251,780 research outputs found

    Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria:A Multicentric North American Experience

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    Objective: To evaluate long-term oncologic outcomes of patients post-living donor liver transplantation (LDLT) within and outside standard transplantation selection criteria and the added value of the incorporation of the New York-California (NYCA) score. Background: LDLT offers an opportunity to decrease the liver transplantation waitlist, reduce waitlist mortality, and expand selection criteria for patients with hepatocellular carcinoma (HCC). Methods: Primary adult LDLT recipients between October 1999 and August 2019 were identified from a multicenter cohort of 12 North American centers. Posttransplantation and recurrence-free survival were evaluated using the Kaplan-Meier method. Results: Three hundred sixty LDLTs were identified. Patients within Milan criteria (MC) at transplantation had a 1, 5, and 10-year posttransplantation survival of 90.9%, 78.5%, and 64.1% versus outside MC 90.4%, 68.6%, and 57.7% (P = 0.20), respectively. For patients within the University of California San Francisco (UCSF) criteria, respective posttransplantation survival was 90.6%, 77.8%, and 65.0%, versus outside UCSF 92.1%, 63.8%, and 45.8% (P = 0.08). Fifty-three (83%) patients classified as outside MC at transplantation would have been classified as either low or acceptable risk with the NYCA score. These patients had a 5-year overall survival of 72.2%. Similarly, 28(80%) patients classified as outside UCSF at transplantation would have been classified as a low or acceptable risk with a 5-year overall survival of 65.3%. Conclusions: Long-term survival is excellent for patients with HCC undergoing LDLT within and outside selection criteria, exceeding the minimum recommended 5-year rate of 60% proposed by consensus guidelines. The NYCA categorization offers insight into identifying a substantial proportion of patients with HCC outside the MC and the UCSF criteria who still achieve similar post-LDLT outcomes as patients within the criteria.</p

    Observation of enhanced long-range elliptic anisotropies inside high-multiplicity jets in pp collisions at s\sqrt{s} = 13 TeV

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    International audienceA search for partonic collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged constituents using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of s\sqrt{s} = 13 TeV, corresponding to an integrated luminosity of 138 fb1^{-1}. Jets are reconstructed with the anti-kTk_\mathrm{T} algorithm with a distance parameter of 0.8 and are required to have transverse momentum greater than 550 GeV and pseudorapidity η\lvert\eta\rvert<\lt 1.6. Two-particle correlations among the charged constituents within the jets are studied as functions of the particles' azimuthal angle and pseudorapidity separations (Δϕ\Delta\phi^* and Δη\Delta\eta^*) in a jet coordinate basis, where constituents' η\eta^*, ϕ\phi^* are defined relative to the direction of the jet. The correlation functions are studied in classes of in-jet charged-particle multiplicity up to NchjN_\text{ch}^\mathrm{j}\approx 100. Fourier harmonics are extracted from long-range azimuthal correlation functions to characterize azimuthal anisotropy for Δη\lvert\Delta\eta^*\rvert>\gt 2. For low-multiplicity jets, the long-range elliptic anisotropic harmonic, v2v^*_2, is observed to decrease with NchjN_\text{ch}^\mathrm{j}. This trend is well described by Monte Carlo event generators. However, a rising trend for v2v^*_2 emerges at NchjN_\text{ch}^\mathrm{j}\gtrsim 80, hinting at a possible onset of collective behavior, which is not reproduced by the models tested. This observation yields new insights into the dynamics of parton fragmentation processes in the vacuum

    Identified charged-hadron production in pp++Al, 3^3He++Au, and Cu++Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV and in U++U collisions at sNN=193\sqrt{s_{_{NN}}}=193 GeV

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    International audienceThe PHENIX experiment has performed a systematic study of identified charged-hadron (π±\pi^\pm, K±K^\pm, pp, pˉ\bar{p}) production at midrapidity in pp++Al, 3^3He++Au, Cu++Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV and U++U collisions at sNN=193\sqrt{s_{_{NN}}}=193 GeV. Identified charged-hadron invariant transverse-momentum (pTp_T) and transverse-mass (mTm_T) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle ratios of K/πK/\pi and p/πp/\pi have been measured in different centrality ranges of large (Cu++Au, U++U) and small (pp++Al, 3^3He++Au) collision systems. The values of K/πK/\pi ratios measured in all considered collision systems were found to be consistent with those measured in pp++pp collisions. However the values of p/πp/\pi ratios measured in large collision systems reach the values of 0.6\approx0.6, which is 2\approx2 times larger than in pp++pp collisions. These results can be qualitatively understood in terms of the baryon enhancement expected from hadronization by recombination. Identified charged-hadron nuclear-modification factors (RABR_{AB}) are also presented. Enhancement of proton RABR_{AB} values over meson RABR_{AB} values was observed in central 3^3He++Au, Cu++Au, and U++U collisions. The proton RABR_{AB} values measured in pp++Al collision system were found to be consistent with RABR_{AB} values of ϕ\phi, π±\pi^\pm, K±K^\pm, and π0\pi^0 mesons, which may indicate that the size of the system produced in pp++Al collisions is too small for recombination to cause a noticeable increase in proton production

    Test of lepton flavor universality in B±^{\pm}\to K±μ+μ^{\pm}\mu^+\mu^- and B±^{\pm}\to K±^{\pm}e+^+e^- decays in proton-proton collisions at s\sqrt{s} = 13 TeV