187,512 research outputs found

    Evaluación de propiedades químicas y funcionales durante la fermentación alcohólica de mostos con distintas fuentes de carbohidratos

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    Se realizó el monitoreo de propiedades físico-químicas y funcionales en procesos de fermentación alcohólica de fructosa, miel de abejas y miel de abejas con 10% de sacarosa, mediante la medición del contenido de sólidos solubles, acidez titulable, pH y del contenido de fenoles totales y la actividad antioxidante por el ensayo de reducción de hierro - FRAP. Adicionalmente, se determinó el contenido de glucosa, fructosa, etanol y glicerol mediante HPLC durante el tiempo de fermentación. En las fermentaciones de miel y miel con adición de sacarosa se alcanzaron grados alcohólicos de 15% y no se encontraron diferencias significativas en los demás parámetros evaluados. Los ensayos con fructosa mostraron la inhibición de la levadura en el proceso fermentativo, además de contenidos de fenoles totales y de actividad antioxidante significativamente diferentes en comparación con los demás ensayos.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] ColcienciasUniversidad Nacional de Colombia1101-586-35750Desarrollo de un modelo productivo de bebidas fermentadas de miel como estrategia para generar valor en el ámbito característico de la apicultura en Colombian

    Monitoreo de la fermentación de agraz (Vaccinium Meridionale) y miel de Apis Mellifera mediante electroanálisis

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    Dentro de la realización del proyecto se planeó la realización de un seminario sobre calidad y generación de valor en productos apicolas, en el cual se mostraron los principales aspectos relacionados con calidad de materias primas y del producto y con el desarrollo del proceso y control. En la presente ponencia se muestran procesos de fermentación alcohólica de agraz y miel de abejas.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] ColcienciasUniversidad Nacional de Colombia1101-586-35750Desarrollo de un modelo productivo de bebidas fermentadas de miel como estrategia para generar valor en el ámbito característico de la apicultura en Colombian

    Effectiveness of the 3rd and successive lines of systemic treatment in patients with metastatic colorectal cancer

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    RESUMEN: Introducci√≥n. El regorafenib, el TAS-102 y la terapia anti-EGFR son las principales opciones terap√©uticas aprobadas para los pacientes con c√°ncer colorrectal metast√°sico (CCRm) que hayan progresado despu√©s de recibir dos l√≠neas de terapia sist√©mica. A pesar de ello, el beneficio cl√≠nico y el incremento de la supervivencia global obtenidos con estos tratamientos, seg√ļn los datos de los ensayos cl√≠nicos, son escasos, aproximadamente 4-6 meses. En este estudio se pretende valorar la eficacia y toxicidad de estos tratamientos en la pr√°ctica real con pacientes no seleccionados. M√©todos. Estudio retrospectivo que analiza pacientes con diagn√≥stico de CCRm tratados en el Hospital Universitario Marqu√©s de Valdecilla, que han recibido terapia en 3¬™ y/o sucesivas l√≠neas con los tratamientos aprobados en √©sta entre abril de 2011 y marzo de 2019.Resultados Un total de 46 pacientes han sido incluidos y analizados en este estudio. Los tratamientos evaluados en 3¬™l√≠nea fueron regorafenib (50%), terapia anti-EGFR (39,1%) y TAS-102 (10,9%). Los efectos adversos m√°s comunes fueron s√≠ndrome mano-pie (47,8%) y na√ļseas (39,1%) en los enfermos tratados con regorafenib, anemia (66,7%) y alteraciones hep√°ticas (44,4%) con terapia anti-EGFR y anemia (80%) y alteraciones hep√°ticas (60%) con TAS-102. Valorando la respuesta objetiva, un 8,7% de los enfermos tratados con regorafenib alcanzaron respuesta parcial (RP) y un 13% enfermedad estable (EE), en el caso de tratados con terapia anti-EGFR un 5,6% en ambos casos (RP/EE) y en los que recibieron TAS-102 un 20% alcanzaron cada una de las respuestas mencionadas (RP/EE). El resto de pacientes sufrieron progresi√≥n. La mediana de supervivencia libre de progresi√≥n (SLP) en la poblaci√≥n global fue de 4 meses (IC 95%: 2,6-5,4), en el subgrupo de regorafenib fue de 4 meses (IC 95%:2,5-6), en el de anti-EGFR 4 meses (IC 95%:0,9-5,1) y en el de TAS -102 3 meses (IC 95%:0,9-5,2). La mediana de supervivencia global (SG) para nuestra poblaci√≥n fue de 5 meses (IC 95%:1-5), 7 meses (IC 95%:3,3-10,7) en los pacientes con regorafenib, 3 meses con anti-EGFR (IC 95%:1-5,1) y 3 meses con TAS-102 (IC 95%:0,9-5,2). Conclusiones. Las caracter√≠sticas de los pacientes, las toxicidades documentadas y la eficacia de los tratamientos fueron similares y comparables con las observadas en los ensayos de referencia.ABSTRACT: Introduction Regorafenib, TAS-102 and anti-EGFR therapy are the main therapeutic options currently approved for patients with metastatic colorectal cancer (mCRC) in whom progression of the disease has occurred after receiving two lines of systemic therapy. In spite of this, the clinical benefit and the increase of the overall survival obtained with these treatments according to the data of the clinical trials are scarce, approximately 4-6 months. This study aims to assess the efficacy and toxicity of these treatments in current practice with non-selected patients. Methods. Retrospective study that analyzes patients diagnosed with mCRC in the HUMV who have received therapy in the 3rd and / or successive lines with the treatments approved on this between April 2011 and March 2019. Findings A total of 46 patients were included and analyzed in this study with the data obtained. The treatments evaluated in 3rd line were regorafenib (50%), anti-EGFR therapy (39.1%) and TAS-102 (10.9%). The most common adverse effects were hand-foot syndrome (47.8%) and nausea (39.1%) in patients treated with regorafenib, anemia (66.7%) and liver disorders (44.4%) with anti-EGFR therapy, and anemia (80%) and hepatic alterations (60%) with TAS-102. Assessing the objective response, 8.7% of patients treated with regorafenib achieved a partial response (PR) and 13.04% stable disease (SD), in the case of patients treated with anti-EGFR therapy 5.6% in both cases (PR/SD), and in those who received TAS- 102 20% reached each of the responses mentioned (PR/SD). The rest of the patients suffered progression. The median progression-free survival (PFS) for the overall population was 4 months (95% CI: 2.6-5.4), in the subgroup of regorafenib was 4 months (95% CI: 2.5- 6), in the case of anti-EGFR 4 months (95% CI: 0.9- 5.1) and in that of TAS -102 3 months (95% CI: 0.9-5.2). The mean overall survival (OS) in our population was 5 months (95% CI: 1.01-3.02), 7 months (95% CI: 3.3- 10.7) for patients with regorafenib, 3 months (95% CI: 1-5,1) with anti-EGFR and 3 months (95% CI: 0.9-5.2) with TAS-102. Interpretation. The characteristics of the patients, the toxicities documented and the efficacy of the treatments were similar and comparable with those previously reported in the pivotal clinical trials.Grado en Medicin

    The contribution of technological and non-technological innovation to environmental performance. An analysis with a complementary approach

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    In this study, we pursue two objectives. First, we analyse the influence of product, process, and non-technological innovation on environmental performance. Second, we explore the existence of complementarities or substitutabilities between the different combinations of these three types of innovations to learn which combinations improve or worsen environmental performance. The analyses were performed using data from the 2013 Technological Innovation Panel (PITEC) for Spanish manufacturing companies. We use the two-stage least-squares method as an instrumental variable estimator, which allows us to control the endogeneity and obtain consistent estimators. Our findings indicate that product innovation and process innovation have a negative influence on environmental performance. Likewise, we have also found that the simultaneous implementation of product innovation and process innovation is unconditionally substitutive and that the joint implementation of process innovation and non-technological innovation is conditionally substitutive. This result reinforces the position of those researchers who have pointed out that the association between a greater technology orientation and a better firm environmental performance is probably too simplistic. Finally, it should be emphasized that only non-technological innovation contributes to achieving better environmental performance and that the joint implementation of product innovation and non-technology innovation is conditionally complementary.Junta de Extremadura | Ref. GR1809

    Bromélias fibrosas utilizadas como fonte de matéria-prima por comunidades tradicionais da América Latina: uma revisão

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    Sustainable Design includes a holistic approach that takes into account the entire life cycle of a product or system, from its origin to disposal. This approach has parallels with the knowledge and practices developed by traditional communities in Latin America. The present research aimed to carry out a bibliographical review of studies that present and describe the use of leaf fibers from different species of bromeliads by traditional communities in Latin America, highlighting their potential in strengthening the environmental, economic and social pillars of sustainable design and sustainable crafts. From the analysis of 19 selected works, several traditional uses of 17 species of Bromeliaceae were identified, with Aechmea magdalenae, Bromelia hieronymi and Neoglaziovia variegata being the most cited species. The use of bromeliads by traditional communities in Latin America has great cultural and economic relevance, and an important example of cultural sustainability that must be preserved.O Design Sustent√°vel inclui uma abordagem hol√≠stica que leva em considera√ß√£o todo o ciclo de vida de um produto ou sistema, desde a sua origem at√© o descarte. Tal abordagem possui paralelos com os saberes e pr√°ticas desenvolvidas por comunidades tradicionais da Am√©rica Latina. Entre as fam√≠lias bot√Ęnicas utilizadas para tais fins, Brom√©lias tem sido amplamente descrita em diferentes locais. A presente pesquisa teve como objetivo realizar uma revis√£o bibliogr√°fica explorat√≥ria de estudos que apresentam e descrevem o uso de fibras foliares de diferentes esp√©cies de brom√©lias por comunidades tradicionais da Am√©rica Latina. A partir da an√°lise de 19 trabalhos selecionados, foram identificados diversos usos tradicionais de 17 esp√©cies de Brom√©lias, sendo Aechmea magdalenae, Bromelia hieronymi e Neoglaziovia variegata as esp√©cies mais citadas. O uso de brom√©lias por comunidades tradicionais na Am√©rica Latina apresenta grande relev√Ęncia cultural e econ√īmica, e um importante exemplo de sustentabilidade cultural que deve ser preservada

    Extracting the speed of sound in the strongly interacting matter created in ultrarelativistic lead-lead collisions at the LHC

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    International audienceUltrarelativistic nuclear collisions create a strongly interacting state of hot and dense quark-gluon matter that exhibits a remarkable collective flow behavior with minimal viscous dissipation. To gain deeper insights into its intrinsic nature and fundamental degrees of freedom, we extracted the speed of sound in this medium created using lead-lead (PbPb) collisions at a center-of-mass energy per nucleon pair of 5.02 TeV. The data were recorded by the CMS experiment at the CERN LHC and correspond to an integrated luminosity of 0.607 nb‚ąí1^{-1}. The measurement is performed by studying the multiplicity dependence of the average transverse momentum of charged particles emitted in head-on PbPb collisions. Our findings reveal that the speed of sound in this matter is nearly half the speed of light, with a squared value of 0.241 ¬Ī\pm 0.002 (stat) ¬Ī\pm 0.016 (syst) in natural units. The effective medium temperature, estimated using the mean transverse momentum, is 219 ¬Ī\pm 8 (syst) MeV. The measured squared speed of sound at this temperature aligns precisely with predictions from lattice quantum chromodynamic (QCD) calculations. This result provides a stringent constraint on the equation of state of the created medium and direct evidence for a deconfined QCD phase being attained in relativistic nuclear collisions

    REENACT: A step forward in immersive learning about Human History by augmented reality, role playing and social networking

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    Classical pedagogy about Human History has dealt with many historic events as a mere collection of dates, locations and a number of confronted sides with a final result of victory or defeat. In the same line of thinking, many popular battles and wars are not well understood due to non-rigorous treatment in comics, movies and documentaries. In order to fight these drawbacks we propose a novel technology-enhanced pedagogical approach named REENACT which is aimed at engaging groups of people into immersive experiences to improve their learning about historical battles and wars from the points of view of reenactors and historians. To this aim, REENACT relies on handheld devices and an advanced technological facility that comprises social networking features, augmented reality capabilities and repositories of multimedia contents. Our pedagogical approach has been experimentally validated in collaboration with the Foundation of the Hellenic World in Greece and the School of Telecommunication Engineering from the University of Vigo in Spain. The obtained results in terms of Quality of Experience, Quality of Service and Quality of Community reveal the potential value of the approach to provide new edutainment collective experiences which remain unexplored thus far in educational environments

    Supplementary methods.

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    Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls. Multilayer networks were constructed using mutual information for topological analysis, and Boolean simulations were constructed using Pearson correlation to identified paths within and among all layers. The path more commonly found from the Boolean simulations connects protein MK03, with total T cells, the thickness of the retinal nerve fiber layer (RNFL), and the walking speed. This path contains nodes involved in protein phosphorylation, glial cell differentiation, and regulation of stress-activated MAPK cascade, among others. Specific paths identified were subsequently analyzed by flow cytometry at the single-cell level. Combinations of several proteins (GSK3AB, HSBP1 or RS6) and immune cells (Th17, Th1 non-classic, CD8, CD8 Treg, CD56 neg, and B memory) were part of the paths explaining the clinical phenotype. The advantage of the path identified from the Boolean simulations is that it connects information about these known biological pathways with the layers at higher scales (retina damage and disability). Overall, the identified paths provide a means to connect the molecular aspects of MS with the overall phenotype.</div

    Path analysis in MS patients.

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    Representations of the multi-layer paths identified from the Boolean simulations when the input started at the genomics layer. The top paths (those that passed the test for negative controls) are shown for each input (gene, protein, or cell)-output (clinical phenotype) pair. The nodes for each layer are color-coded to represent the degree of a given node, i.e., the number of times the node appears in a path, as a percentage of the total number of paths. High resolution paths are available at https://keithtopher.github.io/fivelayer_pathways/.</p

    Linear regression models between phosphoproteins, cell subtypes and clinical phenotype.

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    Linear regression analysis relating the percentage of immune cell subtypes expressing phosphorylated GSK3AB, HSBP1 or RS6 with the phenotype. The heatmap shows the adjusted R2 of the significant models. EDSS: Expanded Disability Status Scale; GMSSS: Global Multiple Sclerosis Severity Score; T25WT: timed 25 feet walking test; 9HPT: nine- hole peg test; LCVA: low contrast (2.5%) visual acuity; HCVA: high contrast visual acuity; RNFL: retinal nerve fiber layer (m: macular; tp: temporal peripapillary); INL: inner nuclear layer; T2LV: T2 lesion volume; ORL: outer retinal layer; NBV: normalized brain volume; NWMV: normalized white matter volume; NGMV: normalized gray matter volume.</p
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