Pullback attractors for a singularly nonautonomous plate equation

We consider the family of singularly nonautonomous plate equation with structural damping $$u_{tt} + a(t,x)u_{t} + (- \Delta) u_{t} + (-\Delta)^{2} u + \lambda u = f(u),$$ in a bounded domain $\Omega \subset \R^n$, with Navier boundary conditions. When the nonlinearity $f$ is dissipative we show that this problem is globally well posed in $H^2_0(\Omega) \times L^2(\Omega)$ and has a family of pullback attractors which is upper-semicontinuous under small perturbations of the damping $a$

Ampliando a participação dos genes responsivos a T3 e cAMP na regulação da termogênese gerada pelas vias de oxidação biológica

OBJECTIVE: We sought to identify glycolysis, glycogenolysis, lipolysis, Krebs cycle, respiratory chain, and oxidative phosphorylation enzymes simultaneously regulated by T3 and cAMP. MATERIALS AND METHODS: We performed in silico analysis of 56 promoters to search for cis-cAMP (CREB) and cis-thyroid (TRE) response elements, considering UCP1, SERCA2 and glyceraldehyde 3-phosphate dehydrogenase as reference. Only regulatory regions with prior in vitro validation were selected. RESULTS: 29/56 enzymes presented potential TREs in their regulatory sequence, and some scored over 0.80 (better predictive value 1): citrate synthase, phosphoglucose isomerase, succinate dehydrogenases A/C, UCP3, UCP2, UCP4, UCP5, phosphoglycerate mutase, glyceraldehyde 3-P dehydrogenase, glucokinase, malate dehydrogenase, acyl-CoA transferase (thiolase), cytochrome a3, and lactate dehydrogenase. Moreover, some enzymes have not yet been described in the literature as genomically regulated by T3. CONCLUSION: Our results point to other enzymes which may possibly be regulated by T3 and CREB, and speculate their joint roles in contributing to the optimal thermogenic acclimation.OBJETIVO: Identificar enzimas das vias da glicólise, glicogenólise, lipólise, ciclo de Krebs, cadeia respiratória e fosforilação oxidativa possivelmente reguladas por T3 e cAMP. MATERIAIS E MÉTODOS: Analisamos 56 genes metabólicos in silico mediante a identificação dos elementos cis de regulação gênica responsivos ao T3 e cAMP (TREs, thyroid response elements e CREs, cAMP response elements), utilizando como referência o promotor da UCP1, SERCA2 e gliceraldeído 3-fosfato desidrogenase. Selecionamos somente os promotores com estudo funcional prévio in vitro. RESULTADOS: 29/56 enzimas apresentaram TREs em suas regiões regulatórias, parte com escore > 0,80 (melhor valor preditivo 1): citrato sintase, fosfoglucose isomerase, succinato desidrogenase A/C, UCP3, UCP2, UCP4, UCP5, fosfoglicerato mutase, gliceraldeído 3-P desidrogenase, glucoquinase, malato desidrogenase, acil-CoA transferase (tiolase), citocromo a3, e lactato desidrogenase; parte desconhecida como regulada por T3. CONCLUSÃO: Os resultados do presente estudo apontam para novos genes regulados por T3 e cAMP e, por conseguinte, sua contribuição na regulação da termogênese.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Impacts of the “Plastic Bag Law” in the Grocery Retail in the city of São Paulo/Brazil

Among the waste generated by retail, the plastic bag, which has its main use for the transportation of products, is a constant component of household waste and negatively impacts the environment. In this context, Municipal Law 15,374 prohibited the free distribution of plastic bags in the city of São Paulo / Brazil, as of April 2015, and brought as an alternative the use of returnable bags and biodegradable bags in an attempt to reduce environmental impact caused by improper disposal of the plastic. Therefore, the purpose of this research was to analyze the impact of said Law on the reduction of the purchase of plastic bags made by the grocery retail in the city of São Paulo. A survey was conducted with data from two grocery retail stores in the city of São Paulo, between January and December 2015. The results showed that the implementation of the law reduced the volume of plastic bags provided by supermarkets without compromising the flow of people and financial income

