251 research outputs found
Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent
Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation reaction between chiral nucleophilic glycine derived Ni-complex and 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine has been developed under convenient conditions, which affords the corresponding alkylated Ni-complex in 74 % yield and excellent diastereoselectivity (only one isomer). This reaction features convenient conditions and completely controlled diastereoselectivity, which provides a highly valuable approach for asymmetric synthesis of 7-aza-tryptophan
Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice
Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal. However, orexin neurons produce and release orexin as well as several co-transmitters including dynorphin and glutamate. To disambiguate orexin-dependent and -independent physiological functions of orexin neurons, we generated a novel Orexin-flippase (Flp) knock-in mouse line. Crossing with Flp-reporter or Cre-expressing mice showed gene expression exclusively in orexin neurons. Histological studies confirmed that orexin was knock-out in homozygous mice. Orexin neurons without orexin showed altered electrophysiological properties, as well as received decreased glutamatergic inputs. Selective chemogenetic activation revealed that both orexin and co-transmitters functioned to increase wakefulness, however, orexin was indispensable to promote sustained arousal. Surprisingly, such activation increased the total time spent in cataplexy. Taken together, orexin is essential to maintain basic membrane properties and input-output computation of orexin neurons, as well as to exert awake-sustaining aptitude of orexin neurons
Metastable Vacua in Superconformal SQCD-like Theories
We study dynamical supersymmetry breaking in vector-like superconformal N=1
gauge theories. We find appropriate deformations of the superpotential to
overcome the problem of the instability of the non supersymmetric vacuum. The
request for long lifetime translates into constraints on the physical couplings
which in this regime can be controlled through efficient RG analysis.Comment: 17 pages, 7 figures, JHEP3.cl
O'KKLT at Finite Temperature
We study whether finite temperature corrections decompactify the internal
space in KKLT compactifications with an uplifting sector given by a system that
exhibits metastable dynamical supersymmetry breaking. More precisely, we
calculate the one-loop temperature corrections to the effective potential of
the volume modulus in the KKLT model coupled to the quantum corrected
O'Raifeartaigh model. We prove that for the original KKLT model, namely with
one exponent in the non-perturbative superpotential, the finite temperature
potential is runaway when at zero temperature there is a dS minimum. On the
other hand, for a non-perturbative superpotential of the race-track type with
two exponents, we demonstrate that the temperature-dependent part of the
effective potential can have local minima at finite field vevs. However, rather
unexpectedly, it turns out that these minima do not affect the structure of the
full effective potential and so the volume modulus is stabilized at the local
minimum of the zero temperature potential for the whole range of validity of
the supergravity approximation.Comment: 33 pages; minor corrections, journal versio
Superconductivity and crystalline electric field effects in the filled skutterudite series Pr(OsRu)Sb
X-ray powder diffraction, magnetic susceptibility , and electrical
resistivity measurements were made on single crystals of the filled
skutterudite series Pr(OsRu)Sb. One end of the series
() is a heavy fermion superconductor with a superconducting critical
temperature K, while the other end () is a conventional
superconductor with K. The lattice constant decreases
approximately linearly with increasing Ru concentration . As Ru (Os) is
substituted for Os (Ru), decreases nearly linearly with substituent
concentration and exhibits a minimum with a value of K at , suggesting that the two types of superconductivity compete with one
another. Crystalline electric field (CEF) effects in and
due to the splitting of the Pr nine-fold degenerate Hund's
rule multiplet are observed throughout the series, with the splitting
between the ground state and the first excited state increasing monotonically
as increases. The fits to the and data are
consistent with a doublet ground state for all values of x,
although reasonable fits can be obtained for a ground state for
values near the end member compounds ( or ).Comment: 10 pages, 8 figures, submitted to Phys. Rev.
A One-Scale Model of Dynamical Supersymmetry Breaking
A model of gauge-mediated supersymmetry breaking is constructed in which the
low-energy physics depends on a single dynamical scale. Strong coupling
dynamics of gauge theories plays an important role, in particular through its
effects on beta functions and through confinement. The model does not have
distinct messenger and supersymmetry-breaking sectors. The scale of
supersymmetry breaking is of order 10-100 \TeV, implying that the decay of the
next-to-lightest superpartner into the gravitino is prompt. Superoblique
corrections are enhanced. A Dirac fermion and one complex scalar, in a 10 or
\bar{10} of (global) SU(5), are predicted to be relatively light and to satisfy
certain mass relations with the standard model squarks and sleptons.Comment: 28 pages, uses revtex, h-physrev.bs
Plant responses to photoperiod
Photoperiod controls many developmental responses in animals, plants and even fungi. The response to photoperiod has evolved because daylength is a reliable indicator
of the time of year, enabling developmental events to be scheduled to coincide with particular environmental conditions. Much progress has been made towards
understanding the molecular mechanisms involved in the response to photoperiod in plants. These mechanisms include the detection of the light signal in the leaves,
the entrainment of circadian rhythms, and the production of a mobile signal which is transmitted throughout the plant. Flowering, tuberization and bud set are just a few of the many different responses in plants that are under photoperiodic control. Comparison of what is known of the molecular mechanisms controlling these responses shows that, whilst common components exist, significant differences in the regulatory mechanisms have evolved between these responses
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