6 research outputs found

    Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients

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    Hypophosphataemic Rickets Secondary to Raine Syndrome: A Review of the Literature and Case Reports of Three Paediatric Patients’ Dental Management

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    Raine Syndrome (RS) also referred to as lethal osteosclerotic bone dysplasia describes an exceptionally rare autosomal recessive disorder with an estimated prevalence of <1 in 1,000,000. Endocrinological manifestations such as hypophosphataemic rickets depict a recent finding within the phenotypic spectrum of nonlethal RS. The dental sequelae of hypophosphataemic rickets are significant. Spontaneous recurrent abscesses on noncarious teeth result in significant odontogenic pain and multiple dental interventions. The dental presentations of nonlethal RS are less widely described within the literature. Amelogenesis Imperfecta (AI), however, was recently postulated as a key characteristic. This article presents the dental manifestations and extensive restorative and oral surgical intervention of three siblings with hypophosphataemic rickets secondary to Raine Syndrome treated at Great Ormond Street Hospital for Children, a tertiary referral hospital

    Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma

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    Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known to be related to human diseases. Systemic sequelae of MSD are vast and multisystemic, primarily encompassing developmental delay and neurological, cardiopulmonary, dermatological, gastroenterological, and skeletal manifestations. The dental phenotype is scarcely described in the literature due to a paucity of cases. Dental treatment under local and general anaesthesia mandates an integrated multidisciplinary approach to safeguard systemic health and optimise outcomes. This paper presents two siblings with multiple sulfatase deficiency who presented to the Paediatric Dental Department at Great Ormond Street Hospital, requiring comprehensive care under general anaesthesia for dental caries and trauma

    The prevalence of and factors influencing statistical testing of baseline characteristics in randomized controlled trials published in high-impact orthodontic journals.

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    INTRODUCTION When proper randomization has been undertaken, statistical testing of baseline characteristics between participants in trial arms in randomized controlled trials (RCTs) is not required. This investigation aimed to assess the prevalence of statistical testing of baseline differences in orthodontic RCTs. Factors influencing the undertaking of this analysis were explored. METHODS Orthodontic RCTs published between January 1, 2017 and December 31, 2021 in 5 orthodontic journals were identified. To determine if statistical testing of baseline differences had been undertaken, each article was reviewed in detail to identify the reporting of P values and the term "significant difference" in the table of characteristics, the table legends, and the results section of each included RCT. Trial characteristics at the RCT level were extracted. Frequency distributions were calculated for the included trial characteristics. Significant predictors from the univariate analysis were used to construct a multivariable Bayesian logistic regression model. RESULTS One hundred and thirty-two RCTs were analyzed. Significance testing of baseline characteristics was undertaken in 50% (66/132) of RCTs. At a journal level, significance testing at baseline was infrequently undertaken in RCTs published in the American Journal of Orthodontics and Dentofacial Orthopedics (AJODO). Compared with 2017, RCTs published in 2018 (odds ratio [OR], 5.57; 95% credible interval [CrI], 1.33-25.69), 2019 (OR, 17.82; 95% CrI, 4.41-82.11), 2020 (OR, 6.48; 95% CrI, 1.72-27.12), and 2021 (OR, 3.24, 95% CrI, 0.81-14.01) had higher odds of significance testing at baseline. RCTs published in the European Journal of Orthodontics (OR, 5.31; 95% CrI, 1.79-17.04), Progress in Orthodontics (OR, 5.00; 95% CrI, 0.97-28.43), Orthodontics and Craniofacial Research (OR, 6.49; 95% CrI, 1.04-46.10), and Angle Orthodontist (OR, 12.30; 95% CrI, 3.27-51.44) had higher odds of significant testing at baseline testing compared with AJODO. CONCLUSIONS Statistical testing of baseline differences is common in orthodontic RCTs. Trials published in AJODO had the lowest incidence of statistical testing of baseline differences. RCTs published between 2018-2021 had higher odds of significance testing at baseline than in 2017. Per the consolidated standards of reporting trials guidelines, this practice should be discouraged as it can be misleading and unnecessary

    Assessing the Energy-Efficiency Gap

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