5,184 research outputs found

    Bad Berka Apotheke

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    Historical questionnaire/s 1924/1948 and index cards, partly selected enclosures regarding the history of a German pharmacy, catalogued via Kalliope portal (Historischer Fragebogen 1924/1948 und Karteikarten, ggf. gemeinfreie Anlagen zur Apothekengeschichte; als Katalog dient das Nachlassportal Kalliope): https://kalliope-verbund.info/ead?ead.id=DE-611-BF-70963 Please note: The Kalliope catalogue entry might indicate related material in the archival folder which cannot be published due to copyright or other legal restrictions (NB: Das Katalogisat bei Kalliope kann auch auf Materialien - teils erheblichen Umfangs - verweisen, die aus archiv- oder urheberrechtlichen Gründen nicht veröffentlicht werden dürfen)

    Case report: Strong low-density-cholesterol reduction accompanied by shrinkage of low-attenuation coronary plaque during lipid-lowering treatment with bempedoic acid—serial evaluation by coronary computed tomography angiography

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    Here, we present a patient with coronary artery disease and prior percutaneous coronary interventions. This patient had to discontinue taking multiple statins and ezetimibe due to intolerance with musculoskeletal complaints and nausea. Monotherapy with bempedoic acid was well tolerated and was exceptionally effective at lipid lowering, enabling patients to achieve the low-density lipoprotein target of <55 mg/dl, as recommended by current guidelines. In addition, serial coronary computed tomography angiography performed upon clinical indications, during 20 months of lipid-lowering treatment with bempedoic acid, demonstrated signs of favorable plaque component modification, with shrinkage of the low-attenuation plaque component compared to baseline findings

    Rhetorical question comprehension by Italian–German bilingual children

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    This study investigates for the first time the comprehension of rhetorical questions (RhQs) in bilingual children. RhQs are non-canonical questions, as they are not used to request information, but to express the speaker’s belief that the answer is already obvious. This special pragmatic meaning often arises by means of specific prosodic and lexical-syntactic cues. Being childhood learners, children have to acquire the concept of rhetoricity, but being bilinguals, they further need to acquire the different cues marking RhQs in their two languages. We tested 85 bilingual children (aged 6–9 years) with Italian as heritage language (HL) and German as majority language (ML) in both of their languages, using a forced-choice comprehension task. Our results show that RhQ comprehension improves with age in both languages. Bilingual children are able to exploit prosodic and syntactic cues to comprehend RhQs in their ML and HL with a slight advantage in the ML. This advantage could be either an effect of the cues used in the experiments in the two languages or of a higher proficiency in the ML. In addition, our results point to a later acquisition of prosodic rhetorical cues, which has implications for bilingual acquisition of non-canonicity in general

