39 research outputs found

    Paraneoplastic syndrome (usefulness of 18FDG-PET)

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    LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

    Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents

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    International audienceMixing double-hydrophilic block copolymers containing a poly(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies

    Multifunctional nanoparticles : from the detection of biomolecules to the therapy

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    International audienceThe intense research activities devoted to nanotechnology led to the development of a wide variety Of Multifunctional nanoparticles. Besides their small size which opens the route to the exploration of living matter at the subcellular scale. the properties of these particles can be accurately tuned by varying the composition, the size, the shape and the chemical composition Of the surface. Some of these particles are peculiarly suited for biological and biomedical applications. This review provides an overview on the sensing and biomedical applications of Multifunctional gold and gadolinium oxide nanoparticles which were developed by a network of sonic laboratories of Rhone-Alpes Region

    A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

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    International audienceThe functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary elimination