6 research outputs found

    Apical and basal matrix remodeling control epithelial morphogenesis

    Get PDF
    Epithelial tissues can elongate in two dimensions by polarized cell intercalation, oriented cell division, or cell shape change, owing to local or global actomyosin contractile forces acting in the plane of the tissue. In addition, epithelia can undergo morphogenetic change in three dimensions. We show that elongation of the wings and legs of Drosophila involves a columnar-to-cuboidal cell shape change that reduces cell height and expands cell width. Remodeling of the apical extracellular matrix by the Stubble protease and basal matrix by MMP1/2 proteases induces wing and leg elongation. Matrix remodeling does not occur in the haltere, a limb that fails to elongate. Limb elongation is made anisotropic by planar polarized Myosin-II, which drives convergent extension along the proximal-distal axis. Subsequently, Myosin-II relocalizes to lateral membranes to accelerate columnar-to-cuboidal transition and isotropic tissue expansion. Thus, matrix remodeling induces dynamic changes in actomyosin contractility to drive epithelial morphogenesis in three dimensions

    The interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non-recovered patients

    Get PDF
    Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia

    The interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non-recovered patients

    Get PDF
    Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia

    Linking climate, sea level, and sedimentary response on the Texas shelf and upper slope: Examples from the Brazos and Colorado fluvial-deltaic systems

    No full text
    A 2D high-resolution seismic grid was combined with cores to develop a stratigraphic model of the East Texas shelf and slope, which showed that fluvial deltaic systems do not significantly impact upper slope stratigraphic sequences until very late during a eustatic fall. Rather, prograding delta lobes on the shelf correlate to a condensed section on the slope that continued until the deposition of a shelf-edge delta during OI Stage 3. Soon after, the Brazos system shifted away from the study area and a thick, shale-dominated healing phase wedge developed. These wedge sediments originated from a shelf-edge delta to the east and were transported westward along the upper slope revealing that significant sediment volumes moved not only downdip, but also laterally, into and out of the expected area of influence. During the transgression, the Brazos, Colorado, and Rio Grande fluvial systems each constructed a succession of deposits beginning with a fluvial-dominated delta (12--9 ka), followed by a wave-dominated delta (9--5 ka), and then retreated from the shelf. This unique succession correlates to climate changes occurring in their upper drainage basins. A separation in climate conditions between central Texas and northwestern Texas developed from 14--8 ka. Central Texas became arid, while northwest Texas experienced wet/dry fluctuations. Climate studies from other southwestern states indicate an intensification of the Arizona Monsoon was the cause, driven by a solar insolation maxima. Before this interval, climate and eustatic forcing functioned in tandem. Between 12--9 ka however, the two mechanisms diverged, with the insolation maximum occurring well before the sea level high. This divergence allowed the fluvial response to climate to be deconvolved from the response to eustacy. The Modern Brazos Delta continues to reflect a strong climate influence. The delta plain is composed of preserved ridge/trough pairs that correlate to climate fluctuations. Each rige/trough pair corresponds to a La Nina induced drought that is broken by an El Nino induced flood. Other strong El Nino events not represented on the delta plain belong to a dominantly wet period in Texas so that, without the proceeding drought, sediment was not available to initiate ridge development

    Espansione palatale rapida chirurgicamente assistita (SARPE) in pazienti adulti e tardo-adolescenti.

    No full text
    The authors describe the indications and the procedures of surgical assisted rapid palatal expansion with the showing of a clinical case. The technique described is a classical procedure: the ortodontic treatment follows surgery. The expansion gave the space to place a screw and a ceramic crown to close the space of an agenesia

    Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses

    No full text
    corecore