oscillations in brain oxygenation and neural activity

    Get PDF
    The risk of neurodegenerative disorders increases with age, due to reduced vascular nutrition and impaired neural function. However, the interactions between cardiovascular dynamics and neural activity, and how these interactions evolve in healthy aging, are not well understood. Here, the interactions are studied by assessment of the phase coherence between spontaneous oscillations in cerebral oxygenation measured by fNIRS, the electrical activity of the brain measured by EEG, and cardiovascular functions extracted from ECG and respiration effort, all simultaneously recorded. Signals measured at rest in 21 younger participants (31.1Ā±6.9 years) and 24 older participants (64.9Ā±6.9 years) were analysed by wavelet transform, wavelet phase coherence and ridge extraction for frequencies between 0.007 and 4 Hz. Coherence between the neural and oxygenation oscillations at āˆ¼0.1 Hz is significantly reduced in the older adults in 46/176 fNIRSEEG probe combinations. This reduction in coherence cannot be accounted for in terms of reduced power, thus indicating that neurovascular interactions change with age. The approach presented promises a noninvasive means of evaluating the efficiency of the neurovascular unit in aging and disease

    Determining bulk factors for three subsoils used in forest engineering in Slovenia

    Get PDF
    In Slovenia, torrent areas and forest roads are being regulated and built mostly in steep, erosion-prone areas. In addition to the geometry of extrapolated works, calculating bulk factors is key for estimating haulage masses. We have determined bulk factors for compact carbonate rock, mixed soil, and carbonate deposits. Each construction site was recorded with an unmanned aerial vehicle (UAV) before the excavation and after every 4Ā±2 m3 of excavated material. The average point cloud density was 9535 points/m2. We processed the point clouds from each construction site and determined the difference in volume between the volume of excavated area and the volume of deposited material. The average bulk factor for compact carbonate rock is 1.42, 1.20 for mixed soil and 1.15 for carbonate deposits (calculated for fully loaded eight-wheeled truck). The calculated bulk factors for soils and carbonate deposits match with the already established values, while the factor for compact rock is 20% lower than the factor currently in use by the Slovenian forest engineers

    Impact of forest structure on honey harvest in Slovenia

    Get PDF
    V lesni zalogi sestojev smo proučili vpliv količine medonosnih drevesnih vrst na donos medu. Za 70 čebeljih družin v Sloveniji smo uporabili podatke o donosih medu za posamezne drevesne vrste glede na čebelarsko najugodnejŔa leta in v radiju treh kilometrov od panja in izračunali: a) Ŕtevilo čebeljih družin (n), b) gozdnatost (%) ter c) skupno lesno zalogo medonosnih drevesnih vrst (m3 ). Vpliva Ŕtevila družin na donos medu v panj v večini primerov nismo potrdili (p > 0,05), statistično značilno pa vpliva na donos gozdnega in smrekovega medu. Delež gozda je v pozitivni korelaciji (r > 0,84p 0,05). The proportion of forest is in positive correlation (r > 0, p < 0,05) with the intake of forest honey in a beehive, same as the proportion of forest and spruce honey. For other species, the proportion of forest doesn%t affect honey income. According to the curves for tree species, we can predict honey income for forest stands in Slovenia

    COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT

    Get PDF
    Background: In Huntington disease (HD) patients receiving rivastigmine treatment improvement of behavioral symptoms and of cognitive function (assessed with screening diagnostic instruments) has been reported. The aim of the present study was to verify such improvement in cognitive function by cognitive function assessment with a detailed neuropsychological battery covering all relevant cognitive systems expected to be impaired in early phase HD. Subjects and methods: Eighteen (18) HD patients entered the study and were randomly allocated to the rivastigmine and placebo group. All subjects underwent neuropsychological assessment at baseline. Follow-up neuropsychological assessment was applied after 6 months of rivastigmine or placebo treatment. Eighteen (18) healthy controls entered the study to control for practice effect and underwent neuropsychological assessment at baseline and after 6 months, without treatment. The neuropsychological battery consisted of assessment tools that are sensitive to cognitive impairment seen in early phase HD: CTMT, SDMT, Stroop (attention and information control), RFFT, TOL, Verbal fluency (executive functioning), CVLT-II, RCFT (learning and memory). Effect of rivastigmine and possible effect of practice was assessed using the mixed ANOVA model. Results: No statistically significant effect of rivastigmine treatment on cognitive function in HD patients was detected. There was no evidence for practice or placebo effect. Conclusions: Detailed neuropsychological assessment did not confirm previously reported effect of rivastigmine treatment on cognitive function in HD patients. The limitations of our study are, in particular, small sample size and the lack of a single measure of relevant cognitive functioning in HD patients. Instead of focusing solely on statistical significance, a clinical relevance study is proposed to clarify the issue of rivastigmine effects in HD
    corecore