O ensino por investigação e a possibilidade de elaborar hipóteses: a fermentação e seu caráter investigativo

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014Este trabalho teve como objetivo aplicar a Situação de Estudo introduzindo na aula experimental o ensino por investigação e analisar a familiaridade com que os alunos desenvolveriam hipóteses a respeito de determinado problema. Observamos no desenvolvimento do trabalho que os alunos mostram-se bastante motivados com a ideia de elaborar explicações para o experimento tratado no laboratório, correlacionaram o conteúdo estudado nas aulas teóricas com a prática experimental e demonstraram interesse maior a respeito do conteúdo teórico. Além disso, constatamos que o ensino por investigação pôde ser implementada com uma mudança feita a partir de uma atividade já realizada pela professor

Enhancing T3 and cAMP responsive gene participation in the thermogenic regulation of fuel oxidation pathways Ampliando a participação dos genes responsivos a T3 e cAMP na regulação da termogênese gerada pelas vias de oxidação biológica

ABSTRACT Objective: We sought to identify glycolysis, glycogenolysis, lipolysis, Krebs cycle, respiratory chain, and oxidative phosphorylation enzymes simultaneously regulated by T3 and cAMP. Materials and methods: We performed in silico analysis of 56 promoters to search for cis-cAMP (CREB) and cis-thyroid (TRE) response elements, considering UCP1, SERCA2 and glyceraldehyde 3-phosphate dehydrogenase as reference. Only regulatory regions with prior in vitro validation were selected. Results: 29/56 enzymes presented potential TREs in their regulatory sequence, and some scored over 0.80 (better predictive value 1): citrate synthase, phosphoglucose isomerase, succinate dehydrogenases A/C, UCP3, UCP2, UCP4, UCP5, phosphoglycerate mutase, glyceraldehyde 3-P dehydrogenase, glucokinase, malate dehydrogenase, acyl-CoA transferase (thiolase), cytochrome a3, and lactate dehydrogenase. Moreover, some enzymes have not yet been described in the literature as genomically regulated by T3. Conclusion: Our results point to other enzymes which may possibly be regulated by T3 and CREB, and speculate their joint roles in contributing to the optimal thermogenic acclimation. Arq Bras Endocrinol Metab. 2010;54(4):381-9 Keywords Thermogenesis; T3R; CREB; genomic regulation; fuel oxidation ReSumo Objetivo: Identificar enzimas das vias da glicólise, glicogenólise, lipólise, ciclo de Krebs, cadeia respiratória e fosforilação oxidativa possivelmente reguladas por T3 e cAMP. Materiais e méto-dos: Analisamos 56 genes metabólicos in silico mediante a identificação dos elementos cis de regulação gênica responsivos ao T3 e cAMP (TREs, thyroid response elements e CREs, cAMP response elements), utilizando como referência o promotor da UCP1, SERCA2 e gliceraldeído 3-fosfato desidrogenase. Selecionamos somente os promotores com estudo funcional prévio in vitro. Resultados: 29/56 enzimas apresentaram TREs em suas regiões regulatórias, parte com escore ≥ 0,80 (melhor valor preditivo 1): citrato sintase, fosfoglucose isomerase, succinato desidrogenase A/C, UCP3, UCP2, UCP4, UCP5, fosfoglicerato mutase, gliceraldeído 3-P desidrogenase, glucoquinase, malato desidrogenase, acil-CoA transferase (tiolase), citocromo a3, e lactato desidrogenase; parte desconhecida como regulada por T3. Conclusão: Os resultados do presente estudo apontam para novos genes regulados por T3 e cAMP e, por conseguinte, sua contribuição na regulação da termogênese. Arq Bras Endocrinol Metab. 2010;54(4):381-

Distribuição de Heteroptera Aquáticos (Insecta) em Diferentes Tipos de Substratos de Córregos do Cerrado Matogrossense

A comunidade de Heteroptera de córregos do cerrado do Leste Matogrossense foi analisada para determinar os tipos de substratos que contemplam a maior variação de composição de espécies. Foram realizadas coletas nos substratos de folhiço de corredeira e remanso, raiz, cascalho, pedra (matacão), areia e na superfície d’água (camada de tensão superficial) das nascentes, trechos médios e foz dos córregos Santo Antônio e Colher em dezembro/2004 e julho/2005, com cada substrato representado por seis subamostras. Foram coletados 333 indivíduos distribuídos em 11 famílias, 20 gêneros e 30 morfoespécies (17 Nepomorpha e 13 Gerromorpha), sendo os Gerromorpha mais abundantes (172 indivíduos). A riqueza estimada de Gerromorpha nos substratos foi superior em coletas na superfície d’água, enquanto Nepomorpha apresentou maior riqueza em raiz, seguido por cascalho e folhiço de corredeira. Os substratos inorgânicos (pedra e areia) apresentaram reduzida riqueza de Heteroptera. Entre os Gerromorpha, Limnogonus aduncus aduncus Drake & Harris, Rhagovelia elegans Uhler, Neogerris lubricus White e Brachymetra sp.1 foram associados com coletas de superfície e Stridulivelia anta Polhemus & Spangler com substrato raiz. Em Nepomorpha, Martarega chinai Hynes foi associado com coletas de superfície, enquanto que Ambrysus sp. 1 mostrou associação ao folhiço de corredeira, de remanso, raiz e superfície. Com esses resultados ressaltamos que trabalhos que visem levantamentos rápidos da comunidade de Heteroptera devem priorizar coletas de superfície para Gerromorpha e de raiz para Nepomorpha, pois esses substratos abrigam as maiores riquezas de cada infraordem, contemplando 83% e 64% da riqueza de espécie desses grupos respectivamente. Distribution of Aquatic Heteroptera (Insecta) From Different Types of Streams Substrate of Cerrado in Mato Grosso Abstract. The Heteroptera community of Cerrado streams in east of Mato Grosso was analyzed to determine the types of substrate that contemplate the largest variation in species composition. Samples were performed in the leaf litter substrates from rapids and backwaters, root, gravel, stone (boulder), sand and on the water surface (surface tension layer) of springs, mean stretches and mouths of the Santo Antônio and Colher streams on December/2004 and July/2005, with six subsamples each substrate. Were collected 333 specimens distributed in 11 families, 20 genus and 30 morphospecies (17 Nepomorpha and 13 Gerromorpha), being Gerromorpha the most abundant (172 specimens). The estimated richness of Gerromorpha in the substrates was higher in samples from water surface, while Nepomorpha showed higher richness in root, followed by gravel and leaf litter from rapids. The inorganic substrates (stone and sand) showed lower richness of Heteroptera. Among Gerromorpha, Limnogonus aduncus aduncus Drake & Harris, Rhagovelia elegans Uhler, Neogerris lubricus White and Brachymetra sp.1 were associated to surface samples and Stridulivelia anta Polhemus & Spangler to root substrate. In Nepomorpha, Martarega chinai Hynes was associated to surface samples, while Ambrysus sp. 1 showed association to leaf litter from rapids, backwaters, root and surface. The results suggest that studies which aim for rapid surveys of Heteroptera community should prioritize surface samples for Gerromorpha and root samples for Nepomorpha, because these substrates shelter the greatest richness of each infra-order, contemplating 83% and 64% of species richness in these groups respectively

Oncologic patients representations about the antineoplastic chemotherapy treatment

Objective: To understand and identify the representations of cancer patients on antineoplastic chemotherapy treatment and nursing care. Methods: Descriptive, qualitative research, analyzed regarding the phenomena of the Theory of Social Representations and content analysis technique proposed by Bardin, held from June 24 to July 31, 2015, with 22 patients diagnosed with cancer and under chemotherapy treatment. Results: After analysis of the collected material were consolidated four thematic units, named: "Chemotherapy: the chance of cure", "Nursing care in chemotherapy", "The daily life of interpersonal relationships during chemotherapy treatment" and "The difficulties during the chemotherapy". Conclusion: Through research, you can see the importance of health education for the understanding of patients and their families about cancer and its treatment