218 research outputs found

    Integrated or segmented? a wavelet transform analysis on relationship between stock and real estate markets

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    The goal of this paper is to investigate the relationship between stock and real estate markets via wavelet analysis. Based on wavelet transform, stock price index and REITs index are firstly decomposed into “volatility componentsâ€, that is, the wavelet coefficients. Secondly, we test the causality relationship between stock price index and REITs index of each subband under the concept of multi-resolution representation. The result revealed that the relationship between stock and real estates markets is neither simply segmented nor purely integrated; the behaviors would vary not only over various observation time scales but also with different REITs.REITS markets, stock markets, causality, wavelet transform

    The FZ Strategy to Compress the Bitmap Index for Data Warehouses

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    Data warehouses contain data consolidated from several operational databases and provide the historical, and summarized data which is more appropriate for analysis than detail, individual records. Fast response time is essential for on-line decision support. A bitmap index could reach this goal in read-mostly environments. For the data with high cardinality in data warehouses, a bitmap index consists of a lot of bitmap vectors, and the size of the bitmap index could be much larger than the capacity of the disk. The WAH strategy has been presented to solve the storage overhead. However, when the bit density and clustering factor of 1\u27s increase, the bit strings of the WAH strategy become less compressible. Therefore, in this paper, we propose the FZ strategy which compresses each bitmap vector to reduce the size of the storage space and provide efficient bitwise operations without decompressing these bitmap vectors. From our performance simulation, the FZ strategy could reduce the storage space more than the WAH strategy

    The potential application of ultra-nanocrystalline diamond films for heavy ion irradiation detection

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    [[abstract]]The potential of utilizing the ultra-nanocrystalline (UNCD) films for detecting the Au-ion irradiation was investigated. When the fluence for Au-ion irradiation is lower than the critical value (fc = 5.0 × 1012 ions/cm2) the turn-on field for electron field emission (EFE) process of the UNCD films decreased systematically with the increase in fluence that is correlated with the increase in sp2-bonded phase (π*-band in EELS) due to the Au-ion irradiation. The EFE properties changed irregularly, when the fluence for Au-ion irradiation exceeds this critical value. The transmission electron microscopic microstructural examinations, in conjunction with EELS spectroscopic studies, reveal that the structural change preferentially occurred in the diamond-to-Si interface for the samples experienced over critical fluence of Au-ion irradiation, viz. the crystalline SiC phase was induced in the interfacial region and the thickness of the interface decreased. These observations implied that the UNCD films could be used as irradiation detectors when the fluence for Au-ion irradiation does not exceed such a critical value.[[incitationindex]]SCI[[booktype]]電子

    QUANTITATIVE ANALYSIS OF THE DYNAMIC BALANCE ABILITY BETWEEN THE COLLEGE STUDENTS AND HANDBALL PLAYERS

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    The purpose of this study was to investigate the differences of dynamic standing ability (Balance keeping time; BKT) and the change of the angular velocity (deg. / s) of a platform between healthy non-athelete female students and handball players using an unstable platform-like seesaw. Methods: The seesaw is capable of rotating side to side in both directions of right and left; it was set horizontally at an angle of zero degrees as a base, with the maximum degree of the seesaw inclination set at 25 degrees. In addition, a high-speed digital video camera (SONY-HDR-CX520V) was set to record the BKT and the changes of motion in the frontal plane from both sides of the plate. Results: There is a significant difference observed in both BKT and the change of angular velocity between non-athletes and handball players. Conclusion: The findings suggest the data gained from the experiments may establish a dynamic balance fitness norm and can be used as an assessment method of the lower extremity coordination ability

    Human parvovirus B19 nonstructural protein NS1 enhanced the expression of cleavage of 70 kDa U1-snRNP autoantigen

