85 research outputs found

    Total synthesis of the marine natural products lukianols A and B

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    Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved using N-benzenesulfonyl-3,4-dibromopyrrole (3) as a common starting material. The key synthetic strategy developed is the combined bromine-directed lithiation and palladium-catalyzed cross-coupling of 3 to produce 3,4-diarylpyrrol-2-carboxylates. Regioselective iodination of the phenolic intermediate 24 was thoroughly investigated for the synthesis of lukianol B

    ロウシャ ニ ナルコト ト ロウキョウシ ニ ナルコト アル ロウキョウシ ノ アイデンティティ ト ビリーフ ノ ヘンヨウ

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    ろう教育にはろう児の聴覚障害のみに焦点をあてる口話教育のアプローチと、バイリンガル教育としてのろう教育の2つの異なるアプローチがある。この2つのアプローチの違いはろう教育における手話の有効性の議論にとどまらず、ろう者のアイデンティティやろう教育実践に関わる教員のビリーフの点からも重要な意味を持つ。本研究は口話教育で育ったろう者の教員が自ら聾学校の教員となって、口話教育とバイリンガルろう教育両方の教育実践を経験する中で、どのようにろう者としてのアイデンティティを確立・変容させ、同時に教育、言語、そして言語教育についてのビリーフを変容させたかについての記録である。当事者による学術的報告を可能にする対話的自己エスノグラフィーの手法の使用をめぐる方法論的な考察とともに、聴の家庭でろう児として育つこと、ろう者であること、ろう教育の実践者であること、の3つがどのように変容したかについて分析した。There are two different approaches to Deaf education: the aural-oral approach, which focuses only on the hearing impairment of Deaf children, and the bilingual approach to Deaf education. The difference between these two approaches is important not only for the discussion of the effectiveness of sign language in Deaf education but also for the identity of Deaf people and the beliefs of teachers involved in Deaf education practice. This study documents how a Deaf teacher who grew up in an aural-oral approach and later served as a teacher at two deaf schools; one in aural-oral approach and the other in bilingual approach, established and transformed her identity as a Deaf person and at the same time transformed her beliefs about education, language, and language teaching. Along with methodological considerations surrounding the use of dialogic autoethnography that allows for scholarly reporting by minorities themselves, the present study analyses how three things have interacted with each other in their transformation: growing up as a Deaf child in a hearing family, being Deaf, and being a practitioner of Deaf education.研究論文Research Paper

    Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia

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    ゲノム解析から急性赤白血病の変異プロファイルと治療標的を解明 --特定の遺伝子変異群の組み合わせと、特徴となる遺伝子の増幅が鍵--. 京都大学プレスリリース. 2022-08-05.Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by prominent erythroid proliferation whose molecular basis is poorly understood. To elucidate the underlying mechanism of erythroid proliferation, we analyzed 121 AEL using whole-genome/exome and/or targeted-capture sequencing, together with transcriptome analysis of 21 AEL samples. Combining publicly available sequencing data, we found a high frequency of gains/amplifications involving EPOR/JAK2 in TP53-mutated cases, particularly those having >80% erythroblasts designated as pure erythroid leukemia (10/13). These cases were frequently accompanied by gains/amplifications of ERG/ETS2 and associated with a very poor prognosis, even compared with other TP53-mutated AEL. In addition to activation of the STAT5 pathway, a common feature across all AEL cases, these AEL cases exhibited enhanced cell proliferation and heme metabolism and often showed high sensitivity to ruxolitinib in vitro and in xenograft models, highlighting a potential role of JAK2 inhibition in therapeutics of AEL

    Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

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    A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

    Measurements of top-quark pair differential cross-sections in the eμe\mu channel in pppp collisions at s=13\sqrt{s} = 13 TeV using the ATLAS detector