23 research outputs found

    Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

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    Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 Â± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH

    Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

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    International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

    “All the Better to See You with, My Dear”: Facial Recognition and Privacy in Online Social Networks

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    An overview of the social and legal challenges attending facial-recognition technology use by online social networks explores ways to govern the associated privacy implications, specifically from a European data protection perspective.JRC.J.3-Information Societ

    My Image is My Property - Personal Image Protection on the Internet

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    The right to personal identity in the information age : a reappraisal of a lost right

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    Defence date: 24 February 2012Examining Board: Prof. Giovanni Sartor, EUI/Supervisor ; Prof. Miguel Poiares Maduro, EUI ; Prof. Yves Poullet, University of Namur ; Prof. Jon Bing, Norwegian Research Center for Computers and LawThis thesis presents a novel conceptualization of the right to personal identity: one that is adapted to the current technological environment in which we live, and that anticipates future technological developments. The study provides a comprehensive analysis of the right to personal identity, tracing its historical origins and main juridical developments from the Roman period to the present (and future) time. It also distinguishes the right to identity from other rights (such as the right to privacy and the right to data protection), thus contributing to the autonomy of this legal figure. This study puts forward a reconceptualization of the right to personal identity as a right that encompasses, controls and protects a series of different types of information related to or constitutive of our personal identity (digital, genetic, neural). Further to a right over information, the right to identity is presented as a right that regulates a series of identity movements and transformations between different ontological levels of “being” (possible real; actual virtual). Thus, the right to identity is the right to have one’s identity attributes registered (real possible), as well as the right to be recognized and identified (possible real) according to those defining features. The right to identity also encompasses the right to be represented as one wishes (virtual ?? actual) – that is, the right not to be misrepresented; the right to multiple identities (virtual actual) – that is, the right to create, control and uphold different identities in digital environments (such as pseudonyms and heteronyms); and the right to delete and recreate oneself (actual virtual), an identity movement that encompasses the right to be forgotten (and, consequently, the right to start again), as well as the eventual right to undergo genetic (post-human) and neural (memoryediting/ deletion) transformations. Following a postmodern conception of identity (as antiessentialistic, dynamic and multiple), the right to personal identity is defined as the right to be unique and different, not only from others but also from oneself. Further to this theoretical framework, the thesis also presents the foundations for an identity-regulatory system that grants the individual with the necessary and operational means to manage, control, change or delete his or her identity(ies)

    El olvido: el derecho a ser diferente de uno mismo. Una reconsideración del derecho a ser olvidado = Oblivion: The right to be different � from oneself reproposing the right to be forgotten

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    Este artículo propone una nueva conceptualización del derecho a ser olvidado, argumentando a favor de su construcción teórica y aplicación concreta amparadas en el derecho a la identidad. Desde esta perspectiva, el artículo pretende arrojar una nueva luz sobre el derecho a ser olvidado contribuyendo a una conceptualización y una aplicabilidad más desarrolladas al tiempo que aclara su ámbito de aplicación. Basándose en la distinción entre el derecho a la identidad y el derecho a la privacidad, el artículo presenta las ventajas de relacionar el derecho a ser olvidado con el derecho a la identidad. Con esa conceptualización basada en el derecho a la identidad, se afirma que el derecho a ser olvidado también debe aplicarse al contenido generado por los usuarios y la información tratada para fines personales eliminando la exención para actividades domésticas establecida en la directiva europea sobre protección de datos. El artículo también sostiene que el derecho al olvido, enmarcado como parte del derecho a la identidad personal, también debe abordar hechos públicos e información, ofreciendo una justificación racional y más fuerte con la que alcanzar un equilibrio mejor y más justo con el derecho a la libertad de información con el que compite. En el artículo se comentan los conflictos de derechos más relevantes que el derecho a ser olvidado tendrá que abordar, es decir, el conflicto con la libertad de expresión y el conflicto con la necesidad de preservar la memoria social. Como ramificación del derecho a la identidad, el derecho a ser olvidado se presenta como el derecho a ser diferente, no de los demás sino de uno mismo, es decir, de lo que uno era antes. El derecho a ser olvidado también subraya el proceso de creación de identidad no solo constructivo, sino también deconstructivo