1,618 research outputs found

    FIGURE 2 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

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    FASN protein expression in tumor glands is inversely correlated with FASN gene methylation in tumor tissue in primary prostate tumors. A, Representative plots of beta values (range: 0–1) by FASN probe on InfiniumEPIC for three tumors among the lowest (blue, H-score range from 3–4) and highest (red, H-score range from 289–292) mean FASN protein expression in the JHU cohort. Mean FASN beta values are negatively correlated with FASN protein levels by immunostaining for tumors in JHU cohort (B) and with FASN protein levels by RPPA in TCGA cohort (C). Each point in B and C represents an individual tumor.</p

    FIGURE 4 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

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    FASN protein expression, and to a lesser extent FASN gene methylation, is associated with ERG status in primary tumor cohort. A, FASN protein expression by immunostaining is higher in ERG+ compared with ERG− cases in the JHU primary tumor cohort; each point represents an individual tumor. B, FASN protein expression by immunostaining is also increased in ERG+ compared with ERG− cases from the PCBN cohort; each point represents an individual tumor. C,FASN probe methylation varies significantly by ERG status for several probes. D,FASN gene methylation mean beta value is not significantly different by ERG status in JHU cohort; each point represents an individual tumor. E,FASN gene expression is significantly higher in ERG fusion positive compared with ERG fusion negative tumors in the WCDT cohort; each point represents an individual tumor. F,FASN gene mean methylation is significantly lower in ERG fusion positive compared with ERG fusion negative tumors in the WCDT cohort; each point represents an individual tumor (*, P P P P < 0.0001).</p

    FIGURE 3 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

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    FASN protein expression in tumor glands is inversely correlated with FASN gene methylation in tumor tissue in metastatic CRPC cohort. A, Representative plots of CpG methylation level in FASN by WGBS with corresponding FASN mRNA expression (TPM) for three representative tumors with low (blue) and high (red) FASN gene expression in the SU2C WCDT cohort. Mean FASN CpG methylation level is negatively correlated with FASN mRNA expression in the SU2C WCDT samples; each point represents an individual tumor in B.</p

    Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study

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    Background: The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy.Methods: Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018-2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of >= 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site.Results: LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15-1.096, P = 0.003). The rate of >= 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56-0.85, P = 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41-0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56-0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60-0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52-0.94, P = 0.019) volume centres (vs. VERY HIGH).Conclusion: Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes

    FIGURE 6 from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

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    Neither FASN protein, nor FASN gene methylation are associated with self-identified race. A, FASN protein expression by race in JHU primary tumor cohort. B, FASN protein expression by race in PCBN primary tumor cohort. C, FASN protein expression by race in TCGA primary tumor cohort. D,FASN gene expression by race in TCGA primary tumor cohort. E,FASN gene methylation mean beta value by self-identified race in JHU primary tumor cohort. F,FASN gene methylation mean beta value by self-identified race in TCGA primary tumor cohort (*, P < 0.05).</p
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