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    Table S4. from Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog

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    Indigenous Peoples and confederated tribes past and present with ancestral ties to lands and waters from which R. boylii samples were collected. Indigenous Peoples and confederated tribes were compiled based on maps, information, and resources in “Tending the wild: Native American knowledge and the management of California's natural resources” by M. Kat Anderson (Univ of California Press, 2005) and on Native-Land.ca

    A portrait of the Higgs boson by the CMS experiment ten years after the discovery

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    In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spin–parity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from proton–proton collisions at a centre-of-mass energy of 13 teraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector

    Combining Spectral Amplitude and Phase Improves Terahertz Hyperspectral Imaging

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    We developed a method to analyze sample composition via hyperspectral imaging with terahertz time-domain spectroscopy (THz-TDS). Historically, THz spectral amplitude data alone have been most often used for hyperspectral analysis. We show advantages of simultaneously using both the amplitude and phase angle components of the THz transmission data in the analysis. Use of the complex transmission data improves the integrity of the sample component differentiation with respect to the sample composition. We incorporate principal component analysis and other simple machine learning algorithms into our data analysis methodology to automate the process of interpreting hyperspectral data and isolating unique components. As a demonstration, we automatically distinguish the structure of both a split-ring resonator and a sugar pellet sample

    <i>she</i> mutants display pericardial edema and loss of blood circulation.

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    (A) Zebrafish SHE protein diagram. she ci26 and ci30 mutant alleles are predicted to result in a frameshift and premature stop codons. SH2 domain and consensus tyrosine ABL phosphorylation sites are shown. (B-E) In situ hybridization analysis of she expression in wild-type embryos at 24, 48, 72 and 96 hpf stages. Note its expression in the dorsal aorta (arrows), intersegmental vessels, lateral line primordium (arrowhead, B) and neuromasts (arrowheads, C-E). (F-I) In situ hybridization analysis of she expression in she mutants at 24 hpf. Note that she expression is unaffected in sheci26 embryos while it is strongly reduced in sheci30 embryos. Homozygous sheci26 mutant embryos were obtained by an incross of sheci26-/-; fli1a:she-2A-mCherry; kdrl:GFP parents (which are viable due to fli1a:she-2A-mCherry rescue) and selected for mCherry negative embryos. Wild-type control embryos were obtained by incross of sibling wt; fli1a:she-2A-mCherry parents and selected for mCherry-negative embryos. sheci30 embryos were obtained by incross of sheci30+/- parents and genotyped after in situ hybridization. 25% (10 out of 40) embryos showed strong reduction in she expression which correlated with the mutant phenotype. (J-M) Brightfield images of sheci26 and sheci30 mutant embryos and their siblings (wild-type and or heterozygous) at 4 dpf. Note the pericardial edema (arrowheads) in the mutant embryos. Embryos were obtained by the incross of heterozygous parents in kdrl:GFP background. 24.9% (265 out of 1064) and 24.2% (80 out of 330) embryos obtained in sheci26 or sheci30 incross, respectively, showed this phenotype. A subset of embryos was genotyped to confirm the correlation between the phenotype and genotype.</p

    Evidence of pair production of longitudinally polarised vector bosons and study of CP properties in ZZ → 4ℓ events with the ATLAS detector at s = 13 TeV