55,001 research outputs found

    Performance of the local reconstruction algorithms for the CMS hadron calorimeter with Run 2 data

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    A description is presented of the algorithms used to reconstruct energy deposited in the CMS hadron calorimeter during Run 2 (2015–2018) of the LHC. During Run 2, the characteristic bunch-crossing spacing for proton-proton collisions was 25 ns, which resulted in overlapping signals from adjacent crossings. The energy corresponding to a particular bunch crossing of interest is estimated using the known pulse shapes of energy depositions in the calorimeter, which are measured as functions of both energy and time. A variety of algorithms were developed to mitigate the effects of adjacent bunch crossings on local energy reconstruction in the hadron calorimeter in Run 2, and their performance is compared

    Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents

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    The need for anticancer therapies that overcome metallodrug resistance while minimizing adverse toxicities is targeted, herein, using titanium coordination complexes. Octahedral titanium­(IV) trans,mer-[Ti­{R1N­(CH2–2-MeO-4-R1-C6H2)2}2] [R1 = Et, allyl, n-Pr, CHO, F, CH2(morpholino), the latter from the formyl derivative; R2 = Me, Et; not all combinations] are attained from Mannich reactions of commercial 2-methoxyphenols (27–74% overall yield, 2 steps). These crystalline (four X-ray structures) Ti­(IV)-complexes are active against MCF-7, HCT-116, HT-29, PANC-1, and MDA-MB-468 cancer cell lines (GI50 = 0.5–38 μM). Their activity and cancer selectivity (vs nontumor MRC-5 cells) typically exceeds that of cisplatin (up to 16-fold). Proteomic analysis (in MCF-7) supported by other studies (G2/M cell cycle arrest, ROS generation, γH2AX production, caspase activation, annexin positivity, western blot, and kinase screens in MCF-7 and HCT-116) suggest apoptosis elicited by more than one mechanism of action. Comparison of these data to the modes of action proposed for salan Ti­(IV) complexes is made

    A Single-Session Virtual Validation Intervention for Family Members of Youth Experiencing Emotion Dysregulation: A Mixed-Methods Pilot Study

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    Family member validation has been found to reduce emotion dysregulation among youth. To date, however, no interventions exist to teach family members of youth experiencing emotion dysregulation the skill of validation exclusively. The purpose of this mixed methods pilot study was to test a single-session virtual intervention on the topic of validation for family members currently on a waitlist for the ‘Family Connections’ program. Results support the feasibility, acceptability and utility of the intervention including the single-session and virtual formats. The components of the intervention perceived as most useful to family members were practice exercises, the virtual chat function, and self-validation content. Applied knowledge of validation and perceived hope increased significantly following participation. This study offers preliminary evidence that validation may be a skill that can be learned in a single-session virtual intervention by family members of youth experiencing emotion dysregulation, and suggests implications for clinical practice, research, and theory.</p

    Extracting the speed of sound in the strongly interacting matter created in ultrarelativistic lead-lead collisions at the LHC