1,775 research outputs found

    Organic Bioelectronics Development in Italy: A Review

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    In recent years, studies concerning Organic Bioelectronics have had a constant growth due to the interest in disciplines such as medicine, biology and food safety in connecting the digital world with the biological one. Specific interests can be found in organic neuromorphic devices and organic transistor sensors, which are rapidly growing due to their low cost, high sensitivity and biocompatibility. This trend is evident in the literature produced in Italy, which is full of breakthrough papers concerning organic transistors-based sensors and organic neuromorphic devices. Therefore, this review focuses on analyzing the Italian production in this field, its trend and possible future evolutions

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    Questo quarto volume del Centro “Ricerche di Gnoseologia e Metafisica”, sin dall’immagine di copertina, raffigurante la giovane Europa sul dorso del toro, manifesta il proprio tema portante, che dĂ  il titolo all’opera: Transizioni. La violenza del ratto, pur innegabile e inarrestabile, avviene lentamente e gradualmente: cosĂŹ siamo appunto noi nel divenire e, a fortiori, nel contingente, in una condizione di “transizione”, una condizione liminale dai bordi costantemente sfumati in cui la sfida Ăš affrontare questa “traduzione” (sia in senso fisico-etimologico, che metaforico) con tutto ciĂČ che essa implica e con tutti i suoi aspetti chiaroscurali (un po’ crepuscolari, un po’ aurorali). Una “transizione” di cui l’essere umano Ăš massimamente capace, nonchĂ© protagonista, in quanto assomma al mutare quella capacitĂ  astrattiva e quell’autocoscienza che gli consentono di domandarsi “chi sono io?” (un “chi” che si trasforma in un “dove” metafisico ed esistenziale nel tableau dell’essere) e, nello slittamento tra il non-piĂč-del-passato e il non-ancora-del-futuro, di gestire questa metamorfosi senza perdere se stesso e il mondo, trasformando il mutare in “performare”, ovvero muoversi tra e con le forme e mantenere il “filo narrativo” dell’esistenza. Plasmandosi e plasmando, “agendo-nel-farsi-della-realtà” e della storia (e non solo retrospettivamente), l’essere umano pone le condizioni di possibilitĂ  di una filosofia dell’azione e della liberazione propriamente detta. Questa Ăš la cornice tematica in cui si collocano i molteplici interventi del volume, cui hanno contribuito tanto i membri e le/i collaboratrici/tori del Centro RGM, quanto alcune/i studiose/i di fama internazionale che hanno partecipato alle attivitĂ  e iniziative di quest’ultimo.This fourth volume of the "Research of Gnoseology and Metaphysics" Centre, since the cover image, depicting young Europe on the back of the bull, manifests its main theme, which gives the work its title: Transitions. The violence of the rape, although undeniable and unstoppable, occurs slowly and gradually: this is precisely how we are in the process of becoming and, a fortiori, in the contingent, in a condition of "transition", a liminal condition in which the challenge is to face this "translation" (both in a physical-etymological and metaphorical sense) with all that it implies and with all its crepuscular and auroral aspects. A "transition" of which the human being is fully capable, as well as protagonist, as it adds to the change that abstractive capacity and self-awareness that allow him to ask himself "who am I?" (a “who” that transforms into a metaphysical and existential “where” in the tableau of being) and, in the slippage between the no longer-of-the-past and the not-yet-of-the-future, to manage this metamorphosis without losing himself and the world, transforming changing into "performing", that is, moving between and with forms and maintaining the "narrative thread" of existence. By shaping and molding, "acting-in-the-making-of-reality" and history (and not only retrospectively), the human being sets the conditions of possibility for a philosophy of action and liberation properly speaking. This is the thematic framework in which the multiple interventions of the volume are placed, to which the members and collaborators of the RGM Center contributed, as well as some internationally renowned scholars who participated in the activities and initiatives of the latter

    Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations

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    Tea Tree Oil (TTO) is an essential oil obtained from the distillation of Melaleuca alternifolia leaves and branches. Due to its beneficial properties, TTO is widely used as an active ingredient in antimicrobial preparations for topical use or in cosmetic products and contains about 100 different compounds, with terpinen-4-ol, Îł-terpinene and 1,8-cineole (or eucalyptol) being the molecules most responsible for its biological activities. In this work, the antimicrobial activity of whole TTO and these three major components was evaluated in vitro against fungi, bacteria and viruses. Molecular dynamics simulations were carried out on a bacterial membrane model and a Coxsackievirus B4 viral capsid, to propose an atomistic explanation of their mechanism of action. The obtained results indicate that the strong antimicrobial activity of TTO is attributable to the induction of an altered membrane functionality, mediated by the incorporation of its components within the lipid bilayer, and to a possible ability of the compounds to bind and alter the structural properties of the viral capsid

