2,644 research outputs found

    The Design and Technology Development of the JUNO Central Detector

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    International audienceThe Jiangmen Underground Neutrino Observatory (JUNO) is a large scale neutrino experiment with multiple physics goals including deter mining the neutrino mass hierarchy, the accurate measurement of neutrino oscillation parameters, the neutrino detection from the super nova, the Sun, and the Earth, etc. JUNO puts forward physically and technologically stringent requirements for its central detector (CD), including a large volume and target mass (20 kt liquid scintillator, LS), a high energy resolution (3% at 1 MeV), a high light transmittance, the largest possible photomultiplier (PMT) coverage, the lowest possible radioactive background, etc. The CD design, using a spherical acrylic vessel with a diameter of 35.4 m to contain the LS and a stainless steel structure to support the acrylic vessel and PMTs, was chosen and optimized. The acrylic vessel and the stainless steel structure will be immersed in pure water to shield the radioactive back ground and bear great buoyancy. The challenging requirements of the acrylic sphere have been achieved, such as a low intrinsic radioactivity and high transmittance of the manufactured acrylic panels, the tensile and compressive acrylic node design with embedded stainless steel pad, one-time polymerization for multiple bonding lines. Moreover, several technical challenges of the stainless steel structure have been solved: the production of low radioactivity stainless steel material, the deformation and precision control during production and assembly, the usage of high strength stainless steel rivet bolt and of high friction efficient linkage plate. Finally, the design of the ancillary equipment like the LS filling, overflowing and circulating system was done

    PROJETO CURUMIM E HESITAÇÃO VACINAL COM VACINAS CONTRA COVID-19 EM UMA COORTE DE CRIANÇAS E ADOLESCENTES

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    Introdução/Objetivo: O Projeto Curumim é um estudo de não inferioridade, sobre eficácia, imunogenicidade e segurança da vacina inativada (Coronavac) contra SARS-CoV-2, em crianças e adolescentes de 3 a 17 anos, comparado a vacina BNT162b2 (Pfizer), com um braço randomizado e um braço aberto (sem cegamento, administrando Coronavac). O braço aberto surgiu da demanda de pais que, desconfortáveis em vacinar as crianças com a Pfizer, optaram pela Coronavac, plataforma vacinal com vírus inativado, mais conhecida. O objetivo deste trabalho é divulgar a hesitação vacinal que ocorreu entre familiares de uma coorte de crianças e adolescentes, com a vacina contra COVID-19. Métodos: Os participantes (5-17 anos) do braço randomizado foram divididos em dois grupos (2:1) e receberam vacina Coronavac/Butantan ou BNT162b2 (Pfizer). Os participantes do braço aberto receberam apenas a Coronavac. Foram aplicadas 2 doses dos imunizantes, com intervalo de 28 dias. Este estudo está registrado no ClinicalTrials.gov NCT05225285. Resultados: Foram incluídos 1125 participantes de 3 a 17 anos. Destes, 460 maiores de 5 anos de idade, elegíveis para a randomização, entretanto, 119 (25%) optaram pelo braço aberto, para receber a vacina Coronavac, por uma recusa dos familiares a vacina BNT162B2 (Pfizer). Hesitação vacinal é o atraso ou recusa em aceitar as vacinas recomendadas, quando elas estão disponíveis nos serviços de saúde. O Programa Nacional de Imunização (PNI) do Brasil é um modelo exitoso por fornecer ampla quantidade de vacinas forma gratuita a população, mas desde 2016 vem enfrentando quedas nas suas coberturas. A divulgação de notícias falsas sobre as vacinas contra COVID-19 causou uma desconfiança na população, especialmente referente às novas plataformas de imunização, como as vacinas de RNAm. Esse fenômeno causou uma quebra da confiança da população, causando inclusive queda nas taxas de vacinação de outras doenças imunopreviníveis. A cobertura vacinal contra COVID-19 em crianças no Brasil ainda é baixa e movimentos contrários a falsas notícias sobre vacinas são necessários, para melhor adesão à vacinação. Conclusão: Nesta coorte, houve uma recusa em receber a vacina da Pfizer em 25% das famílias dos participantes maiores de 5 anos de idade. É de extrema importância conhecer o fenômeno de hesitação vacinal, para que sociedades médicas, pesquisadores e gestores se mobilizem em busca de maiores coberturas vacinais contra COVID-19 e outras doenças imunopreviníveis

    Uso de extrato etanólico de própolis no controle alternativo de Machophomina phaseolina em sementes de feijão-caupi.

