11 research outputs found

    EVALUATION OF KNEE FLEXORS AND EXTENSORS MUSCLE STRENGTH AFTER LIGAMENTOPLASTY FOR ANTERIOR CRUCIATE LIGAMENT AFTER 6 MONTHS OF SURGERY

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    The alteration of the strength of the quadriceps and hamstrings after six months of reconstruction of the anterior cruciate ligament (ACL) induces a decrease in performance and can cause injury. Hypothesis: The muscular strength of the operated side of anterior cruciate ligament after 6 months of surgery shows some muscular weakness in the quadriceps and hamstrings in comparison with the healthy side. Motor performance will be dependent on the total recovery of muscle strength of these young athletes. Purpose: This study evaluated the isokinetic muscle strength parameters after 6 months of anterior cruciate ligament rehabilitation in young athletes. Methods: We measured muscle strength of 50 patients, 6 months after surgery after ACL reconstruction. The parameters used to evaluate the strength of the quadriceps and hamstrings were the: peak torque, average power, total work, max repetition total work and the ratio agonist / antagonist (AGO/ANTAG). They were studied at various speeds: 120, 180.300 degrees / sec. Results: muscle strength in the operated side after 6 months of conservative treatment shows a deficit only at the level of the quadriceps muscle in comparison with the healthy side. Conclusion: hamstrings are recovered more quickly than the quadriceps

    ROLE OF CUTANEOUS AFFERENTS IN THE CONTROL OF FINE MOVEMENTS

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    An increase in the quantity of afferents has been observed to be less useful to normal individual, therefore to patients suffering from neurological problems. To determine the effect of reduction of cutaneous afferents in the control of fine movements.Sixty healthy individuals, age between 20 and 25 years, were randomized into 2 groups.Main outcome measures: The speed of movements was measured with a specific device constructed specially to this study, related to digital chronometer that detects 1/100 of the second. T-test was performed for outcome measure and to evaluate individual difference within groups in the presence of significance. The position at the edge of the support show an increase in the speed of the fine movement by 82% than the position completely on the support

    ROLE OF CUTANEOUS AFFERENTS IN THE CONTROL OF FINE MOVEMENTS

    Get PDF
    An increase in the quantity of afferents has been observed to be less useful to normal individual, therefore to patients suffering from neurological problems. To determine the effect of reduction of cutaneous afferents in the control of fine movements.Sixty healthy individuals, age between 20 and 25 years, were randomized into 2 groups.Main outcome measures: The speed of movements was measured with a specific device constructed specially to this study, related to digital chronometer that detects 1/100 of the second. T-test was performed for outcome measure and to evaluate individual difference within groups in the presence of significance. The position at the edge of the support show an increase in the speed of the fine movement by 82% than the position completely on the support

    COMPARATIVE TOXICITY STUDY OF CHLOROQUINE AND HYDROXYCHLOROQUINE ON ADULT ALBINO RATS

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    Expanded use of Chloroquine and hydroxychloroquine drugs for non-malarial disease entities has resulted in prolonged duration of therapy and higher daily dosages leading to cumulative doses greater than those used in antimalarial therapy. The aim of the study is to evaluate and compare the toxic effects of chloroquine and hydroxychloroquine on different organs of albino rats. The study was conducted on 60 normal albino rats divided into 3 groups, the 1st group is the control group that received only distilled water, the 2nd and the 3rd group were given a single daily oral doses equivalent to 1/10th of LD50 chloroquine and hydroxychloroquine respectively. Assessment of liver and kidney functions, and histopathological changes in liver, kidney, and heart in different groups was done. The chloroquine treated group showed significant elevation of serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin (TB), serum creatinine-urea (Cr-U), Creatine Kinase-MB, C-reactive protein and Malonic dialdehyde levels as compared to control and hydroxychloroquine treated group. The histopathological evaluation showed marked hydropic degeneragtion, vascular congestion, interstitial hemorrhage, and necrosis in the liver, kidney and heart of chloroquine treated group, while hydroxychloroquine treated group showed mild congestion and slight cellular degeneration. Thus, hydroxychloroquine is less toxic and physicians should prescribe it better than chloroquine. Chloroquine if prescribed for therapeutic uses should be taken for short periods

    Morphometric study of the lumbosacral spine and some of its related angles in Lebanese adult females