    Antenatal Diagnosis and Management of Fetal Intestinal Volvulus: Case Series and Literature Review

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    Fetal intestinal volvulus is a rare condition that can lead to hemorrhage, bowel necrosis, and urgent surgical treatment after birth. Thus, prompt diagnosis and treatment are essential to avoiding fetal or neonatal demise. Prenatal ultrasound is a keystone tool in the diagnostic course. However, sonographic findings tend to be non-specific, with limited understanding of the pathophysiology behind their atypical presentation. With a literature review and a case series, we aim to optimize the antenatal diagnosis and management of this rare but life-threatening condition. Six cases from our institution were retrospectively analyzed over 12 years. A literature review was conducted until December 2022. A total of 300 articles matched the keyword "Fetal volvulus", and 52 studies were eligible for the review. Our 6 cases are added to the 107 cases reported in the literature of fetal intestinal volvulus with antenatal ultrasound assessment and without associated gastroschisis or omphalocele. Several prenatal symptoms and ultrasound markers, even if not specific, were more frequently reported. Different experiences of management were described regarding follow-up, the timing of delivery, the mode of delivery, and surgery outcomes. This paper highlights the importance of suspecting and assessing fetal volvulus at routine ultrasound scans, describing the most frequent antenatal presentations and management in order to improve fetal and neonatal outcomes

    Calibration and performance assessment of the TOF-Wall detector of the FOOT experiment

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    In this contribution we discuss the calibration and performance of the TOF-Wall detector of the Fragmentation-Of-Target (FOOT) experiment. A thin carbon target was irradiated with carbon ions of several energies ranging from 150 to 400 MeV/u. The charge spectra of the produced fragments were used to calibrate the energy response. The energy resolution for a single bar was about 6%. The time resolution between the two layers ranged from 42 (150 MeV/u) to 62 ps (400 MeV/u)

    Primary membranous nephropathy in the Italian region of Emilia Romagna: results of a multicenter study with extended follow-up

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    Background: Since primary membranous nephropathy is a heterogeneous disease with variable outcomes and multiple possible therapeutic approaches, all 13 Nephrology Units of the Italian region Emilia Romagna decided to analyze their experience in the management of this challenging glomerular disease. Methods: We retrospectively studied 205 consecutive adult patients affected by biopsy-proven primary membranous nephropathy, recruited from January 2010 through December 2017. The primary outcome was patient and renal survival. The secondary outcome was the rate of complete remission and partial remission of proteinuria. Relapse incidence, treatment patterns and adverse events were also assessed. Results: Median (IQR) follow-up was 36 (24-60) months. Overall patient and renal survival were 87.4% after 5 years. At the end of follow-up, 83 patients (40%) had complete remission and 72 patients (35%) had partial remission. Among responders, less than a quarter (23%) relapsed. Most patients (83%) underwent immunosuppressive therapy within 6 months of biopsy. A cyclic regimen of corticosteroid and cytotoxic agents was the most commonly used treatment schedule (63%), followed by rituximab (28%). Multivariable analysis showed that the cyclic regimen significantly correlates with complete remission (odds ratio 0.26; 95% CI 0.08-0.79) when compared to rituximab (p < 0.05). Conclusions: In our large study, both short- and long-term outcomes were positive and consistent with those published in the literature. Our data suggest that the use of immunosuppressive therapy within the first 6 months after biopsy appears to be a winning strategy, and that the cyclic regimen also warrants a prominent role in primary membranous nephropathy treatment, since definitive proof of rituximab superiority is lacking

    Cardiovascular risk and the COVID-19 pandemic: a retrospective observational study in a population of healthcare professionals