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    Este estudo foi motivado a partir de diversos trabalhos que demonstram a ação antimicrobiana do EEP das abelhas Apis mellifera

    [In Press] Assessment of the left atrial volume and function following percutaneous mitral balloon valvuloplasty : insights into acute and late impact of atrial fibrillation on atrial remodeling

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    Background: Rheumatic mitral stenosis (MS) leads to LA remodeling with disordered electrical activation that may revert with valve intervention. This study aimed to assess the acute and late impact of percutaneous mitral balloon valvuloplasty (PMBV) on LA volume and function in patients with atrial fibrillation (AF) compared with sinus rhythm. Methods: A total of 167 patients with severe MS undergoing PMBV were prospectively enrolled. LA volumes and function were measured by three-dimensional echocardiography (3DE) pre PMBV, within 24 to 48 h after PMBV, and at 1 year. Results: Mean age was 43.5 ± 11.8 years old, and 142 (85%) patients were women. At baseline, 46 patients (27.5%) were in permanent AF, and 62 (37.1%) classified as New York Heart Association functional class III or IV. In sinus rhythm population, LA volumes decreased immediately after PMBV and continue to decrease at 1-year follow-up. LA emptying fraction increased from 23.6 ± 10.4% to 33.8 ± 11.9% acutely after the procedure (p < 0.001), and to 37.2 ± 13.2% at 1-year follow-up (p = 0.028). Patients with AF only had a significant decrease in LA minimum volume immediately after PMBV, with no significant changes in maximum volume either immediately or at follow-up. In these patients, LA emptying fraction increased immediately after the procedure from 15.8 ± 9.9% to 22.8 ± 9.8 (p = 0.001) with no evidence for additional improvement at the 1-year follow-up. Age, and post-procedural mean gradient were identified as the most significant factors associated with the absolute changes in LA function between baseline and the 1-year follow-up. Conclusions: In patients with severe MS, the impact of PMBV on LA volume and function varies according to cardiac rhythm. In patients in sinus rhythm, the procedure leads to improvement of LA volumes and function both acutely and at 1-year follow-up. Patients with AF had a lesser improvement in LA function immediately after the procedure, without further improvement over time despite adequate relief of valve obstruction

    Prevalence and associated factors of mental health disorders among Brazilian healthcare workers in times of the COVID-19 pandemic: A web-based cross-sectional study.

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    The COVID-19 pandemic in Brazil affected mental health among healthcare workers. To objective of this study was to evaluate the mental health of healthcare workers in in the central-west region of the Brazil, estimating the prevalence of mental health disorders, and investigating associated factors, perceptions of safety, and self-perceptions about mental health in times of the COVID-19 pandemic. The questionnaire was divided into two parts that included general information and perceptions about the work process and identified symptoms using the Depression Anxiety Stress Scale-21 (DASS-21), and multiple linear regression analysis was conducted. A total of 1,522 healthcare workers participated in the survey. Overall prevalence of symptoms was calculated for depression (58.7%), anxiety (59.7%), and stress (61.7%). Physicians had 3.75 times greater risk of depression (1.59-8.85, 95% CI). Independent variables associated with depression symptoms were not feeling safe with the way services were organized (1.12:1.03-1.21, 95% CI) and self-perception of poor mental health (8.06: 4.03-16.10% CI). Working in management was protective, and married professionals had 12% lower risk of exhibiting symptoms of depression (0.79-0.99, 95% CI). Participants with self-perception of poor mental health had 4.63 greater risk for symptoms of anxiety (2.58-8.31, 95% CI). Protective factors were not having sought support for mental health (0.90: 0.82-0.99, 95% CI), having a graduate degree (0.71: 0.54-0.94, 95% CI), and not having been diagnosed with COVID-19 (0.90: 0.83-0.98, 95% CI). Perception of poor mental health was associated with 6.95-fold greater chance of developing stress symptoms. Protective factors from stress were having a degree in dentistry (0.81: 0.68-0.97, 95% CI), residing in Mato Grosso do Sul (0.91: 0.85-0.98, 95% CI), and not having sought mental health support services (0.88: 0.82-0.95, 95% CI). The prevalence of mental health disorders is high among healthcare workers, and is associated with professional category, organization of services provided, and self-perception of poor mental health, reinforcing the need for preventative measures