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    <p>Abstract</p> <p>Background</p> <p>Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitochondrial-dependent apoptosis in COS-7 cells, the precise mechanism of B19-NS1 in developing autoimmunity is still obscure.</p> <p>Methods</p> <p>To further examine the effect of B19-NS1 in presence of autoantigens, COS-7 cells were transfected with pEGFP, pEGFP-B19-NS1 and pEGFP-NS1K334E, a mutant form of B19-NS1, and detected the expressions of autoantigens by various autoantibodies against Sm, U1 small nuclear ribonucleoprotein (U1-snRNP), SSA/Ro, SSB/La, Scl-70, Jo-1, Ku, and centromere protein (CENP) A/B by using Immunoblotting.</p> <p>Results</p> <p>Significantly increased apoptosis was detected in COS-7 cells transfected with pEGFP-B19-NS1 compared to those transfected with pEGFP. Meanwhile, the apoptotic 70 kDa U1-snRNP protein in COS-7 cells transfected with pEGFP-B19-NS1 is cleaved by caspase-3 and converted into a specific 40 kDa product, which were recognized by anti-U1-snRNP autoantibody. In contrast, significantly decreased apoptosis and cleaved 40 kDa product were observed in COS-7 cells transfected with pEGFP-NS1K334E compared to those transfected with pEGFP-B19-NS1.</p> <p>Conclusions</p> <p>These findings suggested crucial association of B19-NS1 in development of autoimmunity by inducing apoptosis and specific cleavage of 70 kDa U1-snRNP.</p

    A novel sol-gel Bi2-xHfxO3+x/2 radiopacifier for mineral trioxide aggregates (MTA) as dental filling materials

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    Funding Information: The authors would like to thank Taipei Medical University Hospital for financially sup-porting this work under grant no. 110TMU-TMUH-16 and partially supported by MOST 109-2221-E-038-014. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Mineral trioxide aggregate (MTA) is well known as an effective root canal filling material for endodontics therapy. Within MTA, bismuth oxide (Bi2O3) serving as the radiopacifier still has biocompatibility concerns due to its mild cytotoxicity. In the present study, we tried to modify the Bi2O3 radiopacifier by doping hafnium ions via the sol-gel process and investigated the effects of different doping ratios (Bi2-xHfxO3+x/2, x = 0–0.3) and calcination temperatures (400–800 °C). We mixed various precursor mixtures of bismuth nitrate (Bi(NO3)3·5H2O) and hafnium sulfate (Hf(SO4)2) and controlled the calcination temperatures. The as-prepared Hf-doped Bi2O3 radiopaci-fier powders were investigated by thermogravimetric analysis (TGA), X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Portland cement/radiopacifier/calcium sulfate (75/20/5) were mixed and set by deionized water (powder to water ratio = 3:1). Changes in radiopacity, diametral tensile strength (DTS), and in vitro cell viability of the hydrated MTA-like cement were carried out. The experimental results showed that the group containing radiopacifier from sol-gelled Bi/Hf (90/10) exhibited significantly higher radiopacity (6.36 ± 0.34 mmAl), DTS (2.54 ± 0.29 MPa), and cell viability (84.0±8.1%) (p < 0.05) when compared to that of Bi/Hf (100/0) powders. It is suggested that the formation of β-Bi7.78Hf0.22O12.11 phase with hafnium addition and calcining at 700 °C can prepare novel bismuth/haf-nium composite powder that can be used as an alternative radiopacifier for root canal filling mate-rials.publishersversionPeer reviewe

    Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling

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    Increased cell death of cardiomyocyte by oxidative stress is known to cause dysfunction of the heart. O. gratissimum is one of the more well-known medicinal plants among the Ocimum species and widely used in treatment of inflammatory diseases. In this study, we hypothesized that aqueous extract of O. gratissimum leaf (OGE) may protect myocardiac cell H9c2 from oxidative injury by hydrogen peroxide (H2O2). Our results revealed that OGE pretreatment dose-dependently protects H9c2 cells from cell death when exposed to H2O2. Additionally, DNA condensation induced by H2O2 was also reduced by OGE pretreatment, suggesting that Ocimum gratissimum extract may attenuate H2O2-induced chromosome damage. Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8. Additionally, OGE pretreatment significantly upregulated Bcl-2 expression and Akt phosphorylation, and slightly affected the phosphorylation of mitogen-activated protein kinases including p38 MAPK and JNK. Taken together, our findings revealed that Ocimum gratissimum extract effectively inhibited the mitochondrial pathway and upregulated Bcl-2 expression, which may be important in protecting H9c2 cells from H2O2-induced cell death

    Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA

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    This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation. A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat. This nerve gap was then filled with different concentrations of danshen (0–100 mg/mL). The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner. RSC96, Schwann cells were also administered with danshen (0, 20, 40, 60, 80, and 100 μg/mL) and tanshinone IIA (0, 2, 4, 6, 8, and 10 μg/mL). In lower concentrations, danshen and tanshinone IIA exhibited an apparent effect on Schwann cells. Similar effects were also demonstrated in the FGF-2-uPA regulating cascade and cell cycle proliferative protein results. Schwann cell migration was elevated as well. We used MAPK-signaling chemical inhibitors and identified the proliferative effects of danshen and tanshinone IIA as MAPK-signaling dependent. The results from the in vitro systems indicate that danshen and tanshinone IIA can be used to induce Schwann cell proliferation, and in vivo results potentially suggest that danshen and tanshinone IIA might enhance neuron regeneration

    Estimation of cell concentration using high-frequency ultrasonic backscattering

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    Abstract Cell concentration is a crucial quantity for both clinical diagnostic examinations and cell culture studies. However, typical modalities for cell concentration measurements are either time-consuming or not cost-effective. In the present study, cell concentration is estimated using high-frequency ultrasonic backscattering. Validation tests indicate that the proposed method can differentiate red blood cells (RBCs) of various hematocrits. A 50-MHz ultrasound system with appropriate sensitivity is utilized to estimate cell concentrations from a small volume of RBCs suspended in saline, with hematocrits ranging from 1.66 × 10 -4 to 10%, and fibroblasts, with concentrations ranging from 2 × 10 4 to 128 × 10 4 cells/mL. The backscatter strength and statistical distribution, characterized by the Nakagami parameter, are calculated from gated signals for quantitatively assessing the samples. Results show that the backscatter strength of RBCs linearly increases with increasing hematocrit level in the hematocrit range of 3 to 10%, which agrees well with results of previous studies. The backscatter strength of RBCS has an exponential relationship with the hematocrit level in the hematocrit range of 1.66 × 10 -4 to 3%. The corresponding Nakagami parameter is sensitive to electronic noise as long as the signal-to-noise ratio decreasing follows with the decrease of RBC hematocrits at the concentration lower than 0.85%. The backscatter strength of fibroblasts exponentially increases with increasing fibroblasts concentration, which is consistent with results obtained from typical optical density measurements. A linear relationship, with correlation coefficient of 0.99, between the results of ultrasonic backscattering and those of the optical density measurements is established. High-frequency ultrasonic backscattering can be applied to sensitively estimate the concentrations of small volumes of cells

    Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats

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    Garlic oil has been reported to protect the cardiovascular system; however, the effects and mechanisms behind the cardioprotection of garlic oil on diabetes-induced cardiaomyopathy are unclear. In this study, we used streptozotocin (STZ)-induced diabetic rats to investigate whether garlic oil could protect the heart from diabetes-induced cardiomyopathy. Wistar STZ-induced diabetic rats received garlic oil (0, 10, 50 or 100 mg kg_1 body weight) by gastric gavage every 2 days for 16 days. Normal rats without diabetes were used as control. Cardiac contractile dysfunction and cardiac pathologic hypertrophy responses were observed in diabetic rat hearts. Cardiac function was examined using echocardiography. In addition to cardiac hypertrophy-related mitogen-activated protein kinases (MAPK) pathways (e.g., p38, c-Jun N-terminal kinases (JNK) and extracellularly responsive kinase (ERK1/2)), the IL-6/MEK5/ERK5 signaling pathway was greatly activated in the diabetic rat hearts, which contributes to the up-regulation of cardiac pathologic hypertrophy markers including atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), and leads to cardiac contractile dysfunction. Garlic oil treatment significantly inhibited the up-regulation in MAPK (e.g., p38, JNK and ERK1/2) and IL-6/MEK5/ERK5 signaling pathways in the diabetic rat hearts, reducing the levels of cardiac pathologic hypertrophy markers such as ANP and BNP, and improving the cardiac contractile function. Collectively, data from these studies demonstrate that garlic oil shows the potential cardioprotective effects for protecting heart from diabetic cardiomyopathy
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