    Contributions from the DISC to the Aeolus Mission in 2022 and 2023

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    The Aeolus Data Innovation and Science Cluster (DISC) supports the Aeolus mission with a wide range of activities from instrument and product quality monitoring over retrieval algorithm improvements to numerical weather prediction (NWP) impact assessments for wind and aerosol forecasts. The Aeolus DISC provides support to ESA, Cal/Val teams, numerical weather prediction (NWP) centers, and scientific users for instrument special operations and calibration, for the re-processing of Aeolus products and through the provision of bi-annual updates of the L1A, L1B, L2A and L2B operational processors. The Aeolus DISC is coordinated by DLR with partners from ECMWF, KNMI, Météo-France, TROPOS, DoRIT, ABB, s&t, serco, OLA, Physics Solutions, IB Reissig and Les Myriades involving more than 40 scientists and engineers. The presentation will highlight the Aeolus DISC activities with a focus for the year 2022 and early 2023 since the last Aeolus workshop in Taormina, Italy during April 2022. This covers the evolution of the instrument performance including the significantly enhanced performance wrt. signal levels and random errors since the switch back to the flight model FM-A laser in October-November 2022. In addition, refinements of algorithms and processor updates will be outlined, which were introduced for the baseline B15 (13 September 2022) and B16 (expected to be released in spring 2023). A summary of the quality for the 3rd re-processing campaign for initial FM-A data (September 2018 - June 2019) will be give and an outlook to the 4th re-processing campaign covering the complete Aeolus mission. An outlook will also introduce some of the planned instrument activities in summer 2023 at the end of the expected mission lifetime of Aeolus. The Aeolus mission has fully achieved its mission objectives including the unprecedented demonstration of direct-detection Doppler wind lidar technology and high-power laser operation in space in the ultraviolet spectral region for more than 4 ½ years up to now - exceeding the planned mission lifetime of 3 years and 3 months. Aeolus wind products have clearly demonstrated positive impact on forecasts using several NWP models. Since early 2020, and thus only 1.5 years after launch, the Aeolus wind products were used in operation at ECMWF and at various NWP centers worldwide. This incredible success of Aeolus paved the way for the decision taken by the member states of ESA in November 2022 on the way forward of an operational follow-on wind lidar mission. These achievements of the Aeolus mission and its success were only possible with the essential and critical contributions from the Aeolus DISC. This demonstrates the need and potential for setting up such scientific consortia covering a wide range of expertise from instrument, processors, and scientific use of products for Earth Explorer type missions. The invaluable experience gained by the Aeolus DISC during the more than 4 years of Aeolus mission in orbit (preceded by a period of 20 years before launch by a similar study team) is a pre-requisite for the successful preparation of an operational follow-on wind lidar mission planned within the EUMETSAT Polar System (EPS) program

    Brownian molecules formed by delayed harmonic interactions

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    A time-delayed response of individual living organisms to information exchanged within flocks or swarms leads to the emergence of complex collective behaviors. A recent experimental setup by (Khadka et al 2018 Nat. Commun. 9 3864), employing synthetic microswimmers, allows to emulate and study such behavior in a controlled way, in the lab. Motivated by these experiments, we study a system of N Brownian particles interacting via a retarded harmonic interaction. For N 3 , we characterize its collective behavior analytically, by solving the pertinent stochastic delay-differential equations, and for N>3 by Brownian dynamics simulations. The particles form molecule-like non-equilibrium structures which become unstable with increasing number of particles, delay time, and interaction strength. We evaluate the entropy and information fluxes maintaining these structures and, to quantitatively characterize their stability, develop an approximate time-dependent transition-state theory to characterize transitions between different isomers of the molecules. For completeness, we include a comprehensive discussion of the analytical solution procedure for systems of linear stochastic delay differential equations in finite dimension, and new results for covariance and time-correlation matrice

    How Computers Entered the Classroom, 1960–2000: Historical Perspectives

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    In the history of education, the question of how computers were introduced into European classrooms has so far been largely neglected. This edited volume strives to address this gap. The contributions shed light on the computerization of education from a historical perspective, by attending closely to the different actors involved – such as politicians, computer manufacturers, teachers, and students –, political rationales and ideologies, as well as financial, political, or organizational structures and relations. The case studies highlight differences in political and economic power, as well as in ideological reasoning and the priorities set by different stakeholders in the process of introducing computers into education. However, the contributions also demonstrate that simple cold war narratives fail to capture the complex dynamics and entanglements in the history of computers as an educational technology and a subject taught in schools. The edited volume thus provides a comprehensive historical understanding of the role of education in an emerging digital society.+repphzhbib2023

    A geometric construction of U(n)U(\mathfrak{n}) for affine Kac-Moody algebras of type C~n\tilde{\mathsf{C}}_{n}

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    Inspired by the work of Geiss, Leclerc and Schr\"oer [Represent. Theory 20, (2016)] we realize the enveloping algebra of the positive part of an affine Kac-Moody Lie algebra of Dynkin type C~n\tilde{\mathsf{C}}_n as an convolution algebra of constructible functions on the varieties of locally free representations of the corresponding 1-Iwanaga-Gorenstein algebra H=HC(C,D,Ω)H=H_{\mathbb{C}}(C,D,\Omega) with minimal symmetrizer. To this end we exploit the fact that in this situation HH is gentle, and and the same time we use generalized reflection functors
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