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    The present study was undertaken to examine the morphometric characteristics of lumbar vertebrae, lumbar intervertebral discs and some important related angles in Lebanese adult females. The subjects of this study were thirty Lebanese adult females aged between 18-22 years. The subjects were selected among students of the faculty of health sciences, Beirut Arab University. Two plain radiographic views for the lumbosacral spine were taken for each subject, an anteroposterior view and a lateral view. Measurements were made directly on the X-ray films using Vernier calliper and were recorded to the nearest tenth of a millimetre. The following measurements were taken for each lumbar vertebra: the anterior height of the body, the posterior height of the body, the horizontal diameter of the pedicle, the vertical diameter of the pedicle, the interpedicular distance, the width (transverse diameter) of the body. Also the anterior height, the posterior height and the anteroposterior diameter (disc depth) of the intervertebral disc were measured. In addition, the following angles were measured: the angle of lumbar lordosis, the lumbosacral angle and the angle of sacral inclination. The mean and standard deviation were calculated and recorded. The results offer a base line reference for normal Lebanese adult females and a guidance to clinicians for the evaluation and management of subjects complaining of low back pain, in order to propose specific preventive or rehabilitation protocols to prevent low back pain as a function of spinal alignment. Moreover, these normal figures could also be of forensic importance because of the observed racial, ethnic and regional variations

    VALPROIC ACID INDUCES APOPTOSIS AND INCREASES CXCR7 EXPRESSION IN EPITHELIAL OVARIAN CANCER CELL LINE SKOV-3.

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    Background: The chemokine receptor, CXCR7 is described to play a biologically relevant role in tumor growth and spread. Recently, it was reported that CXCR7 overexpression is associated with an unfavorable prognosis and metastatis of epithelial ovarian cancer (EOC). Aware that, several reports indicated that Histone deacetylases (HDACs) regulate the expression and activity of many proteins involved in both cancer initiation and progression, the aim of this work, was to study the effect of the HDAC inhibitor valproic acid (VPA) on the expression of CXCR7 as well as its impact on survival function in the epithelial ovarian cell line (SKOV-3). Methods: cells were cultured with varying concentrations of VPA (1, 2, 3, 4, 5 and 10 mM) for different durations (0, 12 h, 24 h and 48 h). Cell survival was assessed by Neutral red assay and by colony counting which being stained with crystal violet. CXCR7 expression was determined at mRNA level using quantitative real-time PCR (qRT-PCR) or at the protein level using western blotting. Results: VPA reduces cell survival of SKOV-3 cancer cells. The inhibition effect of VPA was dose and time-dependent. Exposure to VPA at concentrations above 2 mM at 24 h resulted in an increase expression of CXCR7 at both the mRNA and protein levels . Conclusion: These observations provide, for the first time, a better insight into the epigenetic mechanisms involved in regulating CXCR7 expression in EOC and will open new avenues for evaluating drugs that specifically stimulate the apoptosis of EOC with minimal unwanted side effect

    VALPROIC ACID INDUCES APOPTOSIS AND INCREASES CXCR7 EXPRESSION IN EPITHELIAL OVARIAN CANCER CELL LINE SKOV-3.

    Get PDF
    Background: The chemokine receptor, CXCR7 is described to play a biologically relevant role in tumor growth and spread. Recently, it was reported that CXCR7 overexpression is associated with an unfavorable prognosis and metastatis of epithelial ovarian cancer (EOC). Aware that, several reports indicated that Histone deacetylases (HDACs) regulate the expression and activity of many proteins involved in both cancer initiation and progression, the aim of this work, was to study the effect of the HDAC inhibitor valproic acid (VPA) on the expression of CXCR7 as well as its impact on survival function in the epithelial ovarian cell line (SKOV-3). Methods: cells were cultured with varying concentrations of VPA (1, 2, 3, 4, 5 and 10 mM) for different durations (0, 12 h, 24 h and 48 h). Cell survival was assessed by Neutral red assay and by colony counting which being stained with crystal violet. CXCR7 expression was determined at mRNA level using quantitative real-time PCR (qRT-PCR) or at the protein level using western blotting. Results: VPA reduces cell survival of SKOV-3 cancer cells. The inhibition effect of VPA was dose and time-dependent. Exposure to VPA at concentrations above 2 mM at 24 h resulted in an increase expression of CXCR7 at both the mRNA and protein levels . Conclusion: These observations provide, for the first time, a better insight into the epigenetic mechanisms involved in regulating CXCR7 expression in EOC and will open new avenues for evaluating drugs that specifically stimulate the apoptosis of EOC with minimal unwanted side effect
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