Bernhard Heisig and the Cultural Politics of East German Art

This dissertation focuses on the (East) German artist Bernhard Heisig (b. 1925), one of the most important German artists of the twentieth century. In English-language scholarship, however, he is virtually unknown, the result of lingering Cold War-era stereotypes that presume East Germany had no art, merely political propaganda or kitsch. This study focuses, in particular, on a crucial but little understood moment in Heisig's life and work, the decade between 1961 and 1971, a time when the style and subject matter for which he is best known today first emerged in his oeuvre. The introduction provides an overview of Heisig's reception in East, West, and unified Germany that will show how Cold War-era thinking affected--and continues to affect--his reception. The second chapter focuses on his past as a teenage soldier in the Second World War and the emergence of explicit references to this past in his art in the early 1960s. A comparison of his work to that by other artists suggests that there was more to its emergence at this point in time than simply personal reflection. It also reveals how his own experiences affected his portrayal of the subject. The third, fourth, and fifth chapters focus on a number of controversies that centered on Heisig and his work in the mid and late 1960s. It was during these years that the very definition of art in East Germany was under discussion: What is Socialist Realism? Heisig was a key figure in these debates, especially as they played out in Leipzig. A close investigation of the four main controversies in which he was involved reveals an artist deeply engaged with the society in which he lived and worked. Rather than a uniformly repressive system, the East German cultural scene was one of negotiation, sometimes heated, between artists and cultural functionaries. By engaging in these debates, Heisig helped to change what art was in East Germany and developed the commitment to figuration, tradition, and allegory for which he is praised today. In the end, this dissertation will offer a deeper understanding of both the artist and art under Socialism

Post-GWAS Polygenic Risk Score: Utility and Challenges.

Over the past decade, through genome-wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk. These genetic variants are common in the general population, but they exert small to modest effects on BMD, suggesting that the utility of any single variant is limited. However, a combination of effect sizes from multiple variants in the form of the polygenic risk score (PRS) can provide a useful indicator of fracture risk beyond that obtained by conventional clinical risk factors. In this perspective, we review the progress of genetics of osteoporosis and approaches for creating PRSs, their uses, and caveats. Recent studies support the idea that the PRS, when integrated into existing fracture prediction models, can help clinicians and patients alike to better assess the fracture risk for an individual, and raise the possibility of precision risk assessment. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research

A profiling analysis of contributions of cigarette smoking, dietary calcium intakes, and physical activity to fragility fracture in the elderly

Fragility fracture and bone mineral density (BMD) are influenced by common and modifiable lifestyle factors. In this study, we sought to define the contribution of lifestyle factors to fracture risk by using a profiling approach. The study involved 1683 women and 1010 men (50+ years old, followed up for up to 20 years). The incidence of new fractures was ascertained by X-ray reports. A “lifestyle risk score” (LRS) was derived as the weighted sum of effects of dietary calcium intake, physical activity index, and cigarette smoking. Each individual had a unique LRS, with higher scores being associated with a healthier lifestyle. Baseline values of lifestyle factors were assessed. In either men or women, individuals with a fracture had a significantly lower age-adjusted LRS than those without a fracture. In men, each unit lower in LRS was associated with a 66% increase in the risk of total fracture (non-adjusted hazard ratio [HR] 1.66; 95% CI, 1.26 to 2.20) and still significant after adjusting for age, weight or BMD. However, in women, the association was uncertain (HR 1.30; 95% CI, 1.11 to 1.53). These data suggest that unhealthy lifestyle habits are associated with an increased risk of fracture in men, but not in women, and that the association is mediated by BMD