Une enquête plus approfondie sur l'impression 3D et de numérisation 3D dans les bibliothèques de l'Université Dalhousie

Alors qu’on observe un intérêt grandissant des bibliothèques dans la numérisation de leurs ouvrages, la digitalisation des collections d’œuvres physiques réunissant les œuvres d’art, les textiles ou autres reliques à forte valeur historique est toujours à l’état embryonnaire. En revanche, les progrès en termes de technologies de scanner 3D ont facilité la numérisation des tels objets physiques, et le développement des technologies de reproduction d’image 3D et d’holographie a fourni une nouvelle façon pour les bibliothèques de mettre ces informations à dispositions de leurs utilisateurs dans le monde entier. Le rapport détaillera comment cette technologie a permis de mettre des modèles d’image 3D au service de toute personne en manifestant le besoin, et exposera les difficultés rencontrées dans sa mise en place, la manière dont le service est utilisé et finalement en quoi globalement, ce service a été une réussite

The Motivated Partisan: A Dual Motivations Theory of Partisan Change and Stability.

Is party identification highly stable or regularly updated? Is party identification an impediment to democratic accountability or a helpful shortcut? Political scientists have debated the answers to these questions for fifty years. This dissertation incorporates intuition from both of the two dominant camps in this debate, arguing that partisan dynamics are shaped by competing motives. This theory is tested through a series of four original experiments and analysis of survey data from the American National Election Studies. By bringing partisans’ attitudes and party identities into conflict with one another, I am able to observe the methods that partisans use to reconcile their motives and defend their identities. By inhibiting partisans’ ability to deploy these defenses, I am able to induce party identification change among the most vulnerable partisans. Through a survey experiment, I observe how salient political evaluations can create identity pressure during surveys and how respondents go about resolving this pressure. Finally, by priming instrumental concerns versus expressive concerns, the motivational underpinnings of partisan responsiveness are clarified. Specifically, party identification change results from the desire to appear pragmatic—a norm of civic duty—and not from the drive to attain policy benefits. Implications for partisan dynamics, the responsiveness of the electorate, and our understanding of democratic accountability are discussed.Ph.D.Political ScienceUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/64587/1/egroenen_1.pd

A novel patient engagement platform using accessible text messages and calls (Epharmix): Feasibility study

BACKGROUND: Patient noncompliance with therapy, treatments, and appointments represents a significant barrier to improving health care delivery and reducing the cost of care. One method to improve therapeutic adherence is to improve feedback loops in getting clinically acute events and issues to the relevant clinical providers as necessary (ranging from detecting hypoglycemic events for patients with diabetes to notifying the provider when patients are out of medications). Patients often don\u27t know which information should prompt a call to their physician and proactive checks by the clinics themselves can be very resource intensive. We hypothesized that a two-way SMS system combined with a platform web service for providers would enable both high patient engagement but also the ability to detect relevant clinical alerts. OBJECTIVE: The objectives of this study are to develop a feasible two-way automated SMS/phone call + web service platform for patient-provider communication, and then study the feasibility and acceptability of the Epharmix platform. First, we report utilization rates over the course of the first 18 months of operation including total identified clinically significant events, and second, review results of patient user-satisfaction surveys for interventions for patients with diabetes, COPD, congestive heart failure, hypertension, surgical site infections, and breastfeeding difficulties. METHODS: To test this question, we developed a web service + SMS/phone infrastructure ( Epharmix ). Utilization results were measured based on the total number of text messages or calls sent and received, with percentage engagement defined as a patient responding to a text message at least once in a given week, including the number of clinically significant alerts generated. User satisfaction surveys were sent once per month over the 18 months to measure satisfaction with the system, frequency and degree of communication. Descriptive statistics were used to describe the above information. RESULTS: In total, 28,386 text messages and 24,017 calls were sent to 929 patients over 9 months. Patients responded to 80% to 90% of messages allowing the system to detect 1164 clinically significant events. Patients reported increased satisfaction and communication with their provider. Epharmix increased the number of patient-provider interactions to over 10 on average in any given month for patients with diabetes, COPD, congestive heart failure, hypertension, surgical site infections, and breastfeeding difficulties. CONCLUSIONS: Engaging high-risk patients remains a difficult process that may be improved through novel, digital health interventions. The Epharmix platform enables increased patient engagement with very low risk to improve clinical outcomes. We demonstrated that engagement among high-risk populations is possible when health care comes conveniently to where they are

UPR Signal Activation by Luminal Sensor Domains

The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling. © 2013 by the authors; licensee MDPI, Basel, Switzerland

Unreflective Partisans? Policy Information and Evaluation in the Development of Partisanship

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/1/pops12480.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/2/pops12480-sup-0002-suppinfo2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/3/pops12480-sup-0001-suppinfo1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142526/4/pops12480_am.pd

Coparenting after marital dissolution and children's mental health: a systematic review

Research has shown that coparenting is a vital family mechanism in predicting mental health in children and adolescents. Considering the increasing prevalence of marital dissolution in Western societies, the objective of this systematic review was to summarize the key results of empirical studies that tested the association between mental health of children and coparenting after marital dissolution.info:eu-repo/semantics/publishedVersio

Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms

Previously we found that terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. In this report, focusing our attention on the apoptotic mechanisms activated by terfenadine, we show that this drug can potentially activate distinct intrinsic signaling pathways depending on culture conditions. Serum-deprived conditions enhance the cytotoxic effect of terfenadine and caspase-4 and -2 are activated upstream of caspase-9. Moreover, although we found an increase in ROS levels, the apoptosis was ROS independent. Conversely, terfenadine treatment in complete medium induced ROS-dependent apoptosis. Caspase-4, -2, and -9 were simultaneously activated and p73 and Noxa induction were involved. ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells. Finally, we found that terfenadine induced autophagy, that can promote apoptosis. These findings demonstrate the great potential of terfenadine to kill melanoma cells through different cellular signaling pathways and could contribute to define new therapeutic strategies in melanoma