    A morfologia vegetal na perspectiva dos livros didáticos do ensino médio

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    Plant morphology is essential in determining the flora, and can contribute to the understanding of environmental issues and to the formation of students able to act consciously and sustainably. However, the traditional and decontextualized approach to Botany has resulted in the students' lack of interest. The purpose of this article was to analyze the content of plant morphology in Biology textbooks approved in the PNLD 2018. Documentary research, with a qualitative approach, was carried out, which revealed the little relevance given to the theme, the lack of reflective images and the low frequency of proposals for practical or group activities in most of the textbooks analyzed. We confirm the relevance of a careful analysis of textbooks, aiming at improve this important pedagogical tool that, many times, is the only didactic resource available, being decisive in the selection and in the way in which the contents will be developed in the classroom.La morfología vegetal es esencial en la determinación de la flora, y puede contribuir para comprensión de los problemas ambientales y para formación de estudiantes capaces de actuar de manera consciente y sostenible. Sin embargo, el enfoque tradicional y descontextualizado de la Botánica ha provocado el desinterés de los alumnos. Este artículo analizó el contenido de morfología vegetal en libros de texto (LT) de Biología aprobados en el PNLD 2018. Se realizó una investigación documental, con enfoque cualitativo, que reveló la poca relevancia dada al tema, la falta de imágenes reflexivas y la baja frecuencia de actividades prácticas o grupales en la mayoría de los libros. Ratificamos la pertinencia de un análisis cuidadoso de los LT, con objetivo de perfeccionar esta herramienta pedagógica que, muchas veces, es el único recurso didáctico disponible, siendo determinante en la selección y en la forma en que se desarrollarán los contenidos en el aula.A morfologia vegetal é essencial na determinação da flora, podendo contribuir para o entendimento de questões ambientais e para a formação de estudantes capazes de agir de modo consciente e sustentável. No entanto, a abordagem tradicional e descontextualizada da Botânica, tem culminado no desinteresse dos alunos. O intuito deste artigo foi analisar o enfoque dado à morfologia vegetal nos livros didáticos (LD) de Biologia aprovados no PNLD 2018. Foi realizada uma pesquisa documental, de abordagem qualitativa, que revelou a pouca relevância dada ao tema, a falta de imagens reflexivas e a baixa frequência de propostas de atividades práticas ou em grupo na maioria dos LD analisados. Ratificamos a relevância de uma análise criteriosa dos LD, visando ao aprimoramento dessa importante ferramenta pedagógica que, muitas vezes, é o único recurso didático disponível, sendo determinante na seleção e no modo como os conteúdos serão desenvolvidos em sala de aula

    Smartphone-based evaluation of static balance and mobility in long-lasting COVID-19 patients

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    BackgroundSARS-CoV-2 infection can lead to a variety of persistent sequelae, collectively known as long COVID-19. Deficits in postural balance have been reported in patients several months after COVID-19 infection. The purpose of this study was to evaluate the static balance and balance of individuals with long COVID-19 using inertial sensors in smartphones.MethodsA total of 73 participants were included in this study, of which 41 had long COVID-19 and 32 served as controls. All participants in the long COVID-19 group reported physical complaints for at least 7 months after SARS-CoV-2 infection. Participants were evaluated using a built-in inertial sensor of a smartphone attached to the low back, which recorded inertial signals during a static balance and mobility task (timed up and go test). The parameters of static balance and mobility obtained from both groups were compared.ResultsThe groups were matched for age and BMI. Of the 41 participants in the long COVID-19 group, 22 reported balance impairment and 33 had impaired balance in the Sharpened Romberg test. Static balance assessment revealed that the long COVID-19 group had greater postural instability with both eyes open and closed than the control group. In the TUG test, the long COVID-19 group showed greater acceleration during the sit-to-stand transition compared to the control group.ConclusionThe smartphone was feasible to identify losses in the balance motor control and mobility of patients with long-lasting symptomatic COVID-19 even after several months or years. Attention to the balance impairment experienced by these patients could help prevent falls and improve their quality of life, and the use of the smartphone can expand this monitoring for a broader population

    Análise do microcrédito no fomento de pequenos negócios

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    Esta pesquisa analisou a influência do microcrédito no desenvolvimento de pequenos negócios. Sob a ótica teórica, argumentou-se a importância do crédito para o desenvolvimento de negócios, fundamentado na Teoria do Desenvolvimento Econômico de Schumpeter e na Teoria do Desenvolvimento como Liberdade de Amartya Sem. Metodologicamente, realizou-se uma pesquisa qualitativa por meio de entrevistas, com 12 empreendedores que tomaram o microcrédito há mais de 12 meses, estabelecidos no município de Belém – PA. Homens e mulheres em igual condição, obtiveram crescimento de renda e geração de trabalho, para si, seus familiares e também para pessoas que vivem na comunidade, conseguindo atingir melhores condições de qualidade de vida, ampliando sua independência financeira e realizações pessoais. A avaliação do repagamento aos bancos indicou que empreendedores que utilizaram adequadamente os recursos em seus empreendimentos conseguiram atingir melhores resultados e cumprir com suas responsabilidades junto aos bancos. Dessa forma, esta pesquisa corroborou, na realidade local, pesquisas anteriores que observaram o microcrédito como um elemento importante para o crescimento de pequenos negócios

    Dilemas e possibilidades do lazer e da educação no Centro de Ciências da Universidade Federal de Juiz de Fora (UFJF)

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    The Centro de Ciências da Universidade Federal Juiz de Fora has a structure that aims to disseminate science serving the general public free of charge, with exhibition spaces that mix aspects of playfulness and education with the dissemination of science. The leisure present in the location dialogues with other fields, in addition to work and education, such as politics, economics, language, health, art, science and nature. Thus, leisure is a human need, and may have a critical and even 1 transformative connotation for the individual. According to Delors (2018), it is preferable to identify leisure activities as integrative actions of the pillars that form knowledge. Therefore, this work includes discussing how leisure is present along with the educational actions of the Centro de Ciências da UFJF under the bias of training of mediators by the university.O Centro de Ciências da Universidade Federal de Juiz de Fora possui uma estrutura que visa divulgar a ciência, atendendo o público geral de forma gratuita, com espaços de exposições que mesclam aspectos da ludicidade, da educação e da difusão da ciência. O lazer presente no espaço dialoga com outras práticas sociais, além do trabalho e da educação, tais como a política, a economia, a linguagem, a saúde, a arte e a ciência, podendo ter uma conotação crítica e, até mesmo, transformadora junto ao indivíduo. Posto isso, este trabalho visa discutir de que maneiras o lazer se faz presente junto às ações educativas do Centro de Ciências da UFJF sob o viés de formação dos mediadores pela universidade. O trabalho, de natureza qualitativa e exploratória, se pautou numa revisão bibliográfica, uma entrevista semiestruturada com o gestor do espaço e os questionários para os mediadores. A justificativa deste trabalho se pauta em um viés crítico sobre como o lazer é tratado como um fator separado à educação, além da minha experiência no Centro de Ciências como bolsista. Em linhas gerais, se percebe que o lazer atua como recurso didático pedagógico que agrega significados à educação, embora, nem sempre haja uma valorização, reconhecimento e treinamento para a presença deste fenômeno sociocultural
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