271 research outputs found

    New Developments in Planning Accelerated Life Tests

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    Accelerated life tests (ALTs) are often used to make timely assessments of the life time distribution of materials and components. The goal of many ALTs is estimation of a quantile of a log-location failure time distribution. Much of the previous work on planning accelerated life tests has focused on deriving test-planning methods under a specific log-location distribution. This thesis presents a new approach for computing approximate large-sample variances of maximum likelihood estimators of a quantile of general log-location distribution with censoring and time-varying stress based on a cumulative exposure model. This thesis also presents a strategy to develop useful test plans using a small number of test units. We provide an approach to find optimum step-stress accelerated life test plans by using the large-sample approximate variance of the maximum likelihood estimator of a quantile of the failure time distribution at use conditions from a step-stress accelerated life test. In Chapter 2, we show this approach allows for multi-step stress changes and censoring for general log-location-scale distributions. As an application of this approach, the optimum variance is studied as a function of shape parameter for both Weibull and lognormal distributions. Graphical comparisons among test plans using step-up, step-down, and constant-stress patterns are also presented. The results show that, depending on the values of the model parameters and quantile of interest, each of the three test plans can be preferable in terms of optimum variance. In Chapter 3, using sample data from a published paper describing optimum ramp-stress test plans, we show that our approach and the one used in the previous work give the same variance-covariance matrix of the quantile estimator from the two different approaches. Then, as an application of this approach, we extend the previous work to a new optimum ramp-stress test plan obtained by simultaneously adjusting the ramp rate and the lower start level of stress. We find that the new optimum test plan can have smaller variances than that of the optimum ramp-stress test plan previously obtained by adjusting only the ramp rate. We also compare optimum ramp-stress test plans with the more commonly used constant-stress accelerated life test plans. Previous work on planning accelerated life tests has been based on large-sample approximations to evaluate test plan properties. In Chapter 4, we use more accurate simulation methods to investigate the properties of accelerated life tests with small sample sizes where large-sample approximations might not be expected to be adequate. These properties include the simulated bias and variance for quantiles of the failure-time distribution at use conditions. We focus on using these methods to find practical compromise test plans that use three levels of stress. We also study the effects of not having any failures at test conditions and the effect of using incorrect planning values. We note that the large-sample approximate variance is far from adequate when the probability of zero failures at certain test conditions is not negligible. We suggest a strategy to develop useful test plans using a small number of test units while meeting constraints on the estimation precision and on the probability that there will be zero failures at one or more of the test stress levels

    A Brief Discussion on Construction Quality Control of Building Tall Template

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    At present, China's construction industry is being launched along with the rapid development of urbanization, the building in functionality are becoming more complex, a growing number of high-rise buildings. Tall template in today’s construction work has been widely recognized and applied. High quality construction template has a very large impact on the overall quality and safety of the project, so the quality of the construction of up to template control. In this paper, building construction quality control measures were analyzed to provide a reference for the industry

    Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

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    Insulin resistance is the undisputed root cause of type 2 diabetes mellitus (T2DM). There is currently an unmet demand for safe and effective insulin sensitizers, owing to the restricted prescription or removal from market of certain approved insulin sensitizers, such as thiazolidinediones (TZDs), because of safety concerns. Effective insulin sensitizers without TZD-like side effects will therefore be invaluable to diabetic patients. The specific focus on peroxisome proliferator-activated receptor γ- (PPARγ-) based agents in the past decades may have impeded the search for novel and safer insulin sensitizers. This review discusses possible directions and promising strategies for future research and development of novel insulin sensitizers and describes the potential targets of these agents. Direct PPARγ agonists, selective PPARγ modulators (sPPARγMs), PPARγ-sparing compounds (including ligands of the mitochondrial target of TZDs), agents that target the downstream effectors of PPARγ, along with agents, such as heat shock protein (HSP) inducers, 5′-adenosine monophosphate-activated protein kinase (AMPK) activators, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) selective inhibitors, biguanides, and chloroquines, which may be safer than traditional TZDs, have been described. This minireview thus aims to provide fresh perspectives for the development of a new generation of safe insulin sensitizers

    A Tool for Evaluating Time-Varying-Stress Accelerated Life Test Plans With Log-Location-Scale Distributions

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    Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease

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    BackgroundThe relationship between human serum albumin levels and the prognosis of critical care patients with chronic obstructive pulmonary disease (COPD) remains controversial.ObjectiveTo investigate the relationship between serum albumin levels and in-hospital mortality in critical care patients with COPD. METHODS: This study used a retrospective observational cohort from the Medical Information in Intensive Care database (MIMIC-IV) in the United States. Multivariate Cox regression analysis was used to assess the relationship between serum albumin levels and in-hospital mortality. A restricted cubic spline line was also used to explore nonlinear relationship.ResultsA total of 3,398 critical care patients with COPD were included. The overall in-hospital mortality was 12.4%. We found a negative relationship between human serum albumin and in-hospital mortality (HR = 0.97, 95% CI 0.96–0.99, p = 0.002).ConclusionIn critical care patients with COPD, there was a negative association between human serum albumin and in-hospital mortality

    Identification of Cathepsin K in the Peritoneal Metastasis of Ovarian Carcinoma Using In-silico, Gene Expression Analysis

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    Abstract Ovarian carcinomas (OC) are often found in the advanced stage with wide peritoneal dissemination. Differentially-expressed genes (DEGs) between primary ovarian carcinoma (POC) and peritoneal metastatic ovarian carcinomas (PMOC) may have diagnostic and therapeutic values. In this study, we identified 246 DEGs by in-silico analysis using microarrays for 153 POCs and 57 PMOCs. Pathway analysis shows that many of these genes are associated with lipid metabolism. Microfluidic, card-based, quantitative PCR validated 19 DEGs in PMOCs versus POCs (p<0.05). Immunohistochemistry confirmed overexpression of MMP13, CTSK, FGF1 and GREM1 in PMOCs (p<0.05). ELISA detection indicated that serum CTSK levels were significantly increased in OCs versus controls (p<0.001). CTSK levels discriminated between OCs and healthy controls (ROC 0.739;. Combining CA125 and HE4 with CTSK levels produced an improved specificity in the predictive of OCs (sensitivity 88.3%, specificity 92.0%, Youden's index 80.3%). Our study suggests that CTSK levels may be helpful in the diagnosis of primary, ovarian carcinoma
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