Caught in the Seamless Web: Does the Internet's Global Reach Justify Less Freedom of Speech?

A federal appellate court will decide this year whether French anti-discrimination law can restrict freedom of speech on U.S.-based websites that are accessible in France. A Paris court ruled in 2000 that the Yahoo! website violated French law because its users offered for sale certain Nazi artifacts. However, to force compliance with the order, French plaintiffs must seek enforcement from a U.S. court. In response, Yahoo! sought a declaratory ruling and a federal district court held that enforcing the French order would violate the First Amendment. The matter is now on appeal. The Yahoo! case presents the question of whether the Internet should be governed by myriad local censorship laws from around the world. U.S. courts have held uniformly that the Internet should receive the highest degree of First Amendment protection. They have been influenced profoundly by the medium's global reach and have invalidated most restrictions so as not to interrupt the "never-ending worldwide conversation" that the Internet makes possible. A contrary result in the Yahoo! case would embrace a very different philosophy -- that Internet speakers must "show their papers" at each nation's borders to ensure that their speech is acceptable to local authorities. Other nations may treat their citizens as fragile children if they wish, or worse, as enemies of the state. But U.S. courts should not permit the seeds of foreign censorship to be planted on U.S. soil by finding that such restrictions are enforceable here

MicroRNA detection on microsensor arrays by SPR imaging measurements with enzymatic signal enhancement.

We investigated sequence-specific and simultaneous microRNA (miRNA) detections by surface plasmon resonance (SPR) imaging measurements on SPR chips possessing an Au spot array modified with probe DNAs based on a miRNA-detection-selective SPR signal amplification method. MiRNAs were detected with the detection limit of the attomole level by SPR imaging measurements for different miRNA concentrations on a single chip. SPR signals were enhanced based on a combination process of sequence-specific hybridization of the miRNA to the probe DNAs, extension reaction of polyadenine (poly(A)) tails by poly(A) polymerase, binding of a ternary complex of T30-biotin/horseradish peroxidase (HRP)-biotin/streptavidin to the poly(A) tails, and the oxidation reaction of tetramethylbenzidine (TMB) on the HRP by providing a blue precipitate on the surface. This process sequence-specifically and dramatically amplified the SPR signals. This is a simple, cost-effective, and feasible signal amplification method based on the organic compound TMB instead of metal nanoparticles

The determination of measures of software reliability

Measurement of software reliability was carried out during the development of data base software for a multi-sensor tracking system. The failure ratio and failure rate were found to be consistent measures. Trend lines could be established from these measurements that provide good visualization of the progress on the job as a whole as well as on individual modules. Over one-half of the observed failures were due to factors associated with the individual run submission rather than with the code proper. Possible application of these findings for line management, project managers, functional management, and regulatory agencies is discussed. Steps for simplifying the measurement process and for use of these data in predicting operational software reliability are outlined

Cardiovascular Disease: Analyzing Primary and Secondary Prevention Strategies

Cardiovascular disease (CVD) is the single most common cause of death around the world, with an increasing number of people living with coronary heart disease (CHD) (Anderson et al., 2016). Smoking and tobacco use are major risk factors for CVD and are the leading preventable causes of death globally. The chance of developing CVD is reversible and the elimination of tobacco use after a heart attack can reduce an individual\u27s risk of CVD mortality by 36% over two years (Rigotti & Clari, 2013). Smoking cessation is the central element of primary and secondary prevention strategies. Primary interventions can include aspirin and statin therapy, while secondary preventions include, but are not limited to, exercise-based rehabilitation and psychosocial interventions. The purpose of this project is to determine whether primary or secondary interventions are more effective in reducing the risk of developing CVD. To answer the clinical question, a thorough review of the literature was organized in the databases, Cochrane Library, National Guideline Clearinghouse, CINAHL, and PubMed Clinical Queries. The search yielded relevant sources of evidence which met the inclusion and exclusion criteria. Evidence included systematic reviews and randomized control trials. The findings regarding the best interventions to reduce the risk of cardiovascular disease will be presented. These findings will assist healthcare providers in implementing the best quality of care to their patients