21 research outputs found

    Finishing the euchromatic sequence of the human genome

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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∌99% of the euchromatic genome and is accurate to an error rate of ∌1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

    Entrepreneurial expectancy, task effort, and performance. Entrepreneurship:Theory and Practice

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    Research to date has not adequately explained the role that expectancy of entrepreneurial performance based on perceived ability plays in motivating persons to persevere on an entrepreneurial task. This study investigated the entrepreneurial expectancy, effort-performance linkage via a World Wide Web-based experiment involving 179 undergraduate business students at a large midwestern university. Results indicated that the type of feedback (positive versus negative) that individuals received regarding their entrepreneurial ability (regardless of actual ability) changed expectancies regarding future business start-up, but did not alter task effort or quality of performance. Individuals receiving positive feedback about their entrepreneurial abilities had higher entrepreneurial expectancies than individuals receiving negative feedback. We also found that males had higher expectancies regardless of experimental condition than females

    Exploring Gender-Related Perceptions of SME Success

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    Purpose – Small and medium enterprise (SME) research into the meaning and perception of success is now reaching beyond (the somewhat stereotypical) extrinsic success measures such as sales, number of employees, and profit. Researchers now identify the goals and expectations of the owner(s) of a business as central to their likely performance and preferred success metrics. Therefore, this paper aims to overlay perceptions of success and gender to establish whether success is conceptualised in the same way across genders. Design/methodology/approach – The study analyses the responses from 375 male and female SME owners to a range of quantitative success metrics and also explores the responses provided to a number of qualitative questions surrounding the owners’ perceptions of success. Findings – Although the average female-owned business in the study is significantly smaller than the average male-owned business, they perform equally well on extrinsic measures that relate outputs (profit) to inputs (assets and hours worked). Further, the female SME owners appear to be more satisfied with both the success of their business and their lifestyle, than their male counterparts. Originality/value – The findings suggest that the social feminists hold sway (men and women have different perceptions of success) and there is value in incorporating a feminine perspective when examining what business owners are looking for from their ventures. That is, measures of SME success need to adopt a person-centered perspective