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    Background and aim: To contain the spread of COVID-19, many countries imposed several restrictive measures, leading to radical changes in daily life behaviors. Healthcare workers experienced additional stress due to the increased risk of contagion, possibly causing an increase in unhealthy habits. We investigated changes in cardiovascular (CV) risk assessed by the SCORE-2 in a healthy population of healthcare workers during the COVID-19 pandemic; an analysis by subgroups was also conducted (sportspeople vs sedentary subjects). Methods and results: We compared medical examination and blood tests in a population of 264 workers aged over 40, performed yearly before (T0) and during the pandemic (T1, T2). We found a significant increase in the average CV risk, according to SCORE-2, during the follow-up in our healthy population, with a shift from a mean low-moderate risk profile at T0 (2.35%) to a mean high-risk profile at T2 (2.80%). Furthermore, in sedentary subjects was observed a greater and early increase in SCORE-2 compared to sportspeople. Conclusions: Since 2019, we observed an increase in CV risk profile in a healthy population of healthcare workers, particularly in sedentary subjects, highlighting the need to reassess SCORE-2 every year to promptly treat high-risk subjects, according to the latest Guidelines

    Nuclear physics midterm plan at Legnaro National Laboratories (LNL)

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    International audienceThe next years will see the completion of the radioactive ion beam facility SPES (Selective Production of Exotic Species) and the upgrade of the accelerators complex at Istituto Nazionale di Fisica Nucleare – Legnaro National Laboratories (LNL) opening up new possibilities in the fields of nuclear structure, nuclear dynamics, nuclear astrophysics, and applications. The nuclear physics community has organised a workshop to discuss the new physics opportunities that will be possible in the near future by employing state-of-the-art detection systems. A detailed discussion of the outcome from the workshop is presented in this report

    Elemental fragmentation cross sections for a O-16 beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT Delta E-TOF detectors

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    The study of nuclear fragmentation plays a central role in many important applications: from the study of Particle Therapy (PT) up to radiation protection for space (RPS) missions and the design of shielding for nuclear reactors. The FragmentatiOn Of Target (FOOT) collaboration aims to study the nuclear reactions that describe the interactions with matter of different light ions (like H-1, He-4, C-12, O-16) of interest for such applications, performing double differential fragmentation cross section measurements in the energy range of interest for PT and RPS. In this manuscript, we present the analysis of the data collected in the interactions of an oxygen ion beam of 400 MeV/u with a graphite target using a partial FOOT setup, at the GSI Helmholtz Center for Heavy Ion Research facility in Darmstadt. During the data taking the magnets, the silicon trackers and the calorimeter foreseen in the final FOOT setup were not yet available, and hence precise measurements of the fragments kinetic energy, momentum and mass were not possible. However, using the FOOT scintillator detectors for the time of flight (TOF) and energy loss (Delta E) measurements together with a drift chamber, used as beam monitor, it was possible to measure the elemental fragmentation cross sections. The reduced detector set-up and the limited available statistics allowed anyway to obtain relevant results, providing statistically significant measurements of cross sections eagerly needed for PT and RPS applications. Whenever possible the obtained results have been compared with existing measurements helping in discriminating between conflicting results in the literature and demonstrating at the same time the proper functioning of the FOOT Delta E-TOF system. Finally, the obtained fragmentation cross sections are compared to the Monte Carlo predictions obtained with the FLUKA software

    LambdAgrIoT: a new architecture for agricultural autonomous robots’ scheduling: from design to experiments

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    The usage of IoT and robots is more and more present in smart farming, and in particular in agro-ecology since robots are able to provide smart practices and avoid repetitive human tasks. However, these new technologies rise several research issues, which are strongly inter-related, about Farm Management Information System, such as robots’ programming, sensor data capture, management and processing at different layers of the IoT ecosystem. In particular, scheduling the tasks of different autonomous agricultural robots needs for a complex architecture that support at the same time real-time monitoring of robots and analysis of their historical data (Belhassena et al., Towards an architecture for agricultural autonomous robots’ scheduling. In: 2021 IEEE 25th international enterprise distributed object computing workshop (EDOCW), 2021. IEEE Computer Society, Los Alamitos, pp 194–203, 2021, https://doi.org/10.1109/EDOCW52865.2021.00049). Many studies investigated these issues, but to the best of our knowledge none has contributed with a fully-featured architecture design of monitoring and scheduling of autonomous agricultural robots. This work extends our previous work, where we propose a new architecture for autonomous agriculture robots scheduling, called LambdAgrIoT. LambdAgrIoT is designed to support big data and different types of workload (real-time, near real-time, analytic, and CRUD). We present the main features of each layer, and the implementation details. We also put to the test our LambdAgrIoT architecture using simulated data, and providing a real experience in a field. Results from real experiments show the feasibility of our new proposal. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature
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