735 research outputs found

    E-skin – Based advanced wearable technology for Health Management

    No full text
    The natural barrier that separates us from our surroundings is our skin. It enables us to experience a range of forms of sensations, temperature variations, and different levels of touch pressure. Because human skin is so instinctive, it's simple to overlook the intricacy of the body's primary sensory organ. Our skin contains a variety of diverse, highly specialized sense receptors that enable it to perceive functions from our surroundings efficiently and securely with great precision. These receptors, by making use of an integrated flexible system, convert physical contact information into electrical impulses before sending it to the nervous system for further involved interpretation. Electronic skin, i.e., E-skin also referred to as e-skin or synthetic skin, is a very thin electrical material made by fusing electronic components to elastic, pliable substrates that are made with efforts of mimicking the potentials of human skin. E-skin is a cutting-edge technology that is largely used for medicinal purposes, such as detecting and perceiving internal life sign processes in living beings, as well as their unprecedented monitoring. To explore the aspects of E-skin for health wellness, this article explores recent advancements in different E-skin technologies, properties of the materials used in e-skin fabrication, and its future potential

    Streaming through a case of SREAT

    No full text
    Abstract Background Hashimoto’s encephalopathy, also known as steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is an autoimmune neuroendocrine disorder marked by impaired brain function. It is a diagnosis of exclusion with variable nature of presentation and no gold standard investigation of choice. Case presentation Here, we report a case of SREAT in a 26-year-old female who presented to our Emergency Department with altered sensorium and generalised tonic clonic seizures. After thorough clinical examination and initial resuscitation, a provisional diagnosis of neuroglycopenic injury or possible encephalitis was made. Broad-spectrum antibiotics were initiated. Routine investigations and cerebrospinal fluid (CSF) study were inconclusive except for neutrophilic leucocytosis. Magnetic resonance imaging (MRI) depicted hyper-intense signal changes around bilateral hippocampus and thalamus. Serum anti-thyroid peroxidase (anti-TPO) was strongly positive while other serum and CSF autoantibodies were within normal limits. A diagnosis of SREAT was made and she responded brilliantly to systemic corticosteroids. Incidentally, anti-SSA (anti-Ro) and anti-SSB (anti-La) were positive and a possible association between Sjogren’s syndrome and SREAT was insinuated. Conclusion There is a long list of differentials for SREAT and a proper diagnostic criteria must be followed to reach at a conclusion. It can be easily missed and remain underreported due to its overlapping nature and ambiguous presentation. Hence, clinicians must have high index of suspicion for the disease and optimal therapy should be initiated early to improve the long term mortality

    Progression in Quantum Sensing/Bio-Sensing Technologies for Healthcare

    No full text
    The 5th/6th generation bio-sensing technology is an emerging field which connects smart technologies like Artificial Intelligence, Internet of Things and Machine Learning with efficient micro/nano-enabled sensing platform for making point-of-care (POC) devices to investigate health management strategies. Recently, the integration and interfacing between quantum measurement, signaling, and optimized bio-actives has led to investigate the minute biological events with anomalous sensitivity. Such technologies are expected to provide the possibility to measure and record changes at quantum scales with varying pressure, temperature, and electromagnetic fields. Considering current scenarios, this perspective critically highlights state-of-art quantum sensing technology along with their challenges and prospects

    Deficient Phagocytosis in Circulating Monocytes from Patients with COVID-19-Associated Mucormycosis

    No full text
    ABSTRACT Cases of rhino-orbital mucormycosis in patients suffering from severe coronavirus disease 2019 (COVID-19) were reported in different parts of the world, especially in India. However, specific immune mechanisms that are linked to susceptibility to COVID-19-associated mucormycosis (CAM) remain largely unexplored. We aimed to explore whether the differential regulation of circulating cytokines in CAM patients had any potential pathogenic links with myeloid phagocyte function and susceptibility to mucormycosis. A small cohort of Indian patients suffering from CAM (N = 9) as well as COVID-19 patients with no evidence of mucormycosis (N = 5) were recruited in the study. Venous blood was collected from the patients as well as from healthy volunteers (N = 8). Peripheral blood mononuclear cells and plasma were isolated. Plasma samples were used to measure a panel of 48 cytokines. CD14+ monocytes were isolated and used for a flow cytometric phagocytosis assay as well as a global transcriptome analysis via RNA-sequencing. A multiplex cytokine analysis of the plasma samples revealed reduction in a subset of cytokines in CAM patients, which is known to potentiate the activation, migration, or phagocytic activity of myeloid cells, compared to the COVID-19 patients who did not contract mucormycosis. Compared to monocytes from healthy individuals, peripheral blood CD14+ monocytes from CAM patients were significantly deficient in phagocytic function. The monocyte transcriptome also revealed that pathways related to endocytic pathways, phagosome maturation, and the cytoskeletal regulation of phagocytosis were significantly downregulated in CAM patients. Thus, the study reports a significant deficiency in the phagocytic activity of monocytes, which is a critical effector mechanism for the antifungal host defense, in patients with CAM. This result is in concordance with results regarding the specific cytokine signature and monocyte transcriptome. IMPORTANCE A number of cases of mucormycosis, often fatal, were reported among severe COVID-19 patients from India as well as from some other parts of the world. However, specific immunocellular mechanisms that underlie susceptibility to this fungal infection in COVID-19 remain largely unexplored. Our study reports a deficiency in phagocytosis by monocytes in COVID-19 patients who are concomitantly afflicted with mucormycosis, with this deficiency being linked to a characteristic monocyte transcriptome as well as a circulating cytokine signature. The functional phenotype and cytokine signature of the monocytes may provide useful biomarkers for detecting potential susceptibility to mucormycosis in COVID-19 as well as in other viral infections

    A Multi-centre Study to Evaluate the Long-Term Efficacy and Safety of Biosimilar Infliximab (Infimab™) in Ankylosing Spondylitis in Real-world Clinical Settings - A perspective from Eastern India

    Get PDF
    Introduction: Owing to dearth of data on infliximab biosimilars in Indian patients, a pan-India case database-based study with infliximab biosimilar BOW015 (Infimab™) was carried out to capture its efficacy and safety in real world clinical settings in India. Here, we assessed its efficacy and safety in ankylosing spondylitis (AS) among patients in the East India cohort. Materials and methods: Data were collected from multiple centers across the eastern region of India. Patients diagnosed with AS, within the preceding 4-6 months during the preceding one year were included in the study. Patients who were given BOW015 for other indications, prior innovator infliximab or other biologics were excluded from the study. Primary variable was Ankylosing Spondylitis Disease Activity Scale (ASDAS) response defined as change of > 2 in the ASDAS score from the baseline by 4-6 months of follow up. Results: The cohort consisted of 149 patients, predominantly male (69.8%), with mean (±SD) age of 36.75 (±11.11) years and mean (±SD) body weight of 58.26 (±15.4) kgs. Of the treated patients, 91 (61.1%) patients were administered four doses, 10 (6.7%) patients were administered three doses, 37 (24.8%) patients were administered two doses and 11 (7.4%) patients were administered only a single dose of BOW015. In the final analysis set, 81 patients had data at baseline and 4th visit. Among the 81 patients, 74 (91%) patients achieved major improvement, 5 (6%) patients achieved clinically important improvement and 2 (3%) were non-responders at 4th visit. Secondarily, cross categorization of the cohort into disease activity categories by number of infusions administered from baseline to 4th visit and assessment of trends in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also carried out and these too confirmed the efficacy of BOW015. Conclusion: Infimab™ (BOW015) showed significant improvement in ASDAS and BASDAI in patients with AS at the end of 4-6 months of follow up with its clinical benefits being apparent as early as first dose of BOW015

    Prelude to political economy : a study of the social and political foundations of economics

    No full text
    xv, 288 p. : ill. ; 24 cm

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Get PDF

    Polypyrrole and associated hybrid nanocomposites as chemiresistive gas sensors: A comprehensive review

    No full text
    The detection of toxic and flammable gases entwines a wide diversity of application purposes, such as medical diagnosis, food quality monitoring, environmental tracking, and so forth. In recent, polypyrrole (PPy) nanostructure and its hybrid composite have been emerged as an auspicious gas sensing element because of their unique physicochemical attributes. This review article demonstrates a comprehensive outlook of rapid progress in polypyrrole (PPy) and associated hybrid composite based chemiresistive gas sensors till now. Furthermore, the role of PPy nanostructures and organic or inorganic additives (CNT, graphene or its derivative, metal nanoparticle, metal oxides, metal sulfides) in PPy matrix towards improved gas sensing performance are discussed hereunder. The detailed and systematic discussion on the synthesis strategies, gas sensing principle of the PPy nanostructures, and its composites along with the development of sensor device configuration provide an in-depth understanding of the aforesaid topic to the readers. However, some relevant limitations of PPy and associated composites based gas sensor are addressed after investigating the thorough literature survey. Finally, this article will promote an advanced as well as focused direction to the readers for further development of PPy based high-performance gas sensing